OXFORD BIOMEDICA PRESENTS ENCOURAGING INNUREX(R) PRECLINICAL EFFICACY DATA IN SPINAL CORD INJURY

Max · 06-03-2005, 05:47 AM

OXFORD BIOMEDICA PRESENTS ENCOURAGING INNUREX(R) PRECLINICAL EFFICACY DATA IN SPINAL CORD INJURY
OXFORD, UK -- (MARKET WIRE) -- 06/03/2005 --

FOR IMMEDIATE RELEASE 3 JUNE 2005

OXFORD BIOMEDICA PRESENTS ENCOURAGING INNUREX(R) PRECLINICAL EFFICACY
DATA IN SPINAL CORD INJURY

- Presentation at the 8th Annual Meeting of the American Society
of Gene Therapy, 1-5 June 2005, in St. Louis, Missouri, USA -

Oxford, UK: 3 June 2005 - Oxford BioMedica (LSE: OXB), the leading gene therapy company, is today presenting encouraging Innurex preclinical efficacy data at the Annual Meeting of the American Society of Gene Therapy (ASGT) in St. Louis, Missouri, USA. The data show, for the first time, that Innurex, Oxford BioMedica's gene-based product for nerve regeneration, is able to induce nerve repair in spinal cord (corticospinal tract) injuries and restore both sensory and motor functions in a placebo controlled preclinical model. Very few products have been able to show nerve repair in models of spinal cord injury and no products to date have achieved this in the clinical setting.

In this preclinical study of spinal cord injury, Innurex stimulated cellular repair in the form of nerve regrowth across the injury. Functional repair was assessed by measuring time taken or movement during certain tasks, such as ladder crossing and grid walking. Following Innurex treatment, there was a statistically significant improvement in functional ability compared to placebo on most measures. These new data add to previous observations in preclinical models of avulsion (stretch) injury and suggest that Innurex may be useful in the clinical treatment of both stretch injury and the technically more challenging spinal cord damage
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Sally's Mom · 06-03-2005, 08:48 AM

Wise,
Could this type of "sprouting" help Sally? She lost her axons due to a virus (7 years post).

Thanks,
Sandi

MHemenway · 06-03-2005, 09:32 AM

Dr. Young,
Do you know if something like this would work for chronic injuries?

Thanks,
Mary

Radek · 06-03-2005, 01:03 PM

Next news about innurex on www.oxfordbiomedica.co.uk

angel7 · 06-03-2005, 02:21 PM

Max,

First thank you for posting all of your articles. Second "Acute" or "Chronic?"

Deb

Leo · 06-03-2005, 03:26 PM

Not sure if it's still good but here's email to try.

A.Kingsman@OxfordBiomedica.co.uk

on their web site there's a contact person for future clinical trials, couldn't hurt to see what they say.

"All you have to decide is what to do with the time that is given you."
Gandolf the Gray

Steven Edwards · 06-03-2005, 03:46 PM

Innurex works through the RAR-beta2 receptor, which appears to play a part in regeneration [vs neuroprotection], which should work in chronics.

-Steven
...let's tell it how it is, and how it could be... how it was, and of course, how it should be

sbdspray · 06-03-2005, 04:47 PM

do the majority of us have to wait "decades and decades", to get help here?

sherman brayton

Steven Edwards · 06-03-2005, 04:59 PM

They are working toward establishing pre-clinical safety to move it into human trials. Similar to Geron, they have a profit motive and should be moving as quickly as they can to get it working.

-Steven
...let's tell it how it is, and how it could be... how it was, and of course, how it should be

Schmeky · 06-03-2005, 05:29 PM

"Stretch" injury? Why is it virtually all lab work is based on transections, hemisections, and stretch models of injury when 99% of us are contused? I am confused (and definitely contused) so are the labs confused about us being contused?

Sounds like the axon bodies were stretched to the point of disconnection in this instance. How soon was repair initiated after the injury? There must have been no scarring to deal with.

06-03-2005, 05:47 AM	#1
Max Senior Member Join Date: Jul 2001 Location: Montreal,Province of Quebec, CANADA Posts: 15,036	OXFORD BIOMEDICA PRESENTS ENCOURAGING INNUREX(R) PRECLINICAL EFFICACY DATA IN SPINAL CORD INJURY OXFORD BIOMEDICA PRESENTS ENCOURAGING INNUREX(R) PRECLINICAL EFFICACY DATA IN SPINAL CORD INJURY OXFORD, UK -- (MARKET WIRE) -- 06/03/2005 -- FOR IMMEDIATE RELEASE 3 JUNE 2005 OXFORD BIOMEDICA PRESENTS ENCOURAGING INNUREX(R) PRECLINICAL EFFICACY DATA IN SPINAL CORD INJURY - Presentation at the 8th Annual Meeting of the American Society of Gene Therapy, 1-5 June 2005, in St. Louis, Missouri, USA - Oxford, UK: 3 June 2005 - Oxford BioMedica (LSE: OXB), the leading gene therapy company, is today presenting encouraging Innurex preclinical efficacy data at the Annual Meeting of the American Society of Gene Therapy (ASGT) in St. Louis, Missouri, USA. The data show, for the first time, that Innurex, Oxford BioMedica's gene-based product for nerve regeneration, is able to induce nerve repair in spinal cord (corticospinal tract) injuries and restore both sensory and motor functions in a placebo controlled preclinical model. Very few products have been able to show nerve repair in models of spinal cord injury and no products to date have achieved this in the clinical setting. In this preclinical study of spinal cord injury, Innurex stimulated cellular repair in the form of nerve regrowth across the injury. Functional repair was assessed by measuring time taken or movement during certain tasks, such as ladder crossing and grid walking. Following Innurex treatment, there was a statistically significant improvement in functional ability compared to placebo on most measures. These new data add to previous observations in preclinical models of avulsion (stretch) injury and suggest that Innurex may be useful in the clinical treatment of both stretch injury and the technically more challenging spinal cord damage http://www.marketwire.com/mw/release...lease_id=88028 http://stores.ebay.com/MAKSYM-Variety-Store

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06-03-2005, 08:48 AM	#2
Sally's Mom Senior Member Join Date: Jan 2005 Location: Tacoma, Wa. Posts: 119	Wise, Could this type of "sprouting" help Sally? She lost her axons due to a virus (7 years post). Thanks, Sandi

06-03-2005, 09:32 AM	#3
MHemenway Member Join Date: Jan 2005 Location: Beaver, PA USA Posts: 86	Dr. Young, Do you know if something like this would work for chronic injuries? Thanks, Mary

06-03-2005, 01:03 PM	#4
Radek Junior Member Join Date: May 2004 Location: Ostrava, Czech Republic Posts: 4	Next news about innurex on www.oxfordbiomedica.co.uk

06-03-2005, 02:21 PM	#5
angel7 Senior Member Join Date: Oct 2001 Location: Alvin,Texas Posts: 1,961	Max, First thank you for posting all of your articles. Second "Acute" or "Chronic?" Deb

06-03-2005, 03:26 PM	#6
Leo Senior Member Join Date: Jul 2001 Location: Yankton, South Dakota Posts: 3,950	Not sure if it's still good but here's email to try. A.Kingsman@OxfordBiomedica.co.uk on their web site there's a contact person for future clinical trials, couldn't hurt to see what they say. "All you have to decide is what to do with the time that is given you." Gandolf the Gray

06-03-2005, 03:46 PM	#7
Steven Edwards Administrator Join Date: Jul 2001 Location: Acme Labs Posts: 15,530	Innurex works through the RAR-beta2 receptor, which appears to play a part in regeneration [vs neuroprotection], which should work in chronics. -Steven ...let's tell it how it is, and how it could be... how it was, and of course, how it should be

06-03-2005, 04:47 PM	#8
sbdspray Senior Member Join Date: Apr 2002 Location: katonah , ny, usa Posts: 494	do the majority of us have to wait "decades and decades", to get help here? sherman brayton

06-03-2005, 04:59 PM	#9
Steven Edwards Administrator Join Date: Jul 2001 Location: Acme Labs Posts: 15,530	They are working toward establishing pre-clinical safety to move it into human trials. Similar to Geron, they have a profit motive and should be moving as quickly as they can to get it working. -Steven ...let's tell it how it is, and how it could be... how it was, and of course, how it should be

06-03-2005, 05:29 PM	#10
Schmeky Senior Member Join Date: Sep 2002 Location: West Monroe, LA, USA Posts: 3,398	"Stretch" injury? Why is it virtually all lab work is based on transections, hemisections, and stretch models of injury when 99% of us are contused? I am confused (and definitely contused) so are the labs confused about us being contused? Sounds like the axon bodies were stretched to the point of disconnection in this instance. How soon was repair initiated after the injury? There must have been no scarring to deal with.