|07-31-2005, 09:51 PM||#1|
Join Date: Jul 2001
Location: New Brunswick, NJ, USA
Brazel, et al. (2005). Sox2 expression defines a heterogeneous population of neurosphere-forming cells in the adult murine brain.
The Rao laboratory at NIH reports that the Sox2 gene is expressed in neurogenic regions of the mouse brain, using a Sox23:EGFP transgenic mouse. They then showed that these cells indeed form neurospheres when isolated from adult mouse brains. They propose that Sox2 is a unifying marker for neurosphere forming cells but not all the cells maintain their ability to form all neural cell types.
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