Stem Cell Articles - Page 192

manouli · 06-20-2008, 11:10 AM

Stem cell laboratories boost economy

Stem cell scientists have taken a step closer to developing pioneering new therapies with the opening of a £3m trio of laboratories at Durham University.
The laboratories will be used for investigations into the therapeutic potential of "adult" stem cells for medical issues such as wound healing and heart disease.

Margaret Fay, chief executive of One NorthEast, said: "The North East England Stem Cell Institute has a real opportunity to make an invaluable contribution to the region's economy, its future success and quality of life issues over the coming years."

more...

http://www.northumberlandgazette.co....omy.4208004.jp

manouli · 06-20-2008, 11:14 AM

Stem cells offer new hope

Lung therapy. Patient with rare disease taken off of transplant list
AARON DERFEL, The Gazette
Published: 8 hours ago

Ever since Lucie Moisan developed pulmonary hypertension more than a decade ago, she's often been short of breath. Unable to work, even simple household chores tired her out.

Yet last year, she underwent an experimental procedure that holds the promise of reversing her rare disease. Doctors at the Jewish General Hospital harvested stem cells from her blood, genetically re-engineered them in the lab and then infused them into her lungs.

The re-engineered cells entered the tiny arteries in her lungs, and helped repair tissue. Even though the treatment lasted only three days, Moisan said she felt a difference almost immediately

more...

http://www.canada.com/montrealgazett...a-1fa66d285ce0

manouli · 06-20-2008, 11:18 AM

Predicting The Risk Of A Common Fungal Infection After Stem Cell Transplantation

ScienceDaily (June 19, 2008) — In silico genetic analysis in mice has led to the discovery of a gene affecting susceptibility to a severe fungal infection in transplant recipients.I nvestigators from Duke University Medical Center, the National Institute of Environmental Health Sciences, Roche Palo Alto, the Fred Hutchinson Cancer Research Center, and the National Jewish Medical and Research Center have found that genetic variation within the plasminogen gene in mice and men affects susceptibility to a severe and life-threatening fungal infection.

Invasive infection with Aspergillus fumigatus is a common and life-threatening infection among severely immunocompromised individuals. Despite aggressive surveillance and prophylaxis, its incidence in hematopoietic stem cell transplant recipients hovers around 10%, and the three-month mortality rate is approaching 30%.

more...

http://www.sciencedaily.com/releases...0619203251.htm

manouli · 06-21-2008, 08:29 PM

O'Keefe Receives Gruber Neuroscience Prize For Discovery Of Place Cells And Their Role In Cognition

Article Date: 21 Jun 2008 - 10:00 PDT

John O'Keefe, PhD, Professor of Cognitive Neuroscience at University College London, is the recipient of the 2008 Neuroscience Prize of the Peter and Patricia Gruber Foundation for "his pioneering work concerning the neural basis of complex cognitive functions in freely moving animals."

O'Keefe will receive the Gruber Neuroscience Prize on November 16, 2008, during the annual meeting of the Society for Neuroscience in Washington, D.C. The prize consists of a gold medal and $500,000. O'Keefe will deliver the Peter and Patricia Gruber Lecture entitled "The Role of Theta Oscillations in Spatial Processing in the Hippocampal Formation" immediately following the award ceremony.

"The discovery of 'place cells' and their abstract mnemonic properties was a vital milestone in the development of the field of cognitive neuroscience," reads the Gruber citation. "John O'Keefe's work inspired the research of many others in the field of memory and served as an example of the application of physiological and computational approaches to the understanding of behavior."

"John O´Keefe´s astounding discovery explains how the brain makes us find the way from point A to B along a tortuous and complex path. We then need to remember a sequence of different places to pass - all in appropriate order. Each "place cell" serves as a sign-post that tells us how far we have reached along the path" says Sten Grillner, MD, noted neuroscientist at Sweden's Karolinska Institute and chair of Gruber's Neuroscience Selection Advisory Board.

"The ability to remember the path to any important location, spatial navigation, is an indispensable property of the nervous system of practically all animals, without which there would be chaos. It also tells us about key aspects of learning which may have critical importance in understanding human disorders such as memory loss," Grillner adds.

more....

http://www.medicalnewstoday.com/articles/112029.php

manouli · 06-21-2008, 08:58 PM

Let doctors work to cure disease
June 21, 2008

I've closely followed the stem cell issue because I believe my granddaughter's rheumatoid arthritis could one day be cured by this promising field of medicine.

Isn't it ironic that a minority of individuals who seek to block the very research that is supported by the National Institutes of Health, National Academy of Sciences and more than 90 Nobel Prize winners would have the arrogance to proclaim "science is on our side"? (News-Leader June 11 story)

Opponents of stem cell research, with their anti-cures agenda, find themselves contrary to all mainstream science and medical groups, as well as myriad patient advocacy organizations, which support pursuing all forms of stem cell research.

more...

http://www.news-leader.com/apps/pbcs.../1006/OPINIONS

manouli · 06-21-2008, 09:02 PM

Stem Cells Correct Defect In Child’s Fatal Skin Disease

ScienceDaily (June 20, 2008) — Researchers and clinicians have paved the way toward a cure for a young boy’s genetic and fatal skin disease, recessive dystrophic epidermolysis bullosa (RDEB), by using a cord blood and bone marrow transplant. Nate Liao, 25 months old from Clarksburg, N.J., underwent the experimental therapy in October 2007, as the result of a research and clinical collaboration between researchers at Columbia University Medical Center in New York and Thomas Jefferson University in Philadelphia and physicians at the University of Minnesota and University of Minnesota Children’s Hospital, Fairview.

Children with RDEB have skin that is exquisitely delicate because of a genetic defect that results in the absence of a critical protein called collagen type VII, which anchors the skin and lining of the gastrointestinal (GI) system to the body. Without collagen type VII, the skin of people with RDEB is extraordinarily fragile; tearing and blistering occur with minimal friction.

more...

http://www.sciencedaily.com/releases...0620213845.htm

manouli · 06-22-2008, 05:47 PM

New source of heart stem cells found: study
4 hours ago

PARIS (AFP) — Researchers in the United States have discovered a new group of stem cells that can give rise to heart muscle cells, known as cardiomyocytes, according to a study published Sunday.

The stem cells are located in the outermost layer of the heart and could one day play a critical role in regenerating injured heart tissue, the researchers say.

"In heart failure, you lose cardiomyocytes, so the only way to reverse heart failure is to make more of these cells," said William Pu, the study's lead researcher and a pediatric cardiologist at Children's Hospital in Boston, Massachusetts.

The new findings come on the heels of two earlier breakthroughs.

In 2006 scientists identified another cardiac stem cell -- marked by the expression of a gene called Nkx2-5 -- with the potential to become either heart muscle or cells lining blood vessels in the organ's left-sided chambers.

more...

http://afp.google.com/article/ALeqM5...Pgg4s1QUrGsVaA

manouli · 06-22-2008, 05:50 PM

‘Stem Cell Symphony’ nicely blends science, mystery
Sunday, June 22, 2008

By Jack Rightmyer

For more than a decade, Ricki Lewis has been writing science research articles and science textbooks. She published one of the first popular articles on human embryonic stem cells in 1997, but it was her own work as a hospice volunteer that gave her the idea to write her first book of fiction, “Stem Cell Symphony.”

The story follows Kelsey Raye, a geneticist who becomes tired of working with flies that have legs growing out of their heads, and decides to become a writer for Bio Tech USA, a science research magazine.

more...

http://www.dailygazette.com/news/200...ience-mystery/

manouli · 06-22-2008, 05:56 PM

Stem Cell Research Boost ; University Gets Pounds 3m Facilities
Posted on: Saturday, 21 June 2008, 18:00 CDT

By Neil McKay

STEM cell scientists yesterday took a step closer to developing pioneering new therapies with the opening of a pounds 3m trio of laboratories at Durham University.

The laboratories will be used for investigations into the therapeutic potential of 'adult' stem cells for medical issues such as wound healing and heart disease.

Durham University is a key partner in the North East England Stem Cell Institute (NESCI), and employs more than 50 stem cell researchers, including 12 senior academics.

The new laboratories, based on the University's Science Site on South Road, Durham, have been funded by One North East and the Government's Science Research Investment Fund.

Durham stem cell scientists are currently working on projects which include using stem cells to generate artificial blood vessels for use in heart transplantation and identifying how stem cells age to obtain knowledge which could be used in drug development.

more...

http://www.redorbit.com/news/health/...ource=r_health

manouli · 06-23-2008, 09:40 AM

Neurological Disorders: A Focus On Cord Blood Stem Cells As A Potential Treatment Option

Main Category: Neurology / Neuroscience
Also Included In: Stem Cell Research
Article Date: 23 Jun 2008 - 2:00 PDT

Today there are more than 600 known disorders and conditions that affect the nervous system and for many of them treatment options are extremely limited. In addition to the physical and mental toll these conditions take on patients, their families and caregivers, they also have an enormous economic impact, resulting in hundreds of billions of dollars annually in medical expenses and lost productivity.(1)

Scientists are pursuing research to gain a better understanding of the human nervous system in order to find new breakthroughs. Stem cell therapy is one therapeutic option that is showing great promise. Due to the complexities involved in harvesting human neural cells, easily-accessible, alternative stem cells - like those found in umbilical cord blood - are being researched as potential sources for cellular therapies to treat neurological diseases.

more....

http://www.medicalnewstoday.com/articles/112363.php

06-22-2008, 05:56 PM	#1919
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Stem Cell Research Boost ; University Gets Pounds 3m Facilities Posted on: Saturday, 21 June 2008, 18:00 CDT By Neil McKay STEM cell scientists yesterday took a step closer to developing pioneering new therapies with the opening of a pounds 3m trio of laboratories at Durham University. The laboratories will be used for investigations into the therapeutic potential of 'adult' stem cells for medical issues such as wound healing and heart disease. Durham University is a key partner in the North East England Stem Cell Institute (NESCI), and employs more than 50 stem cell researchers, including 12 senior academics. The new laboratories, based on the University's Science Site on South Road, Durham, have been funded by One North East and the Government's Science Research Investment Fund. Durham stem cell scientists are currently working on projects which include using stem cells to generate artificial blood vessels for use in heart transplantation and identifying how stem cells age to obtain knowledge which could be used in drug development. more... http://www.redorbit.com/news/health/...ource=r_health Last edited by manouli; 06-22-2008 at 06:03 PM.

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06-20-2008, 11:10 AM	#1911
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Stem cell laboratories boost economy Stem cell scientists have taken a step closer to developing pioneering new therapies with the opening of a £3m trio of laboratories at Durham University. The laboratories will be used for investigations into the therapeutic potential of "adult" stem cells for medical issues such as wound healing and heart disease. Margaret Fay, chief executive of One NorthEast, said: "The North East England Stem Cell Institute has a real opportunity to make an invaluable contribution to the region's economy, its future success and quality of life issues over the coming years." more... http://www.northumberlandgazette.co....omy.4208004.jp

06-20-2008, 11:14 AM	#1912
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Stem cells offer new hope Lung therapy. Patient with rare disease taken off of transplant list AARON DERFEL, The Gazette Published: 8 hours ago Ever since Lucie Moisan developed pulmonary hypertension more than a decade ago, she's often been short of breath. Unable to work, even simple household chores tired her out. Yet last year, she underwent an experimental procedure that holds the promise of reversing her rare disease. Doctors at the Jewish General Hospital harvested stem cells from her blood, genetically re-engineered them in the lab and then infused them into her lungs. The re-engineered cells entered the tiny arteries in her lungs, and helped repair tissue. Even though the treatment lasted only three days, Moisan said she felt a difference almost immediately more... http://www.canada.com/montrealgazett...a-1fa66d285ce0

06-20-2008, 11:18 AM	#1913
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Predicting The Risk Of A Common Fungal Infection After Stem Cell Transplantation ScienceDaily (June 19, 2008) — In silico genetic analysis in mice has led to the discovery of a gene affecting susceptibility to a severe fungal infection in transplant recipients.I nvestigators from Duke University Medical Center, the National Institute of Environmental Health Sciences, Roche Palo Alto, the Fred Hutchinson Cancer Research Center, and the National Jewish Medical and Research Center have found that genetic variation within the plasminogen gene in mice and men affects susceptibility to a severe and life-threatening fungal infection. Invasive infection with Aspergillus fumigatus is a common and life-threatening infection among severely immunocompromised individuals. Despite aggressive surveillance and prophylaxis, its incidence in hematopoietic stem cell transplant recipients hovers around 10%, and the three-month mortality rate is approaching 30%. more... http://www.sciencedaily.com/releases...0619203251.htm

06-21-2008, 08:29 PM	#1914
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	O'Keefe Receives Gruber Neuroscience Prize For Discovery Of Place Cells And Their Role In Cognition Article Date: 21 Jun 2008 - 10:00 PDT John O'Keefe, PhD, Professor of Cognitive Neuroscience at University College London, is the recipient of the 2008 Neuroscience Prize of the Peter and Patricia Gruber Foundation for "his pioneering work concerning the neural basis of complex cognitive functions in freely moving animals." O'Keefe will receive the Gruber Neuroscience Prize on November 16, 2008, during the annual meeting of the Society for Neuroscience in Washington, D.C. The prize consists of a gold medal and $500,000. O'Keefe will deliver the Peter and Patricia Gruber Lecture entitled "The Role of Theta Oscillations in Spatial Processing in the Hippocampal Formation" immediately following the award ceremony. "The discovery of 'place cells' and their abstract mnemonic properties was a vital milestone in the development of the field of cognitive neuroscience," reads the Gruber citation. "John O'Keefe's work inspired the research of many others in the field of memory and served as an example of the application of physiological and computational approaches to the understanding of behavior." "John O´Keefe´s astounding discovery explains how the brain makes us find the way from point A to B along a tortuous and complex path. We then need to remember a sequence of different places to pass - all in appropriate order. Each "place cell" serves as a sign-post that tells us how far we have reached along the path" says Sten Grillner, MD, noted neuroscientist at Sweden's Karolinska Institute and chair of Gruber's Neuroscience Selection Advisory Board. "The ability to remember the path to any important location, spatial navigation, is an indispensable property of the nervous system of practically all animals, without which there would be chaos. It also tells us about key aspects of learning which may have critical importance in understanding human disorders such as memory loss," Grillner adds. more.... http://www.medicalnewstoday.com/articles/112029.php

06-21-2008, 08:58 PM	#1915
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Let doctors work to cure disease June 21, 2008 I've closely followed the stem cell issue because I believe my granddaughter's rheumatoid arthritis could one day be cured by this promising field of medicine. Isn't it ironic that a minority of individuals who seek to block the very research that is supported by the National Institutes of Health, National Academy of Sciences and more than 90 Nobel Prize winners would have the arrogance to proclaim "science is on our side"? (News-Leader June 11 story) Opponents of stem cell research, with their anti-cures agenda, find themselves contrary to all mainstream science and medical groups, as well as myriad patient advocacy organizations, which support pursuing all forms of stem cell research. more... http://www.news-leader.com/apps/pbcs.../1006/OPINIONS

06-21-2008, 09:02 PM	#1916
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Stem Cells Correct Defect In Child’s Fatal Skin Disease ScienceDaily (June 20, 2008) — Researchers and clinicians have paved the way toward a cure for a young boy’s genetic and fatal skin disease, recessive dystrophic epidermolysis bullosa (RDEB), by using a cord blood and bone marrow transplant. Nate Liao, 25 months old from Clarksburg, N.J., underwent the experimental therapy in October 2007, as the result of a research and clinical collaboration between researchers at Columbia University Medical Center in New York and Thomas Jefferson University in Philadelphia and physicians at the University of Minnesota and University of Minnesota Children’s Hospital, Fairview. Children with RDEB have skin that is exquisitely delicate because of a genetic defect that results in the absence of a critical protein called collagen type VII, which anchors the skin and lining of the gastrointestinal (GI) system to the body. Without collagen type VII, the skin of people with RDEB is extraordinarily fragile; tearing and blistering occur with minimal friction. more... http://www.sciencedaily.com/releases...0620213845.htm

06-22-2008, 05:47 PM	#1917
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	New source of heart stem cells found: study 4 hours ago PARIS (AFP) — Researchers in the United States have discovered a new group of stem cells that can give rise to heart muscle cells, known as cardiomyocytes, according to a study published Sunday. The stem cells are located in the outermost layer of the heart and could one day play a critical role in regenerating injured heart tissue, the researchers say. "In heart failure, you lose cardiomyocytes, so the only way to reverse heart failure is to make more of these cells," said William Pu, the study's lead researcher and a pediatric cardiologist at Children's Hospital in Boston, Massachusetts. The new findings come on the heels of two earlier breakthroughs. In 2006 scientists identified another cardiac stem cell -- marked by the expression of a gene called Nkx2-5 -- with the potential to become either heart muscle or cells lining blood vessels in the organ's left-sided chambers. more... http://afp.google.com/article/ALeqM5...Pgg4s1QUrGsVaA

06-22-2008, 05:50 PM	#1918
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	‘Stem Cell Symphony’ nicely blends science, mystery Sunday, June 22, 2008 By Jack Rightmyer For more than a decade, Ricki Lewis has been writing science research articles and science textbooks. She published one of the first popular articles on human embryonic stem cells in 1997, but it was her own work as a hospice volunteer that gave her the idea to write her first book of fiction, “Stem Cell Symphony.” The story follows Kelsey Raye, a geneticist who becomes tired of working with flies that have legs growing out of their heads, and decides to become a writer for Bio Tech USA, a science research magazine. more... http://www.dailygazette.com/news/200...ience-mystery/

06-23-2008, 09:40 AM	#1920
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,337	Neurological Disorders: A Focus On Cord Blood Stem Cells As A Potential Treatment Option Main Category: Neurology / Neuroscience Also Included In: Stem Cell Research Article Date: 23 Jun 2008 - 2:00 PDT Today there are more than 600 known disorders and conditions that affect the nervous system and for many of them treatment options are extremely limited. In addition to the physical and mental toll these conditions take on patients, their families and caregivers, they also have an enormous economic impact, resulting in hundreds of billions of dollars annually in medical expenses and lost productivity.(1) Scientists are pursuing research to gain a better understanding of the human nervous system in order to find new breakthroughs. Stem cell therapy is one therapeutic option that is showing great promise. Due to the complexities involved in harvesting human neural cells, easily-accessible, alternative stem cells - like those found in umbilical cord blood - are being researched as potential sources for cellular therapies to treat neurological diseases. more.... http://www.medicalnewstoday.com/articles/112363.php