Stem Cell Articles - Page 193

manouli · 06-23-2008, 09:44 AM

Beike Biotech opens stem cell storage facility in China

Monday, June 23, 2008 11:00 IST
Taizhou, Jiangsu Province

Shenzhen Beike Biotechnology Co., Ltd., a worldwide leader in providing safe and effective stem cell applications for medical treatment, has commenced outfitting its 21,500 square foot comprehensive medical stem cell storage and processing facility in eastern China.

Jiangsu Stem Cell Storage Facility will be one of the most highly developed of its kind anywhere in the world, with advanced technology and safe conditions to properly freeze, store, and process a broad range of human stem cell samples for clinical application. The stem cell storage facility will initially provide stem cell banking for human umbilical cord blood stem cells, placenta stem cells, amniotic membrane stem cells, bone marrow stem cells, and later will also be able to house induced pluripotent stem cells (iPS).

more....

http://www.pharmabiz.com/article/det...815&sectionid=

manouli · 06-23-2008, 06:49 PM

Mesenchymal Stem Cells: A Therapeutic Treatment For Severe And Acute
Article Date: 23 Jun 2008 - 13:00 PDT

A phase II multicenter study performed within the European Group for Blood and Marrow Transplantation (EBMT) Mesenchymal Stem Cell Expansion Consortium, shows that mesenchymal stem cells provide a therapeutic potential for the treatment of acute steroid-refractory GvHD (graft-versus-host disease).

Allogeneic stem-cell transplantation is the treatment of choice for many malignant and non-malignant disorders. Severe graft-versus-host disease (GvHD) is a life-threatening complication which could arise following this treatment. Especially if patients with GvHD do not respond to steroids, therapeutic options are limited and the success uncertain. This publication in one of the leading scientific journals opens new exciting possibilities for patients with GvHD.

The study was launched to assess whether mesenchymal stem cells could reduce the risk of GvHD after stem cell transplantation.

Between October 2001 and January 2007, 55 patients were treated. From this, 30 patients had a complete response and nine showed improvement. No patients had side effects during or immediately after infusions of mesenchymal stem cells. This response was not related to donor HLA-match. Three patients had recurrent malignant disease and one developed de-novo acute myeloid leukaemia of recipient origin.

This phase II study shows that the infusion of mesenchymal stem cells expanded in vitro, irrespective of donor, might be an effective therapy for patients with steroid-resistant, acute GvHD. Most interestingly, there was no difference in the response rates or side effects between patients receiving mesenchymal stem cells from third-party mismatched donors compared with those patients receiving cells from HLA-identical siblings or from haploidentical family members.

more....

http://www.medicalnewstoday.com/articles/112419.php

manouli · 06-23-2008, 06:54 PM

JGH doctors excited by new stem cell therapy
By Janice Arnold

A “big step forward” in the potential treatment of incurable disease by genetically modifying the patient’s own stem cells was announced by doctors at the Jewish General Hospital (JGH) last week.

Hematologist Dr. Jacques Galipeau and cardiologist Dr. David Langleben called a press conference to report what Langleben termed “absolutely fabulous” results after the experimental treatment on two Quebec volunteers with the rare, progressive lung disease, pulmonary hypertension.

The clinical study, sponsored by the Canadian Stem Cell Network and involving St. Michael’s Hospital in Toronto, was described as unique in the world, both for its manipulation of the stem cells and for the large number of cells administered to the patients, with no ill effects.

The primary focus of the trial at this stage was to establish the procedure’s safety, said Langleben, director of the JGH’s Centre for Pulmonary Vascular Disease. The positive effect that was observed in both patients’ health was a bonus that astonished the scientific team.

more....

http://www.juf.org/news/local.aspx?id=34186&source=home

manouli · 06-24-2008, 04:30 PM

Scientists repair brain using GM embryo cells

By Roger Highfield, Science Editor
Last Updated: 5:01pm BST 24/06/2008

Brain repair using GM embryo cells could offer novel treatments for stroke, Alzheimer's, Parkinson's and other neurological conditions, after encouraging preliminary tests.

Scientists use 'biological alchemy' to convert one cell type into another
Biotech: crunch time for UK biotech
Scientists uncover secret of eternal youth
Scientists at the Burnham Institute for Medical Research in La Jolla, California, have, for the first time, genetically programmed embryonic stem cells, which have the potential to turn into any type, to become nerve cells when transplanted into the brain, according to a study in The Journal of Neuroscience.

more...

http://www.telegraph.co.uk/earth/mai...cibrain124.xml

manouli · 06-24-2008, 04:33 PM

Comprehensive Stem Cell Storage And Processing Facility Opening In China
June 24, 2008

Taizhou, Jiangsu Province, China - Shenzhen Beike Biotechnology Co., Ltd., a worldwide leader in providing safe and effective stem cell applications for medical treatment, has commenced outfitting its 21,500 square foot comprehensive medical stem cell storage and processing facility in eastern China. When fully completed, the Jiangsu Stem Cell Storage Facility will be one of the most highly developed of its kind anywhere in the world, with advanced technology and safe conditions to properly freeze, store, and process a broad range of human stem cell samples for clinical application. The Stem Cell Storage Facility will initially provide stem cell banking for human umbilical cord blood stem cells, placenta stem cells, amniotic membrane stem cells, bone marrow stem cells, and later will also be able to house induced pluripotent stem cells (iPS). Considered the future for stem cell treatments, iPS cells are derived from cell reprogramming technologies and are a non-controversial potential alternative to embryonic stem cells. Like umbilical cord blood stem cells, iPS cells can be preserved for later use in fighting a range of disorders.

more....

http://www.bioresearchonline.com/art...-Facility-0001

manouli · 06-24-2008, 05:02 PM

Stem Cells Could Replace Plastic Surgery
By Maggie Koerth-Baker, Special to LiveScience

posted: 2008-06-24 6:55 a.m. ET

Silicone breast implants and botox could one day be things of the past thanks to promising new techniques that would allow doctors to work plastic surgery miracles using only a patient's own stem cells.

Traditionally, plastic and reconstructive surgery has relied heavily on fillers. Bags full of saline or silicone are used to plump up breasts. Chunks of fat are taken from one area of the body and grafted into another. These techniques, which like other body enhancement procedures have soared in popularity in recent years, can work successfully but they also have drawbacks.

Dr. J. Peter Rubin, assistant professor of plastic and reconstructive surgery at the University of Pittsburgh School of Medicine, said using fillers requires invasive surgery and the results may not look ideally natural. In the case of fat grafts, they also might not last as long as a patient would like, as fat transferred whole to a new part of the body has a tendency to break down as time goes on.

Replacing these fillers with stem cells could solve the problems.

Stem cell magic

more...

http://www.livescience.com/health/08...tem-cells.html

manouli · 06-24-2008, 08:42 PM

Nerve Cells Derived From Stem Cells And Transplanted Into Mice May Lead To Improved Brain Treatments

ScienceDaily (June 24, 2008) — Scientists at the Burnham Institute for Medical Research have, for the first time, genetically programmed embryonic stem (ES) cells to become nerve cells when transplanted into the brain, according to a new study published in The Journal of Neuroscience

The research, an important step toward developing new treatments for stroke, Alzheimer's, Parkinson's and other neurological conditions showed that mice afflicted by stroke showed tangible therapeutic improvement following transplantation of these cells. None of the mice formed tumors, which had been a major setback in prior attempts at stem cell transplantation.

more....

http://www.sciencedaily.com/releases...0624174843.htm

manouli · 06-24-2008, 08:49 PM

Large-Scale European Project Initiated for Imaging in Stem Cell Therapy Research

By biotechdaily.com staff writers
Posted on 24 June 2008

An international research group from 10 countries is planning to develop imaging technologies and methods in the field of cell therapy.

The European Institute for Biomedical Imaging Research (EIBIR; Vienna, Austria) has taken over the coordination of a European large-scale research project. The project, entitled ENCITE (European Network for Cell Imaging and Tracking Expertise), began on June 1, 2008.

more...

http://www.medinews.com/GMEDTS32olcg....111.28711.0.0

manouli · 06-25-2008, 11:11 AM

June 25, 2008 09:30 AM Eastern Daylight Time

International Stem Cell Corporation Signs Agreement with BioTime, Inc., and Embryome Sciences, Inc., to Provide Unique Human Stem Cell Lines for Research Use

OCEANSIDE, Calif.--(BUSINESS WIRE)--International Stem Cell Corporation (OTCBB:ISCO), through its wholly owned subsidiary Lifeline Cell Technology (Lifeline), has signed a manufacturing and distribution agreement with BioTime, Inc., (OTCBB:BTIM) (Alameda, CA) and BioTime’s wholly owned subsidiary Embryome Sciences, Inc., to jointly produce and distribute hundreds of new standardized human and animal stem cell lines, along with corresponding data and reagents. The mutual goal is to provide the “picks and shovels” for scientists mining the stem cell field for therapeutics in the emerging fields of regenerative medicine and pharmaceutical drug discovery.

These unique stem cell lines (called “progenitor” cell lines) possess the potential to expand and become specific types of tissues and cells such as heart, liver, skeletal muscle, bone, retinal, nerve, pancreas and others – all necessary to study various human diseases where regenerative medicine shows great promise.

more...

http://www.businesswire.com/portal/s...07&newsLang=en

manouli · 06-25-2008, 11:19 AM

HepaLife(TM) Develops New Liver Stem Cell Lines for Bioartificial Liver Device; Data Presented at Scientific Conferences
06.25.08, 9:19 AM ET

HepaLife Technologies, Inc. (OTCBB: HPLF) (FWB: HL1) (WKN: 500625), today announced the development of two new derivative cell lines from the Company's patented PICM-19 liver stem cells for use in HepaLife's first-of-its-kind bioartificial liver device currently under development for the treatment of human liver failure.

"These two cell lines have unique and special functionalities, and make it possible to more closely model the function of the natural liver in our device than before," explained Mr. Frank Menzler, President and CEO of HepaLife Technologies, Inc. "These cell lines further enable us to progress more rapidly in our efforts to scale-up the manufacturing into larger-scale production of our cells, an important requirement for using the cells inside an artificial liver device."

Researchers presented initial data on the Company's new cell lines at the 6th Annual Meeting of International Society for Stem Cell Research in Philadelphia, PA and the 54th American Society of Internal Artificial Organs annual conference in San Francisco, CA, earlier this month.

The two immortalized unipotent porcine liver stem cell lines are: the 'PICM-19H', capable of differentiating exclusively into 'hepatocytes' or liver cells with the ability to express hepatocyte or liver-cell function; and, the 'PICM-19B,' capable of differentiating exclusively into bile duct cells with the ability to express bile duct cell function.

more...

http://www.forbes.com/businesswire/f...5005317r1.html

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06-23-2008, 09:44 AM	#1921
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,335	Beike Biotech opens stem cell storage facility in China Monday, June 23, 2008 11:00 IST Taizhou, Jiangsu Province Shenzhen Beike Biotechnology Co., Ltd., a worldwide leader in providing safe and effective stem cell applications for medical treatment, has commenced outfitting its 21,500 square foot comprehensive medical stem cell storage and processing facility in eastern China. Jiangsu Stem Cell Storage Facility will be one of the most highly developed of its kind anywhere in the world, with advanced technology and safe conditions to properly freeze, store, and process a broad range of human stem cell samples for clinical application. The stem cell storage facility will initially provide stem cell banking for human umbilical cord blood stem cells, placenta stem cells, amniotic membrane stem cells, bone marrow stem cells, and later will also be able to house induced pluripotent stem cells (iPS). more.... http://www.pharmabiz.com/article/det...815&sectionid=

06-23-2008, 06:49 PM	#1922
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,335	Mesenchymal Stem Cells: A Therapeutic Treatment For Severe And Acute Article Date: 23 Jun 2008 - 13:00 PDT A phase II multicenter study performed within the European Group for Blood and Marrow Transplantation (EBMT) Mesenchymal Stem Cell Expansion Consortium, shows that mesenchymal stem cells provide a therapeutic potential for the treatment of acute steroid-refractory GvHD (graft-versus-host disease). Allogeneic stem-cell transplantation is the treatment of choice for many malignant and non-malignant disorders. Severe graft-versus-host disease (GvHD) is a life-threatening complication which could arise following this treatment. Especially if patients with GvHD do not respond to steroids, therapeutic options are limited and the success uncertain. This publication in one of the leading scientific journals opens new exciting possibilities for patients with GvHD. The study was launched to assess whether mesenchymal stem cells could reduce the risk of GvHD after stem cell transplantation. Between October 2001 and January 2007, 55 patients were treated. From this, 30 patients had a complete response and nine showed improvement. No patients had side effects during or immediately after infusions of mesenchymal stem cells. This response was not related to donor HLA-match. Three patients had recurrent malignant disease and one developed de-novo acute myeloid leukaemia of recipient origin. This phase II study shows that the infusion of mesenchymal stem cells expanded in vitro, irrespective of donor, might be an effective therapy for patients with steroid-resistant, acute GvHD. Most interestingly, there was no difference in the response rates or side effects between patients receiving mesenchymal stem cells from third-party mismatched donors compared with those patients receiving cells from HLA-identical siblings or from haploidentical family members. more.... http://www.medicalnewstoday.com/articles/112419.php

06-23-2008, 06:54 PM	#1923
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,335	JGH doctors excited by new stem cell therapy By Janice Arnold A “big step forward” in the potential treatment of incurable disease by genetically modifying the patient’s own stem cells was announced by doctors at the Jewish General Hospital (JGH) last week. Hematologist Dr. Jacques Galipeau and cardiologist Dr. David Langleben called a press conference to report what Langleben termed “absolutely fabulous” results after the experimental treatment on two Quebec volunteers with the rare, progressive lung disease, pulmonary hypertension. The clinical study, sponsored by the Canadian Stem Cell Network and involving St. Michael’s Hospital in Toronto, was described as unique in the world, both for its manipulation of the stem cells and for the large number of cells administered to the patients, with no ill effects. The primary focus of the trial at this stage was to establish the procedure’s safety, said Langleben, director of the JGH’s Centre for Pulmonary Vascular Disease. The positive effect that was observed in both patients’ health was a bonus that astonished the scientific team. more.... http://www.juf.org/news/local.aspx?id=34186&source=home

06-24-2008, 04:30 PM	#1924
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,335	Scientists repair brain using GM embryo cells By Roger Highfield, Science Editor Last Updated: 5:01pm BST 24/06/2008 Brain repair using GM embryo cells could offer novel treatments for stroke, Alzheimer's, Parkinson's and other neurological conditions, after encouraging preliminary tests. Scientists use 'biological alchemy' to convert one cell type into another Biotech: crunch time for UK biotech Scientists uncover secret of eternal youth Scientists at the Burnham Institute for Medical Research in La Jolla, California, have, for the first time, genetically programmed embryonic stem cells, which have the potential to turn into any type, to become nerve cells when transplanted into the brain, according to a study in The Journal of Neuroscience. more... http://www.telegraph.co.uk/earth/mai...cibrain124.xml

06-24-2008, 04:33 PM	#1925
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,335	Comprehensive Stem Cell Storage And Processing Facility Opening In China June 24, 2008 Taizhou, Jiangsu Province, China - Shenzhen Beike Biotechnology Co., Ltd., a worldwide leader in providing safe and effective stem cell applications for medical treatment, has commenced outfitting its 21,500 square foot comprehensive medical stem cell storage and processing facility in eastern China. When fully completed, the Jiangsu Stem Cell Storage Facility will be one of the most highly developed of its kind anywhere in the world, with advanced technology and safe conditions to properly freeze, store, and process a broad range of human stem cell samples for clinical application. The Stem Cell Storage Facility will initially provide stem cell banking for human umbilical cord blood stem cells, placenta stem cells, amniotic membrane stem cells, bone marrow stem cells, and later will also be able to house induced pluripotent stem cells (iPS). Considered the future for stem cell treatments, iPS cells are derived from cell reprogramming technologies and are a non-controversial potential alternative to embryonic stem cells. Like umbilical cord blood stem cells, iPS cells can be preserved for later use in fighting a range of disorders. more.... http://www.bioresearchonline.com/art...-Facility-0001

06-24-2008, 05:02 PM	#1926
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,335	Stem Cells Could Replace Plastic Surgery By Maggie Koerth-Baker, Special to LiveScience posted: 2008-06-24 6:55 a.m. ET Silicone breast implants and botox could one day be things of the past thanks to promising new techniques that would allow doctors to work plastic surgery miracles using only a patient's own stem cells. Traditionally, plastic and reconstructive surgery has relied heavily on fillers. Bags full of saline or silicone are used to plump up breasts. Chunks of fat are taken from one area of the body and grafted into another. These techniques, which like other body enhancement procedures have soared in popularity in recent years, can work successfully but they also have drawbacks. Dr. J. Peter Rubin, assistant professor of plastic and reconstructive surgery at the University of Pittsburgh School of Medicine, said using fillers requires invasive surgery and the results may not look ideally natural. In the case of fat grafts, they also might not last as long as a patient would like, as fat transferred whole to a new part of the body has a tendency to break down as time goes on. Replacing these fillers with stem cells could solve the problems. Stem cell magic more... http://www.livescience.com/health/08...tem-cells.html

06-24-2008, 08:42 PM	#1927
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,335	Nerve Cells Derived From Stem Cells And Transplanted Into Mice May Lead To Improved Brain Treatments ScienceDaily (June 24, 2008) — Scientists at the Burnham Institute for Medical Research have, for the first time, genetically programmed embryonic stem (ES) cells to become nerve cells when transplanted into the brain, according to a new study published in The Journal of Neuroscience The research, an important step toward developing new treatments for stroke, Alzheimer's, Parkinson's and other neurological conditions showed that mice afflicted by stroke showed tangible therapeutic improvement following transplantation of these cells. None of the mice formed tumors, which had been a major setback in prior attempts at stem cell transplantation. more.... http://www.sciencedaily.com/releases...0624174843.htm

06-24-2008, 08:49 PM	#1928
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,335	Large-Scale European Project Initiated for Imaging in Stem Cell Therapy Research By biotechdaily.com staff writers Posted on 24 June 2008 An international research group from 10 countries is planning to develop imaging technologies and methods in the field of cell therapy. The European Institute for Biomedical Imaging Research (EIBIR; Vienna, Austria) has taken over the coordination of a European large-scale research project. The project, entitled ENCITE (European Network for Cell Imaging and Tracking Expertise), began on June 1, 2008. more... http://www.medinews.com/GMEDTS32olcg....111.28711.0.0

06-25-2008, 11:11 AM	#1929
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,335	June 25, 2008 09:30 AM Eastern Daylight Time International Stem Cell Corporation Signs Agreement with BioTime, Inc., and Embryome Sciences, Inc., to Provide Unique Human Stem Cell Lines for Research Use OCEANSIDE, Calif.--(BUSINESS WIRE)--International Stem Cell Corporation (OTCBB:ISCO), through its wholly owned subsidiary Lifeline Cell Technology (Lifeline), has signed a manufacturing and distribution agreement with BioTime, Inc., (OTCBB:BTIM) (Alameda, CA) and BioTime’s wholly owned subsidiary Embryome Sciences, Inc., to jointly produce and distribute hundreds of new standardized human and animal stem cell lines, along with corresponding data and reagents. The mutual goal is to provide the “picks and shovels” for scientists mining the stem cell field for therapeutics in the emerging fields of regenerative medicine and pharmaceutical drug discovery. These unique stem cell lines (called “progenitor” cell lines) possess the potential to expand and become specific types of tissues and cells such as heart, liver, skeletal muscle, bone, retinal, nerve, pancreas and others – all necessary to study various human diseases where regenerative medicine shows great promise. more... http://www.businesswire.com/portal/s...07&newsLang=en

06-25-2008, 11:19 AM	#1930
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,335	HepaLife(TM) Develops New Liver Stem Cell Lines for Bioartificial Liver Device; Data Presented at Scientific Conferences 06.25.08, 9:19 AM ET HepaLife Technologies, Inc. (OTCBB: HPLF) (FWB: HL1) (WKN: 500625), today announced the development of two new derivative cell lines from the Company's patented PICM-19 liver stem cells for use in HepaLife's first-of-its-kind bioartificial liver device currently under development for the treatment of human liver failure. "These two cell lines have unique and special functionalities, and make it possible to more closely model the function of the natural liver in our device than before," explained Mr. Frank Menzler, President and CEO of HepaLife Technologies, Inc. "These cell lines further enable us to progress more rapidly in our efforts to scale-up the manufacturing into larger-scale production of our cells, an important requirement for using the cells inside an artificial liver device." Researchers presented initial data on the Company's new cell lines at the 6th Annual Meeting of International Society for Stem Cell Research in Philadelphia, PA and the 54th American Society of Internal Artificial Organs annual conference in San Francisco, CA, earlier this month. The two immortalized unipotent porcine liver stem cell lines are: the 'PICM-19H', capable of differentiating exclusively into 'hepatocytes' or liver cells with the ability to express hepatocyte or liver-cell function; and, the 'PICM-19B,' capable of differentiating exclusively into bile duct cells with the ability to express bile duct cell function. more... http://www.forbes.com/businesswire/f...5005317r1.html