wise, I don't know if you can answer this but...

[lunasicc42]

regarding any therapy, including your own, how does therapy progress? I don't expect that you apply said therapy and BAM!!! walking.

So based on animal tests.... How does recovery "evolve"?

[Buck503]

I've wondered what will happen when people can feel their
urethras again after the years of cathing?

[Wise Young]

Originally Posted by lunasicc42

regarding any therapy, including your own, how does therapy progress? I don't expect that you apply said therapy and BAM!!! walking.

So based on animal tests.... How does recovery "evolve"?

I suspect that the course of recovery after a regenerative therapy is applied to the spinal cord would be similar to what happens to a person who has suffered from an incomplete spinal cord injury. Presumably, the regeneration therapy would make a person who has a complete injury incomplete or would make a person who has an incomplete injury more incomplete. There is first the time course of the regeneration, which may take a few months to see at the segments close to the injury site and perhaps a year or more to see recovery in more distal segments.

We are following the patients out for 6 weeks, 6 months, one year, and then two years after application of the therapy. We are planning to provide intensive locomotor training during the first 6-12 weeks after the therapy with the hopes that the patient will continue to do overground walking after that. It will be very difficult and may be impossibly expensive to provide more than 12 weeks of rehabilitation. In any case, we are hoping to do a phase 2 trial early next year in Brackenridge in Austin to assess the feasibility of doing intensive overground locomotor training of people with complete spinal cord injuries in the U.S. after umbilical cord blood mononuclear cell transplants and lithium. The rehabilitation part of the protocol is the most difficult to get consensus on.

In general, most people who have incomplete spinal cord injury and cannot walk shortly after injury will recover ability to walk within one year after injury. So, I expect that we may see some locomotor improvement within a year after we get robust regeneration or sprouting from the therapies.

Wise.

[Wise Young]

Originally Posted by Buck_Nastier

I've wondered what will happen when people can feel their
urethras again after the years of cathing?

Buck, I think that they should. It might hurt a bit. Wise.