researchblog

[quadfather]

Originally Posted by kivi66

OK, Jim, just as clear as I can: induce, please, as a closest mediator, Dr.Wise derived impulse as a triggered reaction to the irritant at level #113. Just for our mutual satisfaction.

kivi,

What is your native language? Perhaps use that, so others can translate on your behalf.

[Wise Young]

Kivi66, my responses are in red. Wise.

Originally Posted by kivi66

Dr.Wise, I would like to know whether what is "IF" for Dr.Silver, for you rather "WHEN". Some credible data would be appreciated.

Why are you putting words into my mouth and then trying to pit what Dr. Silver said against what you think that I said? Like Dr. Silver, I believe that neuronal replacement is necessary for restoring function in people with lumbosacral spinal cord injury. I believe that it is possible and we are trying to gather the evidence for such therapies to initiate clinical trials in 2014.

Dr.Wise, I think this dramatization of events is superfluous and just does not correspond to reality.
You are wrong. There are many therapeutic nihilists. Many are critical of our clinical trials and oppose our taking therapies to trial for people with chronic spinal cord injury. I have been accused on giving false hope to people because we are testing therapies for chronic spinal cord injury. Therapeutic nihilists are convinced that nothing will work for chronic spinal cord injury. Such conviction is clear when doctors (or non-doctors) tell patients that they will never walk. It shows when they choose to test therapies only for acute spinal cord injury and not for chronic spinal cord injury. Many members of our community have given up hope that there will ever be therapies for them. It is an easy step to go from hopelessness to denial.

You seem to trying to pit Jerry Silver and me against each other. What is the purpose? It sounds as if you don't believe that the therapies we are testing or hoping to test will help spinal cord injury. If so, why don't you say so, instead of hiding behind Jerry Silver's opinion. I would be glad to do my best to explain why I am hopeful that the therapies we have chosen to study would work. Are you saying that transplantation of immunocompatible neural stem cells and axonal growth inhibitor blocker Cethrin will not work or are you trying to say that no therapy will ever work? The latter is what a therapeutic nihilist would say.

Finally, you are asking for evidence, knowing that this is what we are trying to gather. It is obvious that we don't have the cure yet and obviously the evidence is still being collected. I have said this many times. So, what are you really asking? Are you trying to say that we don't have the evidence? If so, I agree. We don't have the cure. Are you trying to say that you don't believe that a cure can be achieved? If so, I disagree and think that we will have therapies that will regenerate and restore function in people with chronic spinal cord injury.

[kivi66]

Dr.Wise, what for so many emotions, exaggerations and wrong assumptions,-my purpose is getting the most objective assessment of the current situation, so, thank you for the reply.

Originally Posted by quadfather

kivi,
What is your native language? Perhaps use that, so others can translate on your behalf.

quadfather, I don't think you'll do favor to yourself by having to translate from Ukrainian.

Originally Posted by Jim

They speak the truth is San Fran!

Sure, especially the ones dwelling in The Castro.

t8burst, please, stop yapping.

[t8burst]

Originally Posted by kivi66

Dr.Wise, what for so many emotions, exaggerations and wrong assumptions,-my purpose is getting the most objective assessment of the current situation, so, thank you for the reply.

quadfather, I don't think you'll do favor to yourself by having to translate from Ukrainian.

Sure, especially the ones dwelling in The Castro.

t8burst, please, stop yapping.

Nice! The thinly veiled anti-homosexual slur. You are an ass on multiple fronts.

[Wise Young]

Please stop the name-calling. Thank you. Wise.

[t8burst]

Originally Posted by Wise Young

Please stop the name-calling. Thank you. Wise.

Sorry Wise, I don't respond well to bigotry. Frontal lobe problem I will stop.

[kivi66]

You see, Jim, the impulse passed and everybody at once got better, irrespective of dwelling place, native language, sexual preferences and even frontal lobe problem. So, all is well that ends well. And, generally speaking, t8burst, I partly agree with you that dogs can at times be better than humans, even the ones residing in The Castro.

[paolocipolla]

T8burts, be nicer, you should be a moderator here

[t8burst]

Originally Posted by paolocipolla

T8burts, be nicer, you should be a moderator here

I should and try but I am like all of us, I have my good days and my bad. Sometimes when I feel like I am sitting with my feet in a pool of acid I don't temper my responses. Being a moderator I see the incredible amount of time and effort Wise puts into running this site and it annoys me when he is not treated with respect. People certainly have the right to ask questions but if they aren't done in a respectful way, moderator or not I will respond. In the future I will just do it without name calling.

[kivi66]

Dr.Wise, one more unnoticed by you query:

Originally Posted by Wise Young

Most of the doctors and scientists who claim to be studying mesenchymal stem cells have not done the rigorous analyses of their cells to show that they are studying mesenchymal stem cells. Stromal cells are of course the cells in bone marrow, which include mesenchymal stem cells, as well as hematopoietic stem cells, and also pluripotent stem cells.
Wise.

Originally Posted by kivi66

"As a proof of principle, we focused on mesenchymal stem cells because of their extensive use in regenerative medicine," says Izpisua Belmonte. "Lamin A mutations mainly effect mesoderm-derived tissues, thus gene-editing in these cells could be an attractive therapeutic option." (http://www.medicalnewstoday.com/releases/225947.php)

Dr.Wise, what's your opinion about this "mesenchymal study"?