Stem Cell Articles - Page 359

manouli · 11-10-2009, 12:58 PM

Sigma-Aldrich Enters Distribution Agreement With Stemgent, Inc. to Offer Lentivirus-Based Gene Delivery Products for Regenerative Medicine and Stem Cell Research

ST. LOUIS, Nov. 10 /PRNewswire-FirstCall/ -- Sigma-AldrichÂ® (Nasdaq: SIAL) today announced that it has entered into an exclusive worldwide distribution agreement with Stemgent, Inc. to offer Stemgent's portfolio of lentivirus-based delivery systems for the generation of induced pluripotent stem (iPS) cells. This agreement expands Sigma-Aldrich's leading portfolio of advanced stem cell research technologies, available through the Company's web portal at http://www.sigma-aldrich.com/stemcell.

"Induced pluripotent stem cells have emerged as immensely useful tools for the modeling of human diseases, research and development of therapeutics, regenerative medicine and the development of personalized cell replacement therapies," commented Dr. David Smoller, Ph.D, President of Sigma-Aldrich's Research Biotech business unit. "Stemgent has made great strides developing lentivirus-based gene delivery vectors, and Sigma-Aldrich has made it a priority to provide products and services for the iPS cell research community."

more...

http://www.kmph.com/Global/story.asp...menu612_11_9_2

manouli · 11-10-2009, 08:27 PM

Opportunities in Human Embryonic Stem Cell (hESC) Products

Human embryonic stem cells (hESCs) are stem cells derived from the inner cell mass of a blastocyst, which is a stage reach 4-5 days post fertilization. They are the most pluripotent of all stem cell types and can develop into over 200 different cell types of the human body, providing tremendous therapeutic potential.

Human ESCs were first derived from mouse embryos in 1981 by Martin Evans and Matthew Kaufman, and independently by Gail R. Martin. In 1995, the first successful culturing of primate embryonic stem cells occurred at the University of Wisconsin-Madison. Another breakthrough followed at the University of Wisconsin-Madison in November 1998 when a group led by Dr. James Thomson developed a technique to isolate and grow human embryonic stem cells derived from human blastocysts.

more....

http://www.mindbranch.com/Opportunit...yonic-R3663-8/

manouli · 11-11-2009, 11:16 AM

Cord Blood Stem-cells Healed Little Girl | Print | E-mail
Written by Steven J. DuBord
Wednesday, 11 November 2009 01:50

Back in 2006, little Chloe Levine was born as the apparently healthy baby girl her parents had been waiting for. Sadly, before her first birthday, Chloe began to show signs of what turned out to be cerebral palsy. Only the fact that her parents had banked her umbilical cord blood — replete with stem cells — eventually saved Chloe.
The problems began at nine months. Chloe began keeping her right hand clenched in a fist and couldn’t hold her bottle or support her weight with her right arm. She would shuffle across the floor on her bottom while in a seated position.

It wasn’t until just after Chloe’s first birthday that the doctors finally found an answer to what was wrong. Chloe had suffered a stroke while she was still within her mother, and she had been born with cerebral palsy despite her initial healthy appearance.

“A part of me just died,” Chloe’s mother, Jenny, said about hearing the news. “At that point there was no cure for her, no treatment other than therapies — speech, physical and occupational therapy for the next 18 years. As parents, that was not fine. We wanted her to have as normal a life as possible; we didn’t want her to face a life of disability.”

more....

http://www.thenewamerican.com/index....ed-little-girl

manouli · 11-11-2009, 10:56 PM

Is A Cure For ALS Around the Corner?
November 11, 2009 - 1:25 PM | by: Reena Ninan

When New York Yankee Hall of Famer Lou Gehrig died from ALS (Amyotrophic Lateral Sclerosis also known as Lou Gehrig's disease) in 1941 there was no cure. Sixty-eight years later there is still no cure. The disease affects nerve cells in the brain and spinal cord, eventually paralyzing the body.

BrainStorm Cell Therapeutics Inc, a public U.S.-Israeli company that develops adult stem cell therapeutic products, may be on the verge of a significant breakthrough in ALS treatment. Fox's Middle East Correspondent Reena Ninan sat down with the company's chief scientist Prof. Daniel Offen, here are excerpts from the interview:

NINAN: What's the ALS breakthrough you're working on?

OFFEN: In our previous studies we have shown that our newly developed bone marrow derived stem cells can protect neurons in tissue cultures and in animal models. Recently, we found, in several experiments, that these unique cell populations can rescue motor neurons which are the cells that degenerate in ALS, as well.

NINAN: What makes you optimistic this will work with ALS patients?

more...

http://liveshots.blogs.foxnews.com/2...est=latestnews

manouli · 11-13-2009, 09:53 AM

Stem Cell Use In Regenerative Medicine May Also Be Bad For Health
Posted on: Friday, 13 November 2009, 07:51 CST

The use of stem cells in regenerative medicine is not always beneficial for human health, it may even be harmful according to a work done by the University of Granada and University of León. Scientists have demonstrated that transplantation of human mononuclear cells isolated from umbilical cord blood exerted a deleterious effect in rats with liver cirrhosis.

Researchers aimed to investigate whether the mononuclear cell fraction of human cord blood (HUCBM cells), which contains stem cells, might be useful in hepatic regenerative medicine. Both histological and biochemical findings obtained in this research suggest that cell transplantation did not improve the health of sick animals but it induced a hepatorenal syndrome instead.

read....

http://www.redorbit.com/news/health/...y_also_be_bad/

manouli · 11-14-2009, 12:01 PM

Two Units Of Umbilical Cord Blood Reduce Risk Of Leukemia Recurrence

ScienceDaily (Nov. 13, 2009) — A new study from the Masonic Cancer Center, University of Minnesota shows that patients who have acute leukemia and are transplanted with two units of umbilical cord blood (UCB) have significantly reduced risk of the disease returning. This finding has the potential to change the current medical practice of using one unit of UCB for treatment of patients who are at high risk for recurrence of leukemia and other cancers of the blood and bone marrow.

read....

http://www.sciencedaily.com/releases...1114080600.htm

manouli · 11-15-2009, 05:08 PM

Bulgarian Stem Cell Scientists Hope to Overcome Human Sterility
Society | November 15, 2009, Sunday

Bulgarian scientists are trying to produce human eggs or ova from stem cells, and if they succeed they would raise realistic hopes for the treatment of human sterility.

The research is being financed by the Bulgarian state as part of the efforts of the world scientific community in the application of stem cells for treatment of a variety of diseases.

Stem cells are extracted an embryo because they are the most basic cells out of which all tissue of the human body grows. The problem, however, is to discover what exactly makes one stem cell turn into a nerve cell, or a cardiac or genital cell.

Speaking at an open scientific symposium at Sofia University late on Saturday, Professor Rumen Pankov said that "the goal is to have the possibility of mature genital cells, both male and female, to reproduce, and eventually solve the problems with human sterility; or at least to research the problems that occur in formation of the normal so that we can find a cure for people who suffer from sterility".

more...

http://www.novinite.com/view_news.php?id=110000

manouli · 11-15-2009, 06:35 PM

Ethan's Stem Cells
Posted on: Sunday, November 15, 2009 - Daniel J. Vance
RSS Feed Print version ShareThis Post Comment

A bizarre series of events brought Kathy and Darren Raske into their current situation of possibly being able to advance medical science and improve their son's health.

Four years ago, Kathy was in her ninth month of pregnancy. Just prior to this, Darren's cousin had multiple leg injuries from being hit by an automobile. After having adult stem cell therapy (not using controversial embryonic stem cells) and going through physical therapy, his cousin miraculously began walking again.

So right before Kathy delivered, the Raskes, with Darren's cousin's experience in mind, chose to pay over a thousand dollars to have their future son's umbilical cord blood saved. It contained stem cells.

Kathy had a normal delivery. But when son Ethan was five weeks-old, doctors "did a battery of tests and found he had hypoplastic corpus collosum and hypoplastic optic nerve," said Kathy Raske in a telephone interview from her Florida home. "They said he had brain damage, and would be delayed, blind, and probably wouldn't feed."

In short, the fibers connecting Ethan's brain hemispheres and the section of his brain interpreting sight were underdeveloped. He went on to develop seizures, severe reflux, and lung disease from severe immune deficiency. Doctors diagnosed cerebral palsy, too.

Today, Ethan is four. The U.S. Food and Drug Administration won't allow the organization storing Ethan's umbilical cord blood to release it until a medical researcher chooses Ethan for a study that could help him.

more...

http://www.rocklintoday.com/news/tem...8332&zoneid=64

manouli · 11-16-2009, 11:03 AM

BrainStorm Stem Cell Therapy Technology Possesses Promising Potential for the Future Treatment of Multiple Sclerosis
Tagged with: Biotechnology Clinical Trials Health israel Middle East new york North America Product/Service Research science Stem Cells United States
Published Monday, November 16, 2009, 13:24 (Your-Story.org)

NEW YORK & PETACH TIKVAH, Israel–(BUSINESS WIRE)– BrainStorm Cell Therapeutics Inc. (OTCBB:BCLI), a leading developer of adult stem cell technologies and therapeutics, is pleased to announce that the company’s therapeutic approach for treating neurodegenerative diseases, particularly ALS and Parkinson’s disease, was found to have a positive effect in a mouse model of multiple sclerosis (MS).

In a scientific paper published in the Journal of Molecular Neuroscience, Professors Melamed and Offen’s team from Tel Aviv University studied the effectiveness of human bone marrow derived stem cells induced to differentiate and secrete neurotrophic factors (NTF-SC) as compared to the use of non-differentiated stem cells in a mouse MS model

read...

http://www.your-story.org/brainstorm...lerosis-52380/

manouli · 11-16-2009, 11:12 AM

Monday, November 16, 2009
ReNeuron Group presents positive pre-clinical data for CTX stem cell line therapy

Stem ReNeuron Group PLC (AIM: RENE) said it is presenting further positive pre-clinical efficacy data for its ReN009 stem cell therapy for peripheral arterial disease (PAD) at the American Heart Association (AHA) Scientific Sessions 2009 in Orlando, Florida, which will run until November 18.

The research was conducted by Professor Paolo Madeddu, chair of Experimental Cardiovascular Medicine and colleagues at the University of Bristol’s Heart Institute, and builds on earlier preliminary work conducted by that group.

In two studies, the researchers tested ReNeuron's lead CTX neural stem cell line, via intramuscular injection, in rats with restricted blood supply to the limbs (ischaemia). A range of doses were used across the studies, from 3,000 to 3 million cells per treatment. A significant and dose-dependent recovery of blood flow to the ischaemic limb was seen as soon as three days after administration, with significantly increased revascularisation of the damaged tissue after 21 days, as measured by increased capillary and arteriole density.

more....

http://www.proactiveinvestors.co.uk/...py--10209.html

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11-10-2009, 12:58 PM	#3581
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Sigma-Aldrich Enters Distribution Agreement With Stemgent, Inc. to Offer Lentivirus-Based Gene Delivery Products for Regenerative Medicine and Stem Cell Research ST. LOUIS, Nov. 10 /PRNewswire-FirstCall/ -- Sigma-AldrichÂ® (Nasdaq: SIAL) today announced that it has entered into an exclusive worldwide distribution agreement with Stemgent, Inc. to offer Stemgent's portfolio of lentivirus-based delivery systems for the generation of induced pluripotent stem (iPS) cells. This agreement expands Sigma-Aldrich's leading portfolio of advanced stem cell research technologies, available through the Company's web portal at http://www.sigma-aldrich.com/stemcell. "Induced pluripotent stem cells have emerged as immensely useful tools for the modeling of human diseases, research and development of therapeutics, regenerative medicine and the development of personalized cell replacement therapies," commented Dr. David Smoller, Ph.D, President of Sigma-Aldrich's Research Biotech business unit. "Stemgent has made great strides developing lentivirus-based gene delivery vectors, and Sigma-Aldrich has made it a priority to provide products and services for the iPS cell research community." more... http://www.kmph.com/Global/story.asp...menu612_11_9_2

11-10-2009, 08:27 PM	#3582
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Opportunities in Human Embryonic Stem Cell (hESC) Products Human embryonic stem cells (hESCs) are stem cells derived from the inner cell mass of a blastocyst, which is a stage reach 4-5 days post fertilization. They are the most pluripotent of all stem cell types and can develop into over 200 different cell types of the human body, providing tremendous therapeutic potential. Human ESCs were first derived from mouse embryos in 1981 by Martin Evans and Matthew Kaufman, and independently by Gail R. Martin. In 1995, the first successful culturing of primate embryonic stem cells occurred at the University of Wisconsin-Madison. Another breakthrough followed at the University of Wisconsin-Madison in November 1998 when a group led by Dr. James Thomson developed a technique to isolate and grow human embryonic stem cells derived from human blastocysts. more.... http://www.mindbranch.com/Opportunit...yonic-R3663-8/

11-11-2009, 11:16 AM	#3583
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Cord Blood Stem-cells Healed Little Girl \| Print \| E-mail Written by Steven J. DuBord Wednesday, 11 November 2009 01:50 Back in 2006, little Chloe Levine was born as the apparently healthy baby girl her parents had been waiting for. Sadly, before her first birthday, Chloe began to show signs of what turned out to be cerebral palsy. Only the fact that her parents had banked her umbilical cord blood — replete with stem cells — eventually saved Chloe. The problems began at nine months. Chloe began keeping her right hand clenched in a fist and couldn’t hold her bottle or support her weight with her right arm. She would shuffle across the floor on her bottom while in a seated position. It wasn’t until just after Chloe’s first birthday that the doctors finally found an answer to what was wrong. Chloe had suffered a stroke while she was still within her mother, and she had been born with cerebral palsy despite her initial healthy appearance. “A part of me just died,” Chloe’s mother, Jenny, said about hearing the news. “At that point there was no cure for her, no treatment other than therapies — speech, physical and occupational therapy for the next 18 years. As parents, that was not fine. We wanted her to have as normal a life as possible; we didn’t want her to face a life of disability.” more.... http://www.thenewamerican.com/index....ed-little-girl

11-11-2009, 10:56 PM	#3584
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Is A Cure For ALS Around the Corner? November 11, 2009 - 1:25 PM \| by: Reena Ninan When New York Yankee Hall of Famer Lou Gehrig died from ALS (Amyotrophic Lateral Sclerosis also known as Lou Gehrig's disease) in 1941 there was no cure. Sixty-eight years later there is still no cure. The disease affects nerve cells in the brain and spinal cord, eventually paralyzing the body. BrainStorm Cell Therapeutics Inc, a public U.S.-Israeli company that develops adult stem cell therapeutic products, may be on the verge of a significant breakthrough in ALS treatment. Fox's Middle East Correspondent Reena Ninan sat down with the company's chief scientist Prof. Daniel Offen, here are excerpts from the interview: NINAN: What's the ALS breakthrough you're working on? OFFEN: In our previous studies we have shown that our newly developed bone marrow derived stem cells can protect neurons in tissue cultures and in animal models. Recently, we found, in several experiments, that these unique cell populations can rescue motor neurons which are the cells that degenerate in ALS, as well. NINAN: What makes you optimistic this will work with ALS patients? more... http://liveshots.blogs.foxnews.com/2...est=latestnews

11-13-2009, 09:53 AM	#3585
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Stem Cell Use In Regenerative Medicine May Also Be Bad For Health Posted on: Friday, 13 November 2009, 07:51 CST The use of stem cells in regenerative medicine is not always beneficial for human health, it may even be harmful according to a work done by the University of Granada and University of León. Scientists have demonstrated that transplantation of human mononuclear cells isolated from umbilical cord blood exerted a deleterious effect in rats with liver cirrhosis. Researchers aimed to investigate whether the mononuclear cell fraction of human cord blood (HUCBM cells), which contains stem cells, might be useful in hepatic regenerative medicine. Both histological and biochemical findings obtained in this research suggest that cell transplantation did not improve the health of sick animals but it induced a hepatorenal syndrome instead. read.... http://www.redorbit.com/news/health/...y_also_be_bad/

11-14-2009, 12:01 PM	#3586
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Two Units Of Umbilical Cord Blood Reduce Risk Of Leukemia Recurrence ScienceDaily (Nov. 13, 2009) — A new study from the Masonic Cancer Center, University of Minnesota shows that patients who have acute leukemia and are transplanted with two units of umbilical cord blood (UCB) have significantly reduced risk of the disease returning. This finding has the potential to change the current medical practice of using one unit of UCB for treatment of patients who are at high risk for recurrence of leukemia and other cancers of the blood and bone marrow. read.... http://www.sciencedaily.com/releases...1114080600.htm

11-15-2009, 05:08 PM	#3587
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Bulgarian Stem Cell Scientists Hope to Overcome Human Sterility Society \| November 15, 2009, Sunday Bulgarian scientists are trying to produce human eggs or ova from stem cells, and if they succeed they would raise realistic hopes for the treatment of human sterility. The research is being financed by the Bulgarian state as part of the efforts of the world scientific community in the application of stem cells for treatment of a variety of diseases. Stem cells are extracted an embryo because they are the most basic cells out of which all tissue of the human body grows. The problem, however, is to discover what exactly makes one stem cell turn into a nerve cell, or a cardiac or genital cell. Speaking at an open scientific symposium at Sofia University late on Saturday, Professor Rumen Pankov said that "the goal is to have the possibility of mature genital cells, both male and female, to reproduce, and eventually solve the problems with human sterility; or at least to research the problems that occur in formation of the normal so that we can find a cure for people who suffer from sterility". more... http://www.novinite.com/view_news.php?id=110000

11-15-2009, 06:35 PM	#3588
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Ethan's Stem Cells Posted on: Sunday, November 15, 2009 - Daniel J. Vance RSS Feed Print version ShareThis Post Comment A bizarre series of events brought Kathy and Darren Raske into their current situation of possibly being able to advance medical science and improve their son's health. Four years ago, Kathy was in her ninth month of pregnancy. Just prior to this, Darren's cousin had multiple leg injuries from being hit by an automobile. After having adult stem cell therapy (not using controversial embryonic stem cells) and going through physical therapy, his cousin miraculously began walking again. So right before Kathy delivered, the Raskes, with Darren's cousin's experience in mind, chose to pay over a thousand dollars to have their future son's umbilical cord blood saved. It contained stem cells. Kathy had a normal delivery. But when son Ethan was five weeks-old, doctors "did a battery of tests and found he had hypoplastic corpus collosum and hypoplastic optic nerve," said Kathy Raske in a telephone interview from her Florida home. "They said he had brain damage, and would be delayed, blind, and probably wouldn't feed." In short, the fibers connecting Ethan's brain hemispheres and the section of his brain interpreting sight were underdeveloped. He went on to develop seizures, severe reflux, and lung disease from severe immune deficiency. Doctors diagnosed cerebral palsy, too. Today, Ethan is four. The U.S. Food and Drug Administration won't allow the organization storing Ethan's umbilical cord blood to release it until a medical researcher chooses Ethan for a study that could help him. more... http://www.rocklintoday.com/news/tem...8332&zoneid=64

11-16-2009, 11:03 AM	#3589
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	BrainStorm Stem Cell Therapy Technology Possesses Promising Potential for the Future Treatment of Multiple Sclerosis Tagged with: Biotechnology Clinical Trials Health israel Middle East new york North America Product/Service Research science Stem Cells United States Published Monday, November 16, 2009, 13:24 (Your-Story.org) NEW YORK & PETACH TIKVAH, Israel–(BUSINESS WIRE)– BrainStorm Cell Therapeutics Inc. (OTCBB:BCLI), a leading developer of adult stem cell technologies and therapeutics, is pleased to announce that the company’s therapeutic approach for treating neurodegenerative diseases, particularly ALS and Parkinson’s disease, was found to have a positive effect in a mouse model of multiple sclerosis (MS). In a scientific paper published in the Journal of Molecular Neuroscience, Professors Melamed and Offen’s team from Tel Aviv University studied the effectiveness of human bone marrow derived stem cells induced to differentiate and secrete neurotrophic factors (NTF-SC) as compared to the use of non-differentiated stem cells in a mouse MS model read... http://www.your-story.org/brainstorm...lerosis-52380/

11-16-2009, 11:12 AM	#3590
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Monday, November 16, 2009 ReNeuron Group presents positive pre-clinical data for CTX stem cell line therapy Stem ReNeuron Group PLC (AIM: RENE) said it is presenting further positive pre-clinical efficacy data for its ReN009 stem cell therapy for peripheral arterial disease (PAD) at the American Heart Association (AHA) Scientific Sessions 2009 in Orlando, Florida, which will run until November 18. The research was conducted by Professor Paolo Madeddu, chair of Experimental Cardiovascular Medicine and colleagues at the University of Bristol’s Heart Institute, and builds on earlier preliminary work conducted by that group. In two studies, the researchers tested ReNeuron's lead CTX neural stem cell line, via intramuscular injection, in rats with restricted blood supply to the limbs (ischaemia). A range of doses were used across the studies, from 3,000 to 3 million cells per treatment. A significant and dose-dependent recovery of blood flow to the ischaemic limb was seen as soon as three days after administration, with significantly increased revascularisation of the damaged tissue after 21 days, as measured by increased capillary and arteriole density. more.... http://www.proactiveinvestors.co.uk/...py--10209.html