Stem Cell Articles - Page 200

manouli · 07-07-2008, 09:17 PM

Monday, July 7, 2008
Stem Cell Research Headed to Ballots
by Richard Piet

Stem cell research in the state could be closer to getting the green light as of Monday.

Proponents of the drive to permit stem cell research in Michigan think they have voters on their side.

"We may have set a record," says Larry Owen. "We're going to file more than 560-thousand signatures of Michigan citizens."

more....

http://wkzonews.blogspot.com/2008/07...o-ballots.html

manouli · 07-08-2008, 09:07 AM

Novel high-throughput automated stem cell culture & screening system

KINGSTON, England, July 8, 2008-A novel high-throughput automated stem cell culture and screening system is described in a new technical data sheet available from Velocity11 (Menlo Park, CA), an Agilent Technologies company.

The technical data sheet describes how an automated platform was developed with a customer who wanted to use stem cells as the basis of their HTS assays and drug discovery programs, with the goal to increase their throughput and potentially find more promising lead compounds. To successfully automate these sensitive assays they required an automated system with a controlled environment which would provide the best conditions for cell growth.

more...

http://www.pharmalive.com/News/index...&categoryid=15

manouli · 07-08-2008, 09:13 AM

July 08, 2008 06:30 AM Eastern Daylight Time

International Stem Cell Corporation Announces Collaboration with Michigan State University to Study Parthenogenetic Stem Cells

OCEANSIDE, Calif.--(BUSINESS WIRE)--International Stem Cell Corporation (OTCBB: ISCO) announced today a new collaboration with leading stem cell researcher Jose Cibelli at Michigan State University as part of ISCO’s ongoing strategy to work with scientific leaders across the world to expand the scientific data relating to parthenogenetic stem cells.

Professor Cibelli will study gene expression in several human parthenogenetic stem cell lines and compare the results with fertilized embryonic stem cells. According to Professor Cibelli, “We have observed in mouse and monkey that imprinting in parthenogenetic cells changes as the cells are cultured. This in vitro phenomenon can be advantageous for parthenogenetic cells.”

more...

http://www.businesswire.com/portal/s...02&newsLang=en

manouli · 07-08-2008, 09:49 PM

Can Stem Cells Combat Wrinkles?
Posted on: Tuesday, 8 July 2008, 12:15 CDT

Restore and renew.

"Significantly reduces the loss of cells in the epidermis."

"Regenerate cells and repair tissue."

The newest skin creams beckon with an air of scientific gravitas, holding out the hope that now, at last, medicine has triumphed over the visible aging process. With tantalizing biological references and understated packaging, the products are among the first to capitalize on the public's insatiable appetite for stem-cell technology.

"The goal of these products is to create a more youthful cell that would replenish elastin and collagen," says Dr. Kenneth Beer, a West Palm Beach, Fla., dermatologist. A clinical instructor at the University of Miami, he conducts clinical trials on skin-care products.

And, of course, what better way to do that than to harness stem cells, those potential miracles of self-repair and curative power on which society is pinning so many medical hopes?

But a word of caution before you plunk down $80 or $155 for these potions: They might be no better than existing anti-aging skin creams, the best of which spur the skin to work harder but still produce only modest effects. Adds Beer of the stem-cell-touting products' potential: "The notion that you could do that with a cream is a little bit ahead of itself. It's a great piece of marketing because there is so much interest in stem cells."

That's not to say that stem cells couldn't ultimately improve skin, perhaps in the next decade or so, says Dr. Leslie Baumann, a dermatology professor and director of the University of Miami's Cosmetic Center - but that time has not arrived, she says.

For now, consumers are being misled, she says. In fact, the creams don't even contain live stem cells - just the suggestion that they're comparable in some way to the much-heralded, but largely unharnessed, cellular powerhouses.

The stem-cell skin cream frenzy began last year when a Salt Lake City company called Voss Laboratories released its product, Amatokin, at Bloomingdale's with the advertising slogan "Stem Cells: The future of skin rejuvenation." It cost $190 for a 30-milliliter tube - about 1 ounce.

more...

http://www.redorbit.com/news/health/...les/index.html

manouli · 07-08-2008, 10:08 PM

Neurology Today:Volume 8(13)3 July 2008pp 1,8-9
STEM CELL TRANSPLANT EFFECTIVE FOR MNGIE
[AAN ANNUAL MEETING]
HURLEY, DAN

CHICAGO-Noteworthy clinical gains have resulted from an allogeneic stem cell transplantation in a patient with mitochondrial neurogastrointestinal encephalomyopathy, or MNGIE, a Columbia University neurologist reported at the AAN annual meeting here in April.

While the same team reported two years ago that transplantation had corrected the biochemical abnormalities in the serum of two patients, the new report offered the first evidence of clinical gains; one of the patients reached the 30-month post-transplant mark in starkly improved health.

MNGIE is an autosomal recessive disorder of intergenomic communication. Mutations in the thymidine phosphorylase gene of the patient's nuclear DNA causes a buildup of thymidine and deoxyuridine, explained Michio Hirano, MD, associate professor of neurology at Columbia University Medical Center, who was the lead author of the new report.

There's a cellular problem, Dr. Hirano said. The cells can't metabolize food substrates sufficiently…using anaerobic glycolysis, to convert sugars and fats into lactic acid rather than into carbon dioxide and water. We think the buildup of thymidine and deoxyuridine is toxic to mitochondria.

Dr. Hirano said he hopes the case will alert neurologists to be more vigilant in considering the possibility of MNGIE when faced with a patient with the syndrome of ophthalmoplegia, severe GI dysmotility, extreme cachexia, peripheral neuropathy, and leukoencephalopathy.

I cannot think of any other disease that has this combination of symptoms, but the condition remains under-recognized and under-diagnosed, he said. Most neurologists are unfamiliar with MNGIE. Frequently these patients go to gastroenterologists or psychiatrists and are misdiagnosed with anorexia nervosa, celiac disease, or inflammatory bowel disease. Every patient we've seen had been misdiagnosed with one of these conditions.

THE CASE
The patient, a 30-year-old Italian pharmacologist who weighed just 55 pounds on her 5'2 frame at the time of the procedure in October 2005, had reached 61 pounds by the AAN meeting and was gaining about a pound each month, Dr. Hirano reported. Her bowel movements became normal, foot dysesthesias had disappeared, and total parenteral nutrition had been replaced by a normal diet of 3,000 calories daily. Previously absent tendon reflexes returned at the biceps and triceps, and nerve conduction studies showed improvement in distal latencies and conduction velocities.

more...

http://www.neurotodayonline.com/pt/re/neurotoday/fulltext.00132985-200807030-00003.htm;jsessionid=L0pHmqGTTLC5m3LGQlppQ9W2SxxPR CssqpbDftyxfYnK0pdGQ0cv!218002192!181195629!8091!-1

manouli · 07-08-2008, 10:41 PM

Dr. breaks new ground by using stem cells on damaged hearts

08:08 PM CDT on Tuesday, July 8, 2008

Meg Farris / Eyewitness News Medical Reporter

Some people with heart failure, who have no more treatment options, are surprised to find out that there may be one last hope in Covington.

A local doctor is doing the only research of its kind with stem cells that could prove to be life saving for people with cardiovascular disease.

Aaron Cathcart’s heart was so damaged from years of high blood pressure that some doctors said he would not survive any treatment or surgery.

Video: Watch the Story
"He said he had never seen any body with a heart as bad as mine that was still living," Aaron recalled one doctor saying.

But Aaron’s daughter scoured the Internet and found one last hope for her father and surprisingly it was nearby – in Covington.

Dr. Gabriel Lasala, an interventional cardiologist, harvested some of Aaron's stem cells from his bone marrow.

The idea behind harvesting stem cells is that they can repair damaged tissue.

more...

http://www.wwltv.com/medical/stories....37dde8dd.html

manouli · 07-09-2008, 08:39 PM

California Stem Cell Research Panel Opposes Bill Making it Help Patients

by Steven Ertelt
LifeNews.com Editor
July 9, 2008

Sacramento, CA (LifeNews.com) -- The California panel created by Proposition 71 was supposed to benefit patients across the state by allowing scientists access to funds for research for cures. However, the committee funding by the initiative is opposing a bill in the state legislature to make it do just that.

The California Institute for Regenerative Medicine has emailed its supporters a dire-sounding letter saying its existence is threatened by legislative efforts to keep it accountable.

"We need you to take a few minutes to help save the California Institute for Regenerative Medicine and embryonic stem cell research in California. This is under siege right now in the state legislature," the group claims.

CIRM opposes Senate Bill 1565, which would require it to include in its intellectual property standards a requirement that each grantee and licensee submit for CIRM's approval a plan that will afford uninsured Californians access to any drug that is, in whole or in part, the result of research funded by the CIRM.

more...

http://www.lifenews.com/bio2505.html

manouli · 07-09-2008, 08:45 PM

New Technique Harvests Stem Cells at Earlier Stage
Research shows future production of new lines may be done without destroying embryo
Posted July 9, 2008

WEDNESDAY, July 9 (HealthDay News) -- Scientists say they have finally succeeded in developing human embryonic stem cells earlier in the development stage of a blastomere, or a 4-cell stage embryo, so the whole embryo is not destroyed.

The development, expected to be presented Wednesday at the European Society of Human Reproduction & Embryology annual conference in Barcelona, may make stem cell research easier to conduct by not raising as many ethical concerns, the researchers added.

more....

http://health.usnews.com/articles/he...ier-stage.html

manouli · 07-09-2008, 08:59 PM

Bio-Matrix Scientific Group, Inc. Announces Negotiations with Four Companies for Storage of Peripheral Blood Related Stem Cells
7/9/2008 @ 6:58 AM

Bio-Matrix Scientific Group, Inc. (OTCBB:BMSN) announced today that it is currently in negations with four companies to provide storage for peripheral blood related stem cell specimens. It is anticipated that, in the event that negotiations are successful, an excess of 15,000 specimens may be stored by the Company in the first year generating average revenue of $650 per specimen.

more...

http://www.freshnews.com/news/biotec...le_44344.html?

manouli · 07-09-2008, 09:06 PM

Spraying Stem Cells Heals Skin Faster

By medinews.com staff writers
Posted on 09 July 2008
A futuristic spray gun, similar in concept to an inkjet printer, sprays new infused skin onto a wound, essentially speeding up the healing process to a matter of hours.

Researchers at Wake Forest University Baptist Medical Center (Winston-Salem, NC, USA), the McGowan Institute for Regenerative Medicine (MIRM, Pittsburgh, PA, USA) and other institutions forming part of the U.S. Armed Forces Institute for Regenerative Medicine (AFIRM) are developing a handheld spray gun that spurts a thin layer of keratinocytes (immature skin cells) over deep skin wounds. The keratinocytes, harvested from the patient, are stored in cartridges along with a mix of growth factors and special nutrients; after being sprayed on the wound, they then “print” layers of skin tissue directly onto the wounds. The other essential part of the process is an innovative wound dressing; enmeshed in what looks like a traditional dressing is in reality a bioreactor; tubes extend from each end of the dressing, one doing the work of an artery, the other of a vein. When connected to an artificial vascular system the bioreactor bandage distributes glucose, sugar, amino acids, antibiotics, and electrolytes to the treated area. It cleans the wound, provides nutrition, and better supports the stem cells in the wound until they start to grow and regenerate new skin for the patient.

more...

http://www.medinews.com/GMEDTS32olcg...ritical%20Care

07-08-2008, 10:08 PM	#1995
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,338	Neurology Today:Volume 8(13)3 July 2008pp 1,8-9 STEM CELL TRANSPLANT EFFECTIVE FOR MNGIE [AAN ANNUAL MEETING] HURLEY, DAN CHICAGO-Noteworthy clinical gains have resulted from an allogeneic stem cell transplantation in a patient with mitochondrial neurogastrointestinal encephalomyopathy, or MNGIE, a Columbia University neurologist reported at the AAN annual meeting here in April. While the same team reported two years ago that transplantation had corrected the biochemical abnormalities in the serum of two patients, the new report offered the first evidence of clinical gains; one of the patients reached the 30-month post-transplant mark in starkly improved health. MNGIE is an autosomal recessive disorder of intergenomic communication. Mutations in the thymidine phosphorylase gene of the patient's nuclear DNA causes a buildup of thymidine and deoxyuridine, explained Michio Hirano, MD, associate professor of neurology at Columbia University Medical Center, who was the lead author of the new report. There's a cellular problem, Dr. Hirano said. The cells can't metabolize food substrates sufficiently…using anaerobic glycolysis, to convert sugars and fats into lactic acid rather than into carbon dioxide and water. We think the buildup of thymidine and deoxyuridine is toxic to mitochondria. Dr. Hirano said he hopes the case will alert neurologists to be more vigilant in considering the possibility of MNGIE when faced with a patient with the syndrome of ophthalmoplegia, severe GI dysmotility, extreme cachexia, peripheral neuropathy, and leukoencephalopathy. I cannot think of any other disease that has this combination of symptoms, but the condition remains under-recognized and under-diagnosed, he said. Most neurologists are unfamiliar with MNGIE. Frequently these patients go to gastroenterologists or psychiatrists and are misdiagnosed with anorexia nervosa, celiac disease, or inflammatory bowel disease. Every patient we've seen had been misdiagnosed with one of these conditions. THE CASE The patient, a 30-year-old Italian pharmacologist who weighed just 55 pounds on her 5'2 frame at the time of the procedure in October 2005, had reached 61 pounds by the AAN meeting and was gaining about a pound each month, Dr. Hirano reported. Her bowel movements became normal, foot dysesthesias had disappeared, and total parenteral nutrition had been replaced by a normal diet of 3,000 calories daily. Previously absent tendon reflexes returned at the biceps and triceps, and nerve conduction studies showed improvement in distal latencies and conduction velocities. more... http://www.neurotodayonline.com/pt/re/neurotoday/fulltext.00132985-200807030-00003.htm;jsessionid=L0pHmqGTTLC5m3LGQlppQ9W2SxxPR CssqpbDftyxfYnK0pdGQ0cv!218002192!181195629!8091!-1 Last edited by manouli; 07-08-2008 at 10:14 PM.

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07-07-2008, 09:17 PM	#1991
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,338	Monday, July 7, 2008 Stem Cell Research Headed to Ballots by Richard Piet Stem cell research in the state could be closer to getting the green light as of Monday. Proponents of the drive to permit stem cell research in Michigan think they have voters on their side. "We may have set a record," says Larry Owen. "We're going to file more than 560-thousand signatures of Michigan citizens." more.... http://wkzonews.blogspot.com/2008/07...o-ballots.html

07-08-2008, 09:07 AM	#1992
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,338	Novel high-throughput automated stem cell culture & screening system KINGSTON, England, July 8, 2008-A novel high-throughput automated stem cell culture and screening system is described in a new technical data sheet available from Velocity11 (Menlo Park, CA), an Agilent Technologies company. The technical data sheet describes how an automated platform was developed with a customer who wanted to use stem cells as the basis of their HTS assays and drug discovery programs, with the goal to increase their throughput and potentially find more promising lead compounds. To successfully automate these sensitive assays they required an automated system with a controlled environment which would provide the best conditions for cell growth. more... http://www.pharmalive.com/News/index...&categoryid=15

07-08-2008, 09:13 AM	#1993
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,338	July 08, 2008 06:30 AM Eastern Daylight Time International Stem Cell Corporation Announces Collaboration with Michigan State University to Study Parthenogenetic Stem Cells OCEANSIDE, Calif.--(BUSINESS WIRE)--International Stem Cell Corporation (OTCBB: ISCO) announced today a new collaboration with leading stem cell researcher Jose Cibelli at Michigan State University as part of ISCO’s ongoing strategy to work with scientific leaders across the world to expand the scientific data relating to parthenogenetic stem cells. Professor Cibelli will study gene expression in several human parthenogenetic stem cell lines and compare the results with fertilized embryonic stem cells. According to Professor Cibelli, “We have observed in mouse and monkey that imprinting in parthenogenetic cells changes as the cells are cultured. This in vitro phenomenon can be advantageous for parthenogenetic cells.” more... http://www.businesswire.com/portal/s...02&newsLang=en

07-08-2008, 09:49 PM	#1994
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,338	Can Stem Cells Combat Wrinkles? Posted on: Tuesday, 8 July 2008, 12:15 CDT Restore and renew. "Significantly reduces the loss of cells in the epidermis." "Regenerate cells and repair tissue." The newest skin creams beckon with an air of scientific gravitas, holding out the hope that now, at last, medicine has triumphed over the visible aging process. With tantalizing biological references and understated packaging, the products are among the first to capitalize on the public's insatiable appetite for stem-cell technology. "The goal of these products is to create a more youthful cell that would replenish elastin and collagen," says Dr. Kenneth Beer, a West Palm Beach, Fla., dermatologist. A clinical instructor at the University of Miami, he conducts clinical trials on skin-care products. And, of course, what better way to do that than to harness stem cells, those potential miracles of self-repair and curative power on which society is pinning so many medical hopes? But a word of caution before you plunk down $80 or $155 for these potions: They might be no better than existing anti-aging skin creams, the best of which spur the skin to work harder but still produce only modest effects. Adds Beer of the stem-cell-touting products' potential: "The notion that you could do that with a cream is a little bit ahead of itself. It's a great piece of marketing because there is so much interest in stem cells." That's not to say that stem cells couldn't ultimately improve skin, perhaps in the next decade or so, says Dr. Leslie Baumann, a dermatology professor and director of the University of Miami's Cosmetic Center - but that time has not arrived, she says. For now, consumers are being misled, she says. In fact, the creams don't even contain live stem cells - just the suggestion that they're comparable in some way to the much-heralded, but largely unharnessed, cellular powerhouses. The stem-cell skin cream frenzy began last year when a Salt Lake City company called Voss Laboratories released its product, Amatokin, at Bloomingdale's with the advertising slogan "Stem Cells: The future of skin rejuvenation." It cost $190 for a 30-milliliter tube - about 1 ounce. more... http://www.redorbit.com/news/health/...les/index.html

07-08-2008, 10:41 PM	#1996
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,338	Dr. breaks new ground by using stem cells on damaged hearts 08:08 PM CDT on Tuesday, July 8, 2008 Meg Farris / Eyewitness News Medical Reporter Some people with heart failure, who have no more treatment options, are surprised to find out that there may be one last hope in Covington. A local doctor is doing the only research of its kind with stem cells that could prove to be life saving for people with cardiovascular disease. Aaron Cathcart’s heart was so damaged from years of high blood pressure that some doctors said he would not survive any treatment or surgery. Video: Watch the Story "He said he had never seen any body with a heart as bad as mine that was still living," Aaron recalled one doctor saying. But Aaron’s daughter scoured the Internet and found one last hope for her father and surprisingly it was nearby – in Covington. Dr. Gabriel Lasala, an interventional cardiologist, harvested some of Aaron's stem cells from his bone marrow. The idea behind harvesting stem cells is that they can repair damaged tissue. more... http://www.wwltv.com/medical/stories....37dde8dd.html

07-09-2008, 08:39 PM	#1997
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,338	California Stem Cell Research Panel Opposes Bill Making it Help Patients by Steven Ertelt LifeNews.com Editor July 9, 2008 Sacramento, CA (LifeNews.com) -- The California panel created by Proposition 71 was supposed to benefit patients across the state by allowing scientists access to funds for research for cures. However, the committee funding by the initiative is opposing a bill in the state legislature to make it do just that. The California Institute for Regenerative Medicine has emailed its supporters a dire-sounding letter saying its existence is threatened by legislative efforts to keep it accountable. "We need you to take a few minutes to help save the California Institute for Regenerative Medicine and embryonic stem cell research in California. This is under siege right now in the state legislature," the group claims. CIRM opposes Senate Bill 1565, which would require it to include in its intellectual property standards a requirement that each grantee and licensee submit for CIRM's approval a plan that will afford uninsured Californians access to any drug that is, in whole or in part, the result of research funded by the CIRM. more... http://www.lifenews.com/bio2505.html

07-09-2008, 08:45 PM	#1998
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,338	New Technique Harvests Stem Cells at Earlier Stage Research shows future production of new lines may be done without destroying embryo Posted July 9, 2008 WEDNESDAY, July 9 (HealthDay News) -- Scientists say they have finally succeeded in developing human embryonic stem cells earlier in the development stage of a blastomere, or a 4-cell stage embryo, so the whole embryo is not destroyed. The development, expected to be presented Wednesday at the European Society of Human Reproduction & Embryology annual conference in Barcelona, may make stem cell research easier to conduct by not raising as many ethical concerns, the researchers added. more.... http://health.usnews.com/articles/he...ier-stage.html

07-09-2008, 08:59 PM	#1999
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,338	Bio-Matrix Scientific Group, Inc. Announces Negotiations with Four Companies for Storage of Peripheral Blood Related Stem Cells 7/9/2008 @ 6:58 AM Bio-Matrix Scientific Group, Inc. (OTCBB:BMSN) announced today that it is currently in negations with four companies to provide storage for peripheral blood related stem cell specimens. It is anticipated that, in the event that negotiations are successful, an excess of 15,000 specimens may be stored by the Company in the first year generating average revenue of $650 per specimen. more... http://www.freshnews.com/news/biotec...le_44344.html?

07-09-2008, 09:06 PM	#2000
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,338	Spraying Stem Cells Heals Skin Faster By medinews.com staff writers Posted on 09 July 2008 A futuristic spray gun, similar in concept to an inkjet printer, sprays new infused skin onto a wound, essentially speeding up the healing process to a matter of hours. Researchers at Wake Forest University Baptist Medical Center (Winston-Salem, NC, USA), the McGowan Institute for Regenerative Medicine (MIRM, Pittsburgh, PA, USA) and other institutions forming part of the U.S. Armed Forces Institute for Regenerative Medicine (AFIRM) are developing a handheld spray gun that spurts a thin layer of keratinocytes (immature skin cells) over deep skin wounds. The keratinocytes, harvested from the patient, are stored in cartridges along with a mix of growth factors and special nutrients; after being sprayed on the wound, they then “print” layers of skin tissue directly onto the wounds. The other essential part of the process is an innovative wound dressing; enmeshed in what looks like a traditional dressing is in reality a bioreactor; tubes extend from each end of the dressing, one doing the work of an artery, the other of a vein. When connected to an artificial vascular system the bioreactor bandage distributes glucose, sugar, amino acids, antibiotics, and electrolytes to the treated area. It cleans the wound, provides nutrition, and better supports the stem cells in the wound until they start to grow and regenerate new skin for the patient. more... http://www.medinews.com/GMEDTS32olcg...ritical%20Care