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Creating ideal neural cells for clinical use
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Creating ideal neural cells for clinical use
New protocol quickly and efficiently differentiates human embryonic stem cells into committed neural precursor cells
LA JOLLA, Calif., April 13, 2009 -- Investigators at the Burnham Institute for Medical Research (Burnham) have developed a protocol to rapidly differentiate human embryonic stem cells (hESCs) into neural progenitor cells that may be ideal for transplantation. The research, conducted by Alexei Terskikh. . . does not produce mutations in the cells and could be useful for clinical applications. The research was published on March 13 in the journal Cell Death and Differentiation.
When the C-NPCs created using the Terskikh protocol were transplanted into mice, they became active neurons and integrated into the cortex and olfactory bulb. The transplanted cells did not generate tumor outgrowth.
Dr. Terskikh notes that the extensive passaging (moving cells from plate to plate) required by some protocols to expand the numbers of neural precursor cells limits the plasticity of the cells, can introduce mutations and may lead to the expression of oncogenes. The Terskikh protocol avoids this by using efficient conversion of hESCs into primary neuroepithelial cells without the extensive passaging. (Source)
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...it's worse than we thought. it turns out the people at the white house are not secret muslims, they're nerds.
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04-14-2009, 04:59 PM
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