Stem Cell Articles - Page 487

manouli · 02-22-2012, 02:59 PM

An Irish Stem Cell Perspective

The Irish Stem Cell Foundation recently held a conference in Dublin to discuss the state of research at home and abroad. During one of the more interesting sessions, Chief science officer Stephen Sullivan introduced Martin Codyre, who suffered a devastating spinal cord injury three years ago.

Codyre is also an engineer by training, which makes him a fascinasting patient advocate. In particular, he discusses the ever growing number of unregulated sham stem cell therapies being peddled to the public and why patient advocates need to be more involved in exposing them.

http://www.forbes.com/sites/johnfarr...l-perspective/

manouli · 02-22-2012, 07:08 PM

FEB. 22, 2012

Scientists trigger muscle stem cells to divide
BY KRISTA CONGER

Thomas Rando

A tiny piece of RNA plays a key role in determining when muscle stem cells from mice activate and start to divide, according to researchers at the Stanford University School of Medicine. The finding may help scientists learn how to prepare human muscle stem cells for use in therapies for conditions such as muscular dystrophy and aging by controlling their activation state.

It’s the first time that a small regulatory RNA, called a microRNA, has been implicated in the maintenance of the adult stem cell resting, or quiescent, state.

“Although on the surface the quiescent state seems to be relatively static, it’s quite actively maintained,” said Thomas Rando, MD, PhD, professor of neurology and neurological sciences. “We’ve found that changing the levels of just one specific microRNA in resting muscle stem cells, however, causes them to spring into action.”

Rando, who is also the director of Stanford’s Glenn Laboratories for the Biology of Aging and the deputy director of the Stanford Center on Longevity, is the senior author of the research, published Feb. 23 in Nature. Postdoctoral scholar Tom Cheung, PhD, is the first author of the study.

Unlike stem cells in the blood or skin, muscle stem cells spend most of their lives nestled in the surrounding tissue. “They don’t do much most of the time,” said Rando. “They remain in a quiescent state for most of a person’s life. When you injure your muscle, however, they begin dividing to repair the damage.” Like all adult stem cells, each muscle stem cell becomes two daughter cells: one with stem cell properties, and the other that continues dividing to become mature muscle cells and fibers to replenish those that are damaged. Without such “asymmetric” division, the stem cells would quickly be depleted after injury.

read...

http://med.stanford.edu/ism/2012/february/rando.html

manouli · 02-24-2012, 07:59 PM

Researchers find stem cells reduce Parkinson in monkey

The Yomiuri Shimbun, The Asia News Network | Thu, 02/23/2012 10:32 AM

Japanese researchers have been able to improve the symptoms of Parkinson's disease in monkeys by transplanting nerve cells derived from embryonic stem cells into their brains, the team has announced.

The finding is the world's first reported success of its kind with a primate, according to the research team led by associate professor Jun Takahashi of Kyoto University's Institute for Frontier Medical Sciences. It has been released in the online edition of US journal Stem Cells.

After the transplant, the monkeys, which had been almost unable to move, showed improvements in their symptoms to the point where they became able to walk on their own, the team said.

read...

http://www.thejakartapost.com/news/2...-symptoms.html

manouli · 02-25-2012, 07:25 PM

Study: brain memory formation, stem cell development linked

A new study conducted by researchers at the RIKEN-MIT Center for Neural Circuit Genetics has revealed the mystery the brain memory formation.

Scientists found that brain memory formation is triggered by stem cell development in both remembering new memories and maintaining older ones.

“Specific neurons in a brain region called the dentate gyrus serve distinct roles in memory formation depending on whether the neural stem cells that produced them were of old versus young age,” they explained.

Experts believe that discovering the link between the cellular basis of memory formation and the birth of new neurons could grant a new class of drug targets to treat memory disorders.

more...

http://presstv.com/detail/228587.html

manouli · 02-26-2012, 07:52 PM

New study suggests women have continuous supply of eggs in ovary stem cells
From: The Australian
February 27, 2012 9:27AM

AN experiment that produced human eggs from stem cells could one day be a boon for women who are desperate to have a baby, a newly-published study says.

The work sweeps away the belief that a woman has only a limited stock of eggs and replaces it with the theory that the supply is continuously replenished from precursor cells in the ovary, its authors said.

"The prevailing dogma in our field for the better part of the last 50 or 60 years was that young girls at birth were given a bank account of eggs at birth that's not renewable," said Jonathan Tilly, director of the Vincent Center for Reproductive Biology at Massachusetts General Hospital, who led the research.

more...

http://www.theaustralian.com.au/news...-1226282328254

manouli · 02-26-2012, 07:56 PM

Seminar to focus on stem cell research development
The latest discoveries and promises of stem cell research and the development of new therapeutic approaches for a variety of diseases will be in focus at the Qatar International Conference on Stem Cell Science and Policy 2012 which begins today.

The four-day event, being held at Qatar National Convention Centre, is a milestone in Qatar Foundation’s ongoing collaboration with the James A Baker III Institute for Public Policy at Rice University, Houston, Texas, US.
The aim of QF’s joint initiative with the Baker Institute’s International Programme on Stem Cell Science Policy is to develop stem cell research in Qatar as well as to find ways to address the shared challenges of community support for stem cell research in Doha and Houston.
To accomplish this goal, the programme has supported several events since its inception, including meetings, workshops, and training programmes in both cities.

more...

http://www.gulf-times.com/site/topic...6&parent_id=16

manouli · 02-28-2012, 02:37 PM

Eggs made from stem cells could treat more than just fertility

By Karen Kaplan, Los Angeles Times/For the Booster Shots blog
7:06 p.m. EST, February 27, 2012

In a new study, Harvard researchers say they have found stem cells in women that can be used to grow new eggs. Not surprisingly, this has raised much discussion about whether a woman’s biological clock can be stopped – why worry about running out of eggs if you can just make new ones whenever you need them?

The work described in the paper, published online Sunday by the journal Nature Medicine, is still a long way from being useful to women in need of fertility treatments. And many scientists remain skeptical that these ovarian stem cells really can mature into healthy eggs.

But as long as we’re in the pie-in-the-sky realm, let’s consider another way that the ability to grow an abundant supply of eggs would be helpful: to make human embryonic stem cell lines that would be perfectly matched to patients.

more...

http://www.sun-sentinel.com/health/l...,1429234.story

manouli · 02-29-2012, 06:27 PM

'Survivor''s Ethan Zohn Gets Stem Cell Transplant

February 29, 2012
Survivor winner Ethan Zohn underwent a stem-cell transplant on Wednesday from one of his brothers in his continuing battle with Hodgkin's lymphoma.

Ethan's longtime girlfriend Jenna Morasca, who is staying with him in the hospital, tells People.com that they had returned to the same ward where they stayed when Zohn was first diagnosed two years ago. "No one wants to come back here," Jenna said. "Even though the nurses and doctors are wonderful, this is one place where you really don't want to see anybody ever again."

read...

http://www.etonline.com/news/119483_...ll_Transplant/

manouli · 02-29-2012, 06:30 PM

Stem Cell Pioneers Converge in Portland to Discuss and Celebrate a Revolutionary New Stem Cell Enter

Medistem Inc. (PINKSHEETS: MEDS) announced today its Annual "Evening with Medistem" Event will take place in Portland, Oregon on March 7th, 2012. The event is being hosted by Vladimir Zaharchook, Vice Chairman at Medistem, Inc., and will feature stem cell luminaries and pioneers working with Medistem including Dr. Amit Patel, Director of Regenerative Medicine at University of Utah and the first person to administer stem cells into patients with heart failure, Dr. Michael Murphy, Vascular Surgeon at Indiana University and Principal Investigator for Medistem's FDA clinical trial in patients with risk of amputation, and Dr. Alan Lewis, former CEO of the Juvenile Diabetes Research Foundation, advisory board member of Medistem.

read...

http://pr-usa.net/index.php?option=c...6785&Itemid=29

manouli · 03-01-2012, 10:47 AM

Scientists make groundbreaking discovery on stem cell regulation
March 1, 2012

A*STAR scientists have for the first time, identified that precise regulation of polyamine levels is critical for embryonic stem cell (ESC) self-renewal – the ability of ESCs to divide indefinitely – and directed differentiation. This paper is crucial for better understanding of ESC regulation and was published in the journal Genes & Development on March 1 by the team of scientists from the Institute of Medical Biology (IMB), a research institute under the Agency for Science, Technology and Research.

Embryonic stem cells hold great potential for the development of cellular therapies, where stem cells are used to repair tissue damaged by disease or trauma. This is due to their unique ability to renew themselves and differentiate into any specific types of cell in the body. One of the challenges with cellular therapies is ensuring that ESCs are fully and efficiently differentiated into the correct cell type. This study sheds light on understanding how ESCs are regulated, which is essential to overcome these challenges and turn the vision of cell therapies into reality

read...

http://www.physorg.com/news/2012-03-...stem-cell.html

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02-22-2012, 02:59 PM	#4861
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	An Irish Stem Cell Perspective The Irish Stem Cell Foundation recently held a conference in Dublin to discuss the state of research at home and abroad. During one of the more interesting sessions, Chief science officer Stephen Sullivan introduced Martin Codyre, who suffered a devastating spinal cord injury three years ago. Codyre is also an engineer by training, which makes him a fascinasting patient advocate. In particular, he discusses the ever growing number of unregulated sham stem cell therapies being peddled to the public and why patient advocates need to be more involved in exposing them. http://www.forbes.com/sites/johnfarr...l-perspective/

02-22-2012, 07:08 PM	#4862
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	FEB. 22, 2012 Scientists trigger muscle stem cells to divide BY KRISTA CONGER Thomas Rando A tiny piece of RNA plays a key role in determining when muscle stem cells from mice activate and start to divide, according to researchers at the Stanford University School of Medicine. The finding may help scientists learn how to prepare human muscle stem cells for use in therapies for conditions such as muscular dystrophy and aging by controlling their activation state. It’s the first time that a small regulatory RNA, called a microRNA, has been implicated in the maintenance of the adult stem cell resting, or quiescent, state. “Although on the surface the quiescent state seems to be relatively static, it’s quite actively maintained,” said Thomas Rando, MD, PhD, professor of neurology and neurological sciences. “We’ve found that changing the levels of just one specific microRNA in resting muscle stem cells, however, causes them to spring into action.” Rando, who is also the director of Stanford’s Glenn Laboratories for the Biology of Aging and the deputy director of the Stanford Center on Longevity, is the senior author of the research, published Feb. 23 in Nature. Postdoctoral scholar Tom Cheung, PhD, is the first author of the study. Unlike stem cells in the blood or skin, muscle stem cells spend most of their lives nestled in the surrounding tissue. “They don’t do much most of the time,” said Rando. “They remain in a quiescent state for most of a person’s life. When you injure your muscle, however, they begin dividing to repair the damage.” Like all adult stem cells, each muscle stem cell becomes two daughter cells: one with stem cell properties, and the other that continues dividing to become mature muscle cells and fibers to replenish those that are damaged. Without such “asymmetric” division, the stem cells would quickly be depleted after injury. read... http://med.stanford.edu/ism/2012/february/rando.html

02-24-2012, 07:59 PM	#4863
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	Researchers find stem cells reduce Parkinson in monkey The Yomiuri Shimbun, The Asia News Network \| Thu, 02/23/2012 10:32 AM Japanese researchers have been able to improve the symptoms of Parkinson's disease in monkeys by transplanting nerve cells derived from embryonic stem cells into their brains, the team has announced. The finding is the world's first reported success of its kind with a primate, according to the research team led by associate professor Jun Takahashi of Kyoto University's Institute for Frontier Medical Sciences. It has been released in the online edition of US journal Stem Cells. After the transplant, the monkeys, which had been almost unable to move, showed improvements in their symptoms to the point where they became able to walk on their own, the team said. read... http://www.thejakartapost.com/news/2...-symptoms.html

02-25-2012, 07:25 PM	#4864
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	Study: brain memory formation, stem cell development linked A new study conducted by researchers at the RIKEN-MIT Center for Neural Circuit Genetics has revealed the mystery the brain memory formation. Scientists found that brain memory formation is triggered by stem cell development in both remembering new memories and maintaining older ones. “Specific neurons in a brain region called the dentate gyrus serve distinct roles in memory formation depending on whether the neural stem cells that produced them were of old versus young age,” they explained. Experts believe that discovering the link between the cellular basis of memory formation and the birth of new neurons could grant a new class of drug targets to treat memory disorders. more... http://presstv.com/detail/228587.html

02-26-2012, 07:52 PM	#4865
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	New study suggests women have continuous supply of eggs in ovary stem cells From: The Australian February 27, 2012 9:27AM AN experiment that produced human eggs from stem cells could one day be a boon for women who are desperate to have a baby, a newly-published study says. The work sweeps away the belief that a woman has only a limited stock of eggs and replaces it with the theory that the supply is continuously replenished from precursor cells in the ovary, its authors said. "The prevailing dogma in our field for the better part of the last 50 or 60 years was that young girls at birth were given a bank account of eggs at birth that's not renewable," said Jonathan Tilly, director of the Vincent Center for Reproductive Biology at Massachusetts General Hospital, who led the research. more... http://www.theaustralian.com.au/news...-1226282328254

02-26-2012, 07:56 PM	#4866
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	Seminar to focus on stem cell research development The latest discoveries and promises of stem cell research and the development of new therapeutic approaches for a variety of diseases will be in focus at the Qatar International Conference on Stem Cell Science and Policy 2012 which begins today. The four-day event, being held at Qatar National Convention Centre, is a milestone in Qatar Foundation’s ongoing collaboration with the James A Baker III Institute for Public Policy at Rice University, Houston, Texas, US. The aim of QF’s joint initiative with the Baker Institute’s International Programme on Stem Cell Science Policy is to develop stem cell research in Qatar as well as to find ways to address the shared challenges of community support for stem cell research in Doha and Houston. To accomplish this goal, the programme has supported several events since its inception, including meetings, workshops, and training programmes in both cities. more... http://www.gulf-times.com/site/topic...6&parent_id=16

02-28-2012, 02:37 PM	#4867
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	Eggs made from stem cells could treat more than just fertility By Karen Kaplan, Los Angeles Times/For the Booster Shots blog 7:06 p.m. EST, February 27, 2012 In a new study, Harvard researchers say they have found stem cells in women that can be used to grow new eggs. Not surprisingly, this has raised much discussion about whether a woman’s biological clock can be stopped – why worry about running out of eggs if you can just make new ones whenever you need them? The work described in the paper, published online Sunday by the journal Nature Medicine, is still a long way from being useful to women in need of fertility treatments. And many scientists remain skeptical that these ovarian stem cells really can mature into healthy eggs. But as long as we’re in the pie-in-the-sky realm, let’s consider another way that the ability to grow an abundant supply of eggs would be helpful: to make human embryonic stem cell lines that would be perfectly matched to patients. more... http://www.sun-sentinel.com/health/l...,1429234.story

02-29-2012, 06:27 PM	#4868
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	'Survivor''s Ethan Zohn Gets Stem Cell Transplant February 29, 2012 Survivor winner Ethan Zohn underwent a stem-cell transplant on Wednesday from one of his brothers in his continuing battle with Hodgkin's lymphoma. Ethan's longtime girlfriend Jenna Morasca, who is staying with him in the hospital, tells People.com that they had returned to the same ward where they stayed when Zohn was first diagnosed two years ago. "No one wants to come back here," Jenna said. "Even though the nurses and doctors are wonderful, this is one place where you really don't want to see anybody ever again." read... http://www.etonline.com/news/119483_...ll_Transplant/

02-29-2012, 06:30 PM	#4869
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	Stem Cell Pioneers Converge in Portland to Discuss and Celebrate a Revolutionary New Stem Cell Enter Medistem Inc. (PINKSHEETS: MEDS) announced today its Annual "Evening with Medistem" Event will take place in Portland, Oregon on March 7th, 2012. The event is being hosted by Vladimir Zaharchook, Vice Chairman at Medistem, Inc., and will feature stem cell luminaries and pioneers working with Medistem including Dr. Amit Patel, Director of Regenerative Medicine at University of Utah and the first person to administer stem cells into patients with heart failure, Dr. Michael Murphy, Vascular Surgeon at Indiana University and Principal Investigator for Medistem's FDA clinical trial in patients with risk of amputation, and Dr. Alan Lewis, former CEO of the Juvenile Diabetes Research Foundation, advisory board member of Medistem. read... http://pr-usa.net/index.php?option=c...6785&Itemid=29

03-01-2012, 10:47 AM	#4870
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	Scientists make groundbreaking discovery on stem cell regulation March 1, 2012 A*STAR scientists have for the first time, identified that precise regulation of polyamine levels is critical for embryonic stem cell (ESC) self-renewal – the ability of ESCs to divide indefinitely – and directed differentiation. This paper is crucial for better understanding of ESC regulation and was published in the journal Genes & Development on March 1 by the team of scientists from the Institute of Medical Biology (IMB), a research institute under the Agency for Science, Technology and Research. Embryonic stem cells hold great potential for the development of cellular therapies, where stem cells are used to repair tissue damaged by disease or trauma. This is due to their unique ability to renew themselves and differentiate into any specific types of cell in the body. One of the challenges with cellular therapies is ensuring that ESCs are fully and efficiently differentiated into the correct cell type. This study sheds light on understanding how ESCs are regulated, which is essential to overcome these challenges and turn the vision of cell therapies into reality read... http://www.physorg.com/news/2012-03-...stem-cell.html