Wise - OEG Question

Christopher Paddon · 04-16-2003, 11:09 PM

Wise, thanks once again for your wonderfully clear answers to all our questions!

I was wondering about what you said about Dr Huang's injecting cells into the healthy spinal cord above and below the injury site, do you think the Brisbane team is aware of this? It seems from what you say that OEG transplants into the injury site are likely to die off.

If the blood brain barrier is broken at the injury site how is any migrating tissue going to survive? If the OEG cells migrate from the healthy cord and form a bridge and axons grow through the bridge won't the environment still be toxic?

Sorry, last question - if trials were successful in Brisbane or China could surgeons in the USA, UK and NZ perform the procedure or are there requirements for the experiments either in humans or rats to be repeated in the respective countries?

Thanks

Chris

ps: happy easter

Wise Young · 04-17-2003, 05:27 AM

chris2, I told the brisbane group about Dr. Huang. They were hoping to visit him. I think that fear of SARS may have postponed the visit. Wise.

Wise Young · 04-17-2003, 12:34 PM

Chris2, I think the loss of transplanted cells from the injury site is a combination of immune rejection and inflammatory condition of the injury site, i.e. many inflammatory cells invading the area. Wise.

Christopher Paddon · 04-17-2003, 08:53 PM

Thanks Wise

How come the cells die if transplanted into the injury site but when transplanted into the healthy cord they migrate into the injury site without dying? Is there any evidence in this method (injecting above and below the injury site) that axons keep going once they've crossed the injury site?

Chris

Wise Young · 04-17-2003, 09:25 PM

Chris2,

The cells may need stabilize. In acutely contused spinal cords, they probably die as they migrate into the impact site. However, over time, as the inflammatory state of the injury site subsides, the cells make their way in.

Wise.

04-16-2003, 11:09 PM	#1
Christopher Paddon Senior Member Join Date: Oct 2001 Location: New Zealand Posts: 3,207	Wise - OEG Question Wise, thanks once again for your wonderfully clear answers to all our questions! I was wondering about what you said about Dr Huang's injecting cells into the healthy spinal cord above and below the injury site, do you think the Brisbane team is aware of this? It seems from what you say that OEG transplants into the injury site are likely to die off. If the blood brain barrier is broken at the injury site how is any migrating tissue going to survive? If the OEG cells migrate from the healthy cord and form a bridge and axons grow through the bridge won't the environment still be toxic? Sorry, last question - if trials were successful in Brisbane or China could surgeons in the USA, UK and NZ perform the procedure or are there requirements for the experiments either in humans or rats to be repeated in the respective countries? Thanks Chris ps: happy easter

Thread Tools
Show Printable Version Email this Page
Display Modes
Linear Mode Switch to Hybrid Mode Switch to Threaded Mode

04-17-2003, 05:27 AM	#2
Wise Young Administrator Join Date: Jul 2001 Location: New Brunswick, NJ, USA Posts: 37,988	chris2, I told the brisbane group about Dr. Huang. They were hoping to visit him. I think that fear of SARS may have postponed the visit. Wise.

04-17-2003, 12:34 PM	#3
Wise Young Administrator Join Date: Jul 2001 Location: New Brunswick, NJ, USA Posts: 37,988	Chris2, I think the loss of transplanted cells from the injury site is a combination of immune rejection and inflammatory condition of the injury site, i.e. many inflammatory cells invading the area. Wise.

04-17-2003, 08:53 PM	#4
Christopher Paddon Senior Member Join Date: Oct 2001 Location: New Zealand Posts: 3,207	Thanks Wise How come the cells die if transplanted into the injury site but when transplanted into the healthy cord they migrate into the injury site without dying? Is there any evidence in this method (injecting above and below the injury site) that axons keep going once they've crossed the injury site? Chris

04-17-2003, 09:25 PM	#5
Wise Young Administrator Join Date: Jul 2001 Location: New Brunswick, NJ, USA Posts: 37,988	Chris2, The cells may need stabilize. In acutely contused spinal cords, they probably die as they migrate into the impact site. However, over time, as the inflammatory state of the injury site subsides, the cells make their way in. Wise.