Stem Cell Articles - Page 283

manouli · 01-19-2009, 01:08 AM

Glasgow to pioneer stem cell stroke treatment
MARTIN WILLIAMS January 19 2009

NEW HOPE: Anne Young may be involved in eye surgery techniques being pioneered in Edinburgh and Glasgow.
It failed to get approval in the US, over safety concerns, but yesterday it emerged UK human trials on experimental stem cell treatment for stroke patients will go ahead.

Glasgow is to become the centre for the pioneering research into the effectiveness of transplanting stem cells made from human foetal tissue into the brains of stroke patients.

It emerged last night that ReNeuron, the Guildford-based stem cell research company championing the research, has been given approval from the UK Medicines and Healthcare Products Agency after being frustrated by the lack of progress in getting the nod in the US.

ReNeuron went to the US Food and Drug Administration (FDA) for approval for human trials on 12 stroke patients as early as November 2006, but has been kept on hold ever since as regulators were unhappy with the data provided over the safety of the treatment.

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ReNeuron had hoped the issues could be addressed and they would be able to get the treatment to patients last year. The company's founder, Dr John Sinden, said: "We're here to prove in this first trial that everything's safe and it's straightforward and patients can accept this kind of treatment."

more..

http://www.theherald.co.uk/news/news..._treatment.php

manouli · 01-19-2009, 01:12 AM

Stem cell eye surgery to be tried

The procedure will transplant cells onto the cornea
A new surgical treatment offering hope to patients with corneal blindness is to be trialled in Scotland.

Doctors in Edinburgh and Glasgow will work together using an innovative technique involving adult stem cells.

About 20 patients will take part in the initial tests, using cells cultivated before being transplanted onto the surface of the cornea.

Millions of people worldwide suffer from corneal blindness, 80% of whom are elderly.

more..

http://news.bbc.co.uk/2/hi/uk_news/scotland/7836518.stm

manouli · 01-19-2009, 03:13 PM

Doctors hit back in row over stem cells

DOCTORS today defended controversial stem cell research into treatment for stroke victims.

It's hoped to launch the world's first trial of the treatment on patients at Glasgow's Southern General Hospital later this year.

But the procedure, which uses cells grown from an aborted foetus, has been criticised by the Catholic Church, and must still pass an ethics committee.

advertisement
The trials will see stem cells injected into the brains of patients to discover if the treatment can effectively regenerate damaged areas.

The treatment was developed by English-based firm ReNeuron.

more....

http://www.eveningtimes.co.uk/news/d...stem_cells.php

manouli · 01-20-2009, 08:30 AM

Osteoarthritis stem cell trial approved
Mesoblast to conduct world’s first stem cell trial for ACL-related osteoarthritis
Kate McDonald (Australian Life Scientist) 20/01/2009 12:27:00

Stem cell developer Mesoblast has received approval to begin a Phase II trial of its RepliCart knee cartilage product to slow or prevent the development of osteoarthritis after knee reconstruction.

The world-first trial will involve 24 patients between the ages of 18 and 40 who have had surgery to repair the anterior cruciate ligament in the last six months.

more...

http://www.biotechnews.com.au/articl...trial_approved

manouli · 01-20-2009, 08:31 AM

Lion gets stem cell treatment for a new life

COLORADO SPRINGS, COLO. -- One lion has a new life thanks to a very tricky surgery.

Elisa is a 23-year-old mountain lion in Woodland Park. It is the oldest lion in protective care. Elisa was rescued nearly a decade ago where she was on a photography exhibition. Her new owner takes care of her and lets her roam freely, but age has started to deteriorate her condition. She suffers from osteoarthritis in both elbows whick limits her activity and comfort level.

more...

http://www.coloradoconnection.com/ne...aspx?id=248411

manouli · 01-20-2009, 08:39 AM

Stem cells provide blood breakthrough
Andy Coghlan | New Scientist magazine
January 20, 2009

Blood donations may one day be a thing of the past thanks to the creation of the first functional red blood cells grown in the lab. The cells were grown from human embryonic stem cells (ESCs).

"You wouldn't have to worry about shortages because you could create as many as you want," says Robert Lanza, chief scientist at Advanced Cell Technology, the company that grew the red blood cells in Worcester, Mass.

The breakthrough raises the prospect of mass-producing supplies of the "universal donor" blood type O-negative, which is prized because it can be safely transfused into any patient, whatever their blood group. This type of blood is in short supply -- around 8 percent of Caucasians have it, and just 0.3 percent of Asians.

Making blood from a few ESC lines instead of obtaining it from countless donors may also help to stop the spread of disease, as it is easier to ensure such artificial blood is free of pathogens such as HIV and the viruses that cause hepatitis.

more...

http://www.orlandosentinel.com/featu...C7952059.story

manouli · 01-20-2009, 08:09 PM

Novel cell lines propel the search for safer stem cell induction
Published on 20 January 2009, 15:19 Last Update: 2 hour(s) ago by Insciences

CAMBRIDGE, Mass. (Jan. 19, 2009) — Whitehead Institute researchers have reliably produced mice and mouse cell lines with identical configurations of the specific factors needed to reprogram adult cells to an embryonic-stem-cell-like state. These so-called transgenic mice and mouse cell lines may be used to screen for potential drug substitutes for virally-inserted reprogramming genes and as a tool for unraveling how reprogramming works.

Currently, reprogramming adult cells usually requires one or more viruses to transfer the necessary reprogramming genes (Oct4, Sox2, Klf4 and c-Myc) into the cells’ DNA. Once activated, these genes convert the cells from their adult, differentiated status to an embryonic-like state.

However, this method poses significant risks for potential use in humans. The viruses used in reprogramming are associated with cancer because they may insert DNA anywhere in a cell’s genome, thereby potentially triggering the expression of cancer-causing genes, or oncogenes. In addition, the reprogramming gene c-Myc is a known oncogene and its insertion into a cell’s genome can also cause cancer.

more...

http://insciences.org/article.php?article_id=1576

manouli · 01-20-2009, 08:41 PM

Immediate Allogeneic Stem Cell Transplantation for Relapsed Adult ALL Successful

Researchers from Germany have reported that patients with relapsed acute lymphoblastic leukemia (ALL) who proceed directly to allogeneic stem cell transplant have better outcomes than patients who receive re-induction chemotherapy prior to transplantation. The details of this study appeared in the December 2008 issue of Bone Marrow Transplantation.[1]

Allogeneic stem cell transplantation from a related or unrelated donor or by using umbilical cord blood offers the best chance of long-term disease-free survival in patients with relapsed ALL. A large study recently reported that patients with adult ALL who receive a related or unrelated donor stem cell transplant in other than first complete remission have a long-term disease-free survival of 27%.[2] The conventional approach to treating relapsed patients with ALL is to give chemotherapy to induce a remission prior to transplantation. However, this approach has significant problems as patients who do not respond are often in worse condition prior to transplantation and may be more resistant to the transplant regimen. However, in many occasions chemotherapy has to be administered while seeking an appropriate donor.

more...

http://professional.cancerconsultant....aspx?id=43098

manouli · 01-21-2009, 10:11 AM

Russian Hemabank Develops New Cell Technology Based on Cord Blood
by M Dee Dubroff

Hemabank recently celebrated its fifth anniversary as the combination laboratory and storage facility for cell materials, where scientists create technologies for isolating stem cells from the cord blood

, which is collected at delivery. Today, only 0.33% of child deliveries in Russia are accompanied with the extraction of cord blood for further isolation and storage of stem cells. This figure is significantly lower than Germany (1.9%) and the United States (5%).

more...

http://inventorspot.com/articles/rus...rd_blood_22516

Max · 01-21-2009, 07:14 PM

Where funds will stem from

In this section »

A firm supporter of stem cell research, Barack Obama says: 'Instead of creating roadblocks, we must all work together to expand federal funding of stem cell research.'
Photograph: The Irish Times

DARA GANTLY

Scientists believe that one of Barack Obama’s first actions as US president will be to lift the restrictions on stem cell research funding
ONE OF Ireland’s leading medico-legal experts has described as “very significant” suggestions that one of the first actions to be taken by the new US president is likely to be the lifting of the restrictions on US federal funding of human embryonic stem cell (hESC) research.
Labelling the widely anticipated move by president-elect Barack Obama as a “very welcome development”, Dr Deirdre Madden, lecturer in the UCC Law Department, says the reversal of the Bush administration’s current policy on stem cell research clearly signalled Obama’s own personal conviction that embryonic stem cell research was potentially of vital importance to the development of new therapies and cures for patients suffering with a range of debilitating illnesses.

http://www.irishtimes.com/newspaper/...059660918.html

01-21-2009, 07:14 PM	#2830
Max Senior Member Join Date: Jul 2001 Location: Montreal,Province of Quebec, CANADA Posts: 15,036	Where funds will stem from Where funds will stem from In this section » Checking the list twice Hair at root of problem Lifelines A firm supporter of stem cell research, Barack Obama says: 'Instead of creating roadblocks, we must all work together to expand federal funding of stem cell research.' Photograph: The Irish Times DARA GANTLY Scientists believe that one of Barack Obama’s first actions as US president will be to lift the restrictions on stem cell research funding ONE OF Ireland’s leading medico-legal experts has described as “very significant” suggestions that one of the first actions to be taken by the new US president is likely to be the lifting of the restrictions on US federal funding of human embryonic stem cell (hESC) research. Labelling the widely anticipated move by president-elect Barack Obama as a “very welcome development”, Dr Deirdre Madden, lecturer in the UCC Law Department, says the reversal of the Bush administration’s current policy on stem cell research clearly signalled Obama’s own personal conviction that embryonic stem cell research was potentially of vital importance to the development of new therapies and cures for patients suffering with a range of debilitating illnesses. http://www.irishtimes.com/newspaper/...059660918.html __________________ http://stores.ebay.com/MAKSYM-Variety-Store

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01-19-2009, 01:08 AM	#2821
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Glasgow to pioneer stem cell stroke treatment MARTIN WILLIAMS January 19 2009 NEW HOPE: Anne Young may be involved in eye surgery techniques being pioneered in Edinburgh and Glasgow. It failed to get approval in the US, over safety concerns, but yesterday it emerged UK human trials on experimental stem cell treatment for stroke patients will go ahead. Glasgow is to become the centre for the pioneering research into the effectiveness of transplanting stem cells made from human foetal tissue into the brains of stroke patients. It emerged last night that ReNeuron, the Guildford-based stem cell research company championing the research, has been given approval from the UK Medicines and Healthcare Products Agency after being frustrated by the lack of progress in getting the nod in the US. ReNeuron went to the US Food and Drug Administration (FDA) for approval for human trials on 12 stroke patients as early as November 2006, but has been kept on hold ever since as regulators were unhappy with the data provided over the safety of the treatment. advertisement ReNeuron had hoped the issues could be addressed and they would be able to get the treatment to patients last year. The company's founder, Dr John Sinden, said: "We're here to prove in this first trial that everything's safe and it's straightforward and patients can accept this kind of treatment." more.. http://www.theherald.co.uk/news/news..._treatment.php

01-19-2009, 01:12 AM	#2822
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Stem cell eye surgery to be tried The procedure will transplant cells onto the cornea A new surgical treatment offering hope to patients with corneal blindness is to be trialled in Scotland. Doctors in Edinburgh and Glasgow will work together using an innovative technique involving adult stem cells. About 20 patients will take part in the initial tests, using cells cultivated before being transplanted onto the surface of the cornea. Millions of people worldwide suffer from corneal blindness, 80% of whom are elderly. more.. http://news.bbc.co.uk/2/hi/uk_news/scotland/7836518.stm

01-19-2009, 03:13 PM	#2823
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Doctors hit back in row over stem cells DOCTORS today defended controversial stem cell research into treatment for stroke victims. It's hoped to launch the world's first trial of the treatment on patients at Glasgow's Southern General Hospital later this year. But the procedure, which uses cells grown from an aborted foetus, has been criticised by the Catholic Church, and must still pass an ethics committee. advertisement The trials will see stem cells injected into the brains of patients to discover if the treatment can effectively regenerate damaged areas. The treatment was developed by English-based firm ReNeuron. more.... http://www.eveningtimes.co.uk/news/d...stem_cells.php

01-20-2009, 08:30 AM	#2824
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Osteoarthritis stem cell trial approved Mesoblast to conduct world’s first stem cell trial for ACL-related osteoarthritis Kate McDonald (Australian Life Scientist) 20/01/2009 12:27:00 Stem cell developer Mesoblast has received approval to begin a Phase II trial of its RepliCart knee cartilage product to slow or prevent the development of osteoarthritis after knee reconstruction. The world-first trial will involve 24 patients between the ages of 18 and 40 who have had surgery to repair the anterior cruciate ligament in the last six months. more... http://www.biotechnews.com.au/articl...trial_approved

01-20-2009, 08:31 AM	#2825
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Lion gets stem cell treatment for a new life COLORADO SPRINGS, COLO. -- One lion has a new life thanks to a very tricky surgery. Elisa is a 23-year-old mountain lion in Woodland Park. It is the oldest lion in protective care. Elisa was rescued nearly a decade ago where she was on a photography exhibition. Her new owner takes care of her and lets her roam freely, but age has started to deteriorate her condition. She suffers from osteoarthritis in both elbows whick limits her activity and comfort level. more... http://www.coloradoconnection.com/ne...aspx?id=248411

01-20-2009, 08:39 AM	#2826
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Stem cells provide blood breakthrough Andy Coghlan \| New Scientist magazine January 20, 2009 Blood donations may one day be a thing of the past thanks to the creation of the first functional red blood cells grown in the lab. The cells were grown from human embryonic stem cells (ESCs). "You wouldn't have to worry about shortages because you could create as many as you want," says Robert Lanza, chief scientist at Advanced Cell Technology, the company that grew the red blood cells in Worcester, Mass. The breakthrough raises the prospect of mass-producing supplies of the "universal donor" blood type O-negative, which is prized because it can be safely transfused into any patient, whatever their blood group. This type of blood is in short supply -- around 8 percent of Caucasians have it, and just 0.3 percent of Asians. Making blood from a few ESC lines instead of obtaining it from countless donors may also help to stop the spread of disease, as it is easier to ensure such artificial blood is free of pathogens such as HIV and the viruses that cause hepatitis. more... http://www.orlandosentinel.com/featu...C7952059.story

01-20-2009, 08:09 PM	#2827
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Novel cell lines propel the search for safer stem cell induction Published on 20 January 2009, 15:19 Last Update: 2 hour(s) ago by Insciences CAMBRIDGE, Mass. (Jan. 19, 2009) — Whitehead Institute researchers have reliably produced mice and mouse cell lines with identical configurations of the specific factors needed to reprogram adult cells to an embryonic-stem-cell-like state. These so-called transgenic mice and mouse cell lines may be used to screen for potential drug substitutes for virally-inserted reprogramming genes and as a tool for unraveling how reprogramming works. Currently, reprogramming adult cells usually requires one or more viruses to transfer the necessary reprogramming genes (Oct4, Sox2, Klf4 and c-Myc) into the cells’ DNA. Once activated, these genes convert the cells from their adult, differentiated status to an embryonic-like state. However, this method poses significant risks for potential use in humans. The viruses used in reprogramming are associated with cancer because they may insert DNA anywhere in a cell’s genome, thereby potentially triggering the expression of cancer-causing genes, or oncogenes. In addition, the reprogramming gene c-Myc is a known oncogene and its insertion into a cell’s genome can also cause cancer. more... http://insciences.org/article.php?article_id=1576

01-20-2009, 08:41 PM	#2828
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Immediate Allogeneic Stem Cell Transplantation for Relapsed Adult ALL Successful Researchers from Germany have reported that patients with relapsed acute lymphoblastic leukemia (ALL) who proceed directly to allogeneic stem cell transplant have better outcomes than patients who receive re-induction chemotherapy prior to transplantation. The details of this study appeared in the December 2008 issue of Bone Marrow Transplantation.[1] Allogeneic stem cell transplantation from a related or unrelated donor or by using umbilical cord blood offers the best chance of long-term disease-free survival in patients with relapsed ALL. A large study recently reported that patients with adult ALL who receive a related or unrelated donor stem cell transplant in other than first complete remission have a long-term disease-free survival of 27%.[2] The conventional approach to treating relapsed patients with ALL is to give chemotherapy to induce a remission prior to transplantation. However, this approach has significant problems as patients who do not respond are often in worse condition prior to transplantation and may be more resistant to the transplant regimen. However, in many occasions chemotherapy has to be administered while seeking an appropriate donor. more... http://professional.cancerconsultant....aspx?id=43098

01-21-2009, 10:11 AM	#2829
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Russian Hemabank Develops New Cell Technology Based on Cord Blood by M Dee Dubroff Hemabank recently celebrated its fifth anniversary as the combination laboratory and storage facility for cell materials, where scientists create technologies for isolating stem cells from the cord blood , which is collected at delivery. Today, only 0.33% of child deliveries in Russia are accompanied with the extraction of cord blood for further isolation and storage of stem cells. This figure is significantly lower than Germany (1.9%) and the United States (5%). more... http://inventorspot.com/articles/rus...rd_blood_22516