Cytori Therapeutics Presents Data Demonstrating Adipose Stem Cells Form Blood Vessels and Improve Blood Flow

[Leif]

http://www.pharmalive.com//News/inde...&categoryid=40

Question:

Since these stem cells spontaneously form capillary networks in vitro, could it also be a technique to form a new capillary network where my spinal cord is damaged?

And thereby make the damaged site ready for derived embryonic stem cells to form new neurons and axons?

See also this thread; http://carecure.org/forum/showthread.php?t=49947

Leif

SAN DIEGO--(BUSINESS WIRE)--Oct 24, 2005 - Cytori Therapeutics, Inc. (Frankfurt:XMP) today presented research results from two studies demonstrating that adipose stem and regenerative cells have an ability to form blood vessels and improve blood flow. In an in vivo preclinical study, adipose stem and regenerative cells restored blood flow to severely injured hind limbs. A second study showed that these cells spontaneously form capillary networks in vitro. The data from both studies were presented at the 8th Annual Tissue Engineering Society International Conference and Exhibition in Shanghai, P.R. China.

"These results are consistent with our previously published data which strongly suggest that adipose stem and regenerative cells contribute to repair and healing through their ability to form new blood vessels and improve the blood flow in existing vessels supplying injured tissues," stated Marc H. Hedrick, M.D., President for Cytori Therapeutics. "Our findings consistently demonstrate the potential of these cells in the treatment of cardiovascular disease, including heart attacks, congestive heart failure and peripheral vascular disease."


In an oral presentation, Cytori reported that adipose stem and regenerative cells injected intravenously into mice improved blood flow and rescued hind limbs two weeks after the femoral artery, the main artery supplying blood to the lower extremities, was surgically severed. In the in vitro study, Cytori found that after three weeks, adipose stem and regenerative cells spontaneously formed capillary networks without the use of growth factors traditionally required to coax cells into forming blood vessels. Additionally, the cells expressed proteins that are consistent with those known to contribute to blood vessel growth.

More on link at the top.

[Leif]

Wise. I understands you are buisy – but is this resarch interesting? I was also thinking about this resarch in conjunction with angiogenesis?

[Wise Young]

Originally Posted by Leif

Wise. I understands you are buisy – but is this resarch interesting? I was also thinking about this resarch in conjunction with angiogenesis?

Angiogenesis occurs robustly in all tissues after injury. We do not need exogenous stem cells to promote angiogenesis. The injury site in the spinal cord, for example, is heavily vascularized without days after injury. It is of course interesting from a scientific point of view that adipose (fat) cells can participate in angiogenesis. I have not read the paper but it would even be more interesting if the authors had actually shown that differentiated adipose cellls will participate in angiogenesis rather than some mesenchymal stem cells in adipose tissue that contributes to angiogenesis. If adipose cells are doing it, this would argue strongly for the differentiated adipose cells "de-differentiating" to become stem cells that then can produce blood vessels and endothelium.

Wise.