Stem Cell Articles - Page 190

manouli · 06-16-2008, 09:32 AM

Old stem cells can regain youth: Study
16 Jun 2008, 1355 hrs IST,IANS

NEW YORK: Stem cells in an old tissue are still able to perform regenerative functions, provided they receive appropriate chemical signals, according to a new study.

Earlier studies have shown that when old tissue is placed in an environment of young blood, the stem cells behave as if they are young again.

A team of bio-engineers at California University, led by Irina Conboy, identified two key pathways that determine how well adult stem cells repair and replace damaged tissue.

more....

http://timesofindia.indiatimes.com/H...ow/3133555.cms

manouli · 06-16-2008, 09:41 AM

oh boy....

Saturday, June 14, 2008

Pro-Life Dem Lawmaker Blasts Embryonic Stem Cell Research Plan [Jack Fowler]

New York is set to spend $600 million in taxpayer dollars on stem cell research. A recently released draft plan drooling over the potential of embryonic cells to cure a variety of diseases has drawn this blast from Rev. Ruben Diaz, the state senate's sole pro-life Democrat:
June 13, 2008

Judy Doesschate, J.D.
Director of Board Operations
Wadsworth Center
New York State Department of Health
Empire State Plaza, Box 509
Albany, NY 12208-0509

Dear Ms. Doesschate:

This letter is to express my response to the Empire State Stem Cell Board’s strategic framework that will guide New York State’s $600 Million, 11-year investment in stem cell research.

The report expresses the intention that New York’s investment in stem cell research will hold the promise of revitalizing and strengthening New York’s biomedical research industry, saving lives, and improving health. This is a false hope. The Empire State Stem Cell Board’s draft report discusses a great potential that may come from embryonic stem cells. To date, there have been no known cures - nor the promise of any cure - from embryonic stem cells.

Research in the area of embryonic stem cells is the twenty-first century’s version of alchemy. Medical researchers in this area are pursuing the “gold rush” to create an organ replacement industry to stave off illness and disease. While the practice of alchemy only involved the use of base metals, embryonic stem cell research requires the sacrifice of precious living human fetuses as fodder for their experiments.

more...

http://corner.nationalreview.com/pos...AxOGE3NDkyM2I=

manouli · 06-16-2008, 12:10 PM

Treating Stress Urinary Incontinence With Stem Cells Reported From The Annual Meeting Of The American Urological Association

Article Date: 15 Jun 2008 - 3:00 PDT

ORLANDO, FL (UroToday.com) - Dr. Rodriguez discussed use of stem cells for treating SUI (Stress Urinary Incontinence). A stem cell is embryonic, adult, or engineered. Embryonic stem cells come from the blastocyst which is totipotent or pluripotent. These cells are immortal, identical clonal cells with long-term self renewal. Controversies include possible tumor formation, the difficulty maintaining cell cultures and ethical issues.

Embryonic stem cells can differentiate into ectoderm, mesoderm and endoderm. Adult stem cells include hematopoetic stem cells, such as derived from bone marrow. This requires a bone marrow harvest, with low yield and difficulty to expand clones.

A variety of other tissues have been studied such as muscle or fat. This avoids ethical issues and it is easier to expand clones. However they are not immortal, identical, or totipotent and have no specific markers for identification.

more...

http://www.medicalnewstoday.com/articles/111309.php

manouli · 06-16-2008, 05:39 PM

this is good news.

Adult Stem Cells Aid Fracture Healing; Study Lays Groundwork for Potential Treatments

Newswise — In an approach that could become a new treatment for the 10 to 20 percent of people whose broken bones fail to heal, researchers at the University of North Carolina at Chapel Hill have shown that transplantation of adult stem cells can improve healing of fractures.

Adult stem cells are specialized cells with the ability to regenerate tissue in response to damage. However, many patients lack sufficient numbers of these cells and thus cannot heal properly.

Researchers have used adult stem cells in a few cases to improve fracture healing, but further studies were needed to show that this method was truly effective and safe before it can be pursued as a new treatment.

Now scientists at UNC have provided the scientific foundation for future clinical trials of this approach by demonstrating in animal models that these cells can be used to repair broken bones.

This finding is critical to patients who lack the proper healing process and to individuals prone to broken bones, such as those with osteoporosis and the rare genetic condition known as brittle bone disease,” said Dr. Anna Spagnoli, associate professor of pediatrics and biomedical engineering in the UNC School of Medicine and senior author on the study.

The study, presented Monday, June 16 at the annual Endocrine Society meeting in San Francisco by the first author, Froilan Granero-Molto, Ph.D., post-doctoral associate researcher in UNC’s pediatrics department, is the first to visualize the action of transplanted adult stem cells as they mend fractures in mice.

more...

http://www.newswise.com/articles/view/541730/

manouli · 06-16-2008, 05:53 PM

An expanding arsenal of stem cell techniques
By John Timmer | Published: June 16, 2008 - 01:33PM CT

One of the sure signs of progress in a field in the biosciences is when the breakthroughs that are announced in high-profile publications become available as a kit. RNA interference went that route, as decade-old papers won Nobel Prizes that were handed out a few years after companies started offering to ship you RNAi based on sequences you could submit via your web browser. We're not quite at the kit stage for stem cells, but a number of publications suggest we're getting closer and closer to it. We'll take a look at two that were published over the weekend.

The first came out in Nature Methods, and addresses the need to maintain stem cells in culture without having them differentiate into mature cell types. Researchers have identified a set of proteins, such as LIF and SCF, that help keep cells in a stem-cell state, but the short lifetime of proteins in solution means that the LIF and SCF have to be replaced with a fresh supply every couple of days.

more....

http://arstechnica.com/journals/scie...ell-techniques

manouli · 06-16-2008, 09:05 PM

Wine find
By Nathan Seppa
June 16th, 2008
Web edition

Red wine component resveratrol might fight obesity, lab tests show
Resveratrol, the chemical in red grape skins that seems to underlie the healthful effects of red wine, limits the number of fat cells that can develop from stem cells, a new study finds.

The finding, combined with resveratrol’s other beneficial effects at the cellular level, might explain in part the French paradox, said study coauthor Martin Wabitsch, a pediatric endocrinologist at the University of Ulm in Germany, who presented the work Monday in San Francisco during a meeting of the Endocrine Society. The paradox refers to the observation that people in France seem to have a low incidence of coronary heart disease and seem to stay thin despite a diet high in fats.

Scientists formerly believed that people have a set number of fat cells at birth, but now widely understand that stem cells can differentiate into full-fledged fat cells well into adulthood and old age.

In the new study, laboratory tests on human cells showed that resveratrol inhibits the number of nascent fat cells that grow into mature fat cells, Wabitsch said. This could limit the addition of fatty tissue in the body, he hypothesizes. If fats and carbohydrates from food cannot be larded into fat cells, they are typically broken down and burned as energy instead, he says.

Thus, fat deposition might not depend solely on the amount of energy consumed, he says. With resveratrol, he said, “It might be metabolized more actively instead of stored.”

more...

http://www.sciencenews.org/view/gene...itle/Wine_find

manouli · 06-17-2008, 07:17 PM

Millipore Awards Grant to Stem Cell Researcher at the Scripps Research Institute of California

BILLERICA, Mass., June 18, 2008 - TIME: 9:00 a.m. Pacific Time LOCATION: San Diego Convention Center, Conference Room 7b; 111 W. Harbor Drive, San Diego, CA 92101 DETAILS: Millipore will award Dr. Jeanne Loring of the Scripps Research Institute in La Jolla, Calif., a significant grant for her research on MicroRNAs in stem cell pluripotence and self renewal. The award will be presented during the Bio International Convention in San Diego, Calif., by Martin Madaus, Millipore CEO and President. This is the first major grant Millipore has offered to a stem cell researcher on the West Coast.

more...

http://www.pharmalive.com/News/index...&categoryid=15

manouli · 06-17-2008, 07:20 PM

Key Developmental Pathway Activates Lung Stem Cells

ScienceDaily (Jun. 18, 2008) — Researchers from the University of Pennsylvania School of Medicine found that the activation of a molecular pathway important in stem cell and developmental biology leads to the increase in lung stem cells. Harnessing this knowledge could help develop therapies for lung-tissue repair after injury or disease.

The investigators recently published their findings online in advance of print publication in Nature Genetics.

"The current findings show that increased activity of the Wnt pathway leads to expansion of a type of lung stem cell called bronchioalveolar stem cells," says senior author Edward Morrisey, Ph.D., Associate Professor of Medicine and Cell and Developmental Biology.

more....

http://www.sciencedaily.com/releases...0617143634.htm

manouli · 06-17-2008, 07:23 PM

Stem cell donor drive set for June 21 to help area resident

LITTLE FERRY (June 19, 2008) — A stem cell registration drive will be held for Al Alberti, Lyndhurst resident, husband and father of three children, on Saturday, June 21, 10 a.m. to 1 p.m., at Memorial School (multi-purpose room) 130 Liberty St., Little Ferry.

more..
http://leadernewspapers.net/modules....ticle&sid=7403

manouli · 06-18-2008, 08:17 AM

Researchers to test stem cells to treat Crohn's
BY DELTHIA RICKS | Newsday Staff Writer
11:50 PM EDT, June 17, 2008

Stem cells may force Crohn's disease into retreat, say Long Island medical investigators who are embarking on a pioneering analysis that targets patients who've failed other therapies.

Cases of Crohn's disease have skyrocketed since World War II, jumping tenfold in the United States and raising questions about the disease's genetics and demography. It is one of two disorders -- the other is ulcerative colitis -- that are known as inflammatory bowel diseases. Before the 20th century there was no recorded evidence of either.

Dr. Robert Richards, director of clinical research in the gastroenterology division at Stony Brook University Medical Center, is embarking on a clinical study involving the infusion of adult stem cells, which he and other researchers theorize may force the condition into retreat. His analysis is part of a multicenter trial nationwide, focusing on patients with moderate to severe forms of the disease.

more....

http://www.newsday.com/news/health/n...tory?track=rss

Thread Tools
Show Printable Version Email this Page
Display Modes
Linear Mode Switch to Hybrid Mode Switch to Threaded Mode

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Highlights and (My Reasons for) Hope from 2006	Wise Young	Cure	105	02-14-2007 09:32 AM
Announcement by NIH concerning stem cell sources	Wise Young	Cure	3	06-27-2006 01:25 AM
Republican Senate Leader Frist to back ESC research!	Donny247	Funding, Legislation, & Advocacy	45	08-09-2005 08:00 AM
CAMR Calls for Bush's Help in Fully Implementing Stem Cell Policy	antiquity	Cure	4	08-07-2002 11:30 AM

06-16-2008, 09:32 AM	#1891
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	Old stem cells can regain youth: Study 16 Jun 2008, 1355 hrs IST,IANS NEW YORK: Stem cells in an old tissue are still able to perform regenerative functions, provided they receive appropriate chemical signals, according to a new study. Earlier studies have shown that when old tissue is placed in an environment of young blood, the stem cells behave as if they are young again. A team of bio-engineers at California University, led by Irina Conboy, identified two key pathways that determine how well adult stem cells repair and replace damaged tissue. more.... http://timesofindia.indiatimes.com/H...ow/3133555.cms

06-16-2008, 09:41 AM	#1892
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	oh boy.... Saturday, June 14, 2008 Pro-Life Dem Lawmaker Blasts Embryonic Stem Cell Research Plan [Jack Fowler] New York is set to spend $600 million in taxpayer dollars on stem cell research. A recently released draft plan drooling over the potential of embryonic cells to cure a variety of diseases has drawn this blast from Rev. Ruben Diaz, the state senate's sole pro-life Democrat: June 13, 2008 Judy Doesschate, J.D. Director of Board Operations Wadsworth Center New York State Department of Health Empire State Plaza, Box 509 Albany, NY 12208-0509 Dear Ms. Doesschate: This letter is to express my response to the Empire State Stem Cell Board’s strategic framework that will guide New York State’s $600 Million, 11-year investment in stem cell research. The report expresses the intention that New York’s investment in stem cell research will hold the promise of revitalizing and strengthening New York’s biomedical research industry, saving lives, and improving health. This is a false hope. The Empire State Stem Cell Board’s draft report discusses a great potential that may come from embryonic stem cells. To date, there have been no known cures - nor the promise of any cure - from embryonic stem cells. Research in the area of embryonic stem cells is the twenty-first century’s version of alchemy. Medical researchers in this area are pursuing the “gold rush” to create an organ replacement industry to stave off illness and disease. While the practice of alchemy only involved the use of base metals, embryonic stem cell research requires the sacrifice of precious living human fetuses as fodder for their experiments. more... http://corner.nationalreview.com/pos...AxOGE3NDkyM2I=

06-16-2008, 12:10 PM	#1893
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	Treating Stress Urinary Incontinence With Stem Cells Reported From The Annual Meeting Of The American Urological Association Article Date: 15 Jun 2008 - 3:00 PDT ORLANDO, FL (UroToday.com) - Dr. Rodriguez discussed use of stem cells for treating SUI (Stress Urinary Incontinence). A stem cell is embryonic, adult, or engineered. Embryonic stem cells come from the blastocyst which is totipotent or pluripotent. These cells are immortal, identical clonal cells with long-term self renewal. Controversies include possible tumor formation, the difficulty maintaining cell cultures and ethical issues. Embryonic stem cells can differentiate into ectoderm, mesoderm and endoderm. Adult stem cells include hematopoetic stem cells, such as derived from bone marrow. This requires a bone marrow harvest, with low yield and difficulty to expand clones. A variety of other tissues have been studied such as muscle or fat. This avoids ethical issues and it is easier to expand clones. However they are not immortal, identical, or totipotent and have no specific markers for identification. more... http://www.medicalnewstoday.com/articles/111309.php

06-16-2008, 05:39 PM	#1894
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	this is good news. Adult Stem Cells Aid Fracture Healing; Study Lays Groundwork for Potential Treatments Newswise — In an approach that could become a new treatment for the 10 to 20 percent of people whose broken bones fail to heal, researchers at the University of North Carolina at Chapel Hill have shown that transplantation of adult stem cells can improve healing of fractures. Adult stem cells are specialized cells with the ability to regenerate tissue in response to damage. However, many patients lack sufficient numbers of these cells and thus cannot heal properly. Researchers have used adult stem cells in a few cases to improve fracture healing, but further studies were needed to show that this method was truly effective and safe before it can be pursued as a new treatment. Now scientists at UNC have provided the scientific foundation for future clinical trials of this approach by demonstrating in animal models that these cells can be used to repair broken bones. This finding is critical to patients who lack the proper healing process and to individuals prone to broken bones, such as those with osteoporosis and the rare genetic condition known as brittle bone disease,” said Dr. Anna Spagnoli, associate professor of pediatrics and biomedical engineering in the UNC School of Medicine and senior author on the study. The study, presented Monday, June 16 at the annual Endocrine Society meeting in San Francisco by the first author, Froilan Granero-Molto, Ph.D., post-doctoral associate researcher in UNC’s pediatrics department, is the first to visualize the action of transplanted adult stem cells as they mend fractures in mice. more... http://www.newswise.com/articles/view/541730/

06-16-2008, 05:53 PM	#1895
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	An expanding arsenal of stem cell techniques By John Timmer \| Published: June 16, 2008 - 01:33PM CT One of the sure signs of progress in a field in the biosciences is when the breakthroughs that are announced in high-profile publications become available as a kit. RNA interference went that route, as decade-old papers won Nobel Prizes that were handed out a few years after companies started offering to ship you RNAi based on sequences you could submit via your web browser. We're not quite at the kit stage for stem cells, but a number of publications suggest we're getting closer and closer to it. We'll take a look at two that were published over the weekend. The first came out in Nature Methods, and addresses the need to maintain stem cells in culture without having them differentiate into mature cell types. Researchers have identified a set of proteins, such as LIF and SCF, that help keep cells in a stem-cell state, but the short lifetime of proteins in solution means that the LIF and SCF have to be replaced with a fresh supply every couple of days. more.... http://arstechnica.com/journals/scie...ell-techniques

06-16-2008, 09:05 PM	#1896
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	Wine find By Nathan Seppa June 16th, 2008 Web edition Red wine component resveratrol might fight obesity, lab tests show Resveratrol, the chemical in red grape skins that seems to underlie the healthful effects of red wine, limits the number of fat cells that can develop from stem cells, a new study finds. The finding, combined with resveratrol’s other beneficial effects at the cellular level, might explain in part the French paradox, said study coauthor Martin Wabitsch, a pediatric endocrinologist at the University of Ulm in Germany, who presented the work Monday in San Francisco during a meeting of the Endocrine Society. The paradox refers to the observation that people in France seem to have a low incidence of coronary heart disease and seem to stay thin despite a diet high in fats. Scientists formerly believed that people have a set number of fat cells at birth, but now widely understand that stem cells can differentiate into full-fledged fat cells well into adulthood and old age. In the new study, laboratory tests on human cells showed that resveratrol inhibits the number of nascent fat cells that grow into mature fat cells, Wabitsch said. This could limit the addition of fatty tissue in the body, he hypothesizes. If fats and carbohydrates from food cannot be larded into fat cells, they are typically broken down and burned as energy instead, he says. Thus, fat deposition might not depend solely on the amount of energy consumed, he says. With resveratrol, he said, “It might be metabolized more actively instead of stored.” more... http://www.sciencenews.org/view/gene...itle/Wine_find

06-17-2008, 07:17 PM	#1897
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	Millipore Awards Grant to Stem Cell Researcher at the Scripps Research Institute of California BILLERICA, Mass., June 18, 2008 - TIME: 9:00 a.m. Pacific Time LOCATION: San Diego Convention Center, Conference Room 7b; 111 W. Harbor Drive, San Diego, CA 92101 DETAILS: Millipore will award Dr. Jeanne Loring of the Scripps Research Institute in La Jolla, Calif., a significant grant for her research on MicroRNAs in stem cell pluripotence and self renewal. The award will be presented during the Bio International Convention in San Diego, Calif., by Martin Madaus, Millipore CEO and President. This is the first major grant Millipore has offered to a stem cell researcher on the West Coast. more... http://www.pharmalive.com/News/index...&categoryid=15

06-17-2008, 07:20 PM	#1898
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	Key Developmental Pathway Activates Lung Stem Cells ScienceDaily (Jun. 18, 2008) — Researchers from the University of Pennsylvania School of Medicine found that the activation of a molecular pathway important in stem cell and developmental biology leads to the increase in lung stem cells. Harnessing this knowledge could help develop therapies for lung-tissue repair after injury or disease. The investigators recently published their findings online in advance of print publication in Nature Genetics. "The current findings show that increased activity of the Wnt pathway leads to expansion of a type of lung stem cell called bronchioalveolar stem cells," says senior author Edward Morrisey, Ph.D., Associate Professor of Medicine and Cell and Developmental Biology. more.... http://www.sciencedaily.com/releases...0617143634.htm

06-17-2008, 07:23 PM	#1899
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	Stem cell donor drive set for June 21 to help area resident LITTLE FERRY (June 19, 2008) — A stem cell registration drive will be held for Al Alberti, Lyndhurst resident, husband and father of three children, on Saturday, June 21, 10 a.m. to 1 p.m., at Memorial School (multi-purpose room) 130 Liberty St., Little Ferry. more.. http://leadernewspapers.net/modules....ticle&sid=7403

06-18-2008, 08:17 AM	#1900
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,356	Researchers to test stem cells to treat Crohn's BY DELTHIA RICKS \| Newsday Staff Writer 11:50 PM EDT, June 17, 2008 Stem cells may force Crohn's disease into retreat, say Long Island medical investigators who are embarking on a pioneering analysis that targets patients who've failed other therapies. Cases of Crohn's disease have skyrocketed since World War II, jumping tenfold in the United States and raising questions about the disease's genetics and demography. It is one of two disorders -- the other is ulcerative colitis -- that are known as inflammatory bowel diseases. Before the 20th century there was no recorded evidence of either. Dr. Robert Richards, director of clinical research in the gastroenterology division at Stony Brook University Medical Center, is embarking on a clinical study involving the infusion of adult stem cells, which he and other researchers theorize may force the condition into retreat. His analysis is part of a multicenter trial nationwide, focusing on patients with moderate to severe forms of the disease. more.... http://www.newsday.com/news/health/n...tory?track=rss