PTEN Study

[rjames]

Here's a great video about the recent work regarding PTEN from our friends at the Reeve-Irvine Research Center
http://www.vimeo.com/18333473

[dr.zapp]

I saw the paper about this, looked very interesting... http://www.ncbi.nlm.nih.gov/pubmed/20694004
My thoughts on this however, are what are the long term effects of such a treatment? PTEN is a tumor suppressor, it is down-regulated in all sorts of different cancers. It is a main player in cell cycle regulation. In fact, a PTEN conditional knock-out mouse is one we use to study phaeochromocytomas... http://www.ncbi.nlm.nih.gov/pubmed/19142977
Sure, you may help nerve growth... but get cancer in 5 years. Not saying this is not important research, just that the media hype around it has been curiously absent of the actual role of PTEN in cells.
However, using RNAi, it would be possible to do transient PTEN knock-down in the CNS... hmmmm.

[GRAMMY]

Originally Posted by rjames

Here's a great video about the recent work regarding PTEN from our friends at the Reeve-Irvine Research Center
http://www.vimeo.com/18333473

Fantastic video rjames! Thanks for putting up the link for everyone!
This is really great!!!

[paolocipolla]

Originally Posted by rjames

Here's a great video about the recent work regarding PTEN from our friends at the Reeve-Irvine Research Center
http://www.vimeo.com/18333473

Thanks rjames,

do you know if they have been able to see functional returns associated to the regeneration they have obtained?

[rjames]

Originally Posted by paolocipolla

Thanks rjames,

do you know if they have been able to see functional returns associated to the regeneration they have obtained?

Paolocipolla I don't know if they have seen functional return but in March at their Meet the Scientist open house I will find out.

[jhope]

so just make the pill. lol just one more "tip of the iceberg"

[rjames]

Originally Posted by jhope

so just make the pill. lol just one more "tip of the iceberg"

Jhope, I agree. We need to do some reverse engineering and take all these icebergs of research and make them into a glacier of a cure!!!!

[paolocipolla]

Originally Posted by rjames

Paolocipolla I don't know if they have seen functional return but in March at their Meet the Scientist open house I will find out.

Thanks rjames.

As I understand, so far, in the publisced studies thay have sacrificed the mouse soon after treatment to investigate what happened early at the injury site.
Also, as I understand, they have used transection model, just lately also contusion model (where regeration was a bit less).

That was several moths ago, maybe a year, so I would guess they have made further progresses now.

Thanks in advance.

Paolo

[Peders]

I wouldn't mind going from a C-4 to a C7!

[Han Solo]

Wow, that was interesting! That could be something BIG!