NIH to fund Centers for rodent models of SCI

Wise Young · 03-06-2002, 03:00 PM

http://www.eps.gov/spg/HHS/NIH/NINDS...SynopsisP.html

General Information

Document Type: Presolicitation Notice
Solicitation Number: NIH-NINDS-BAA-RFP-02-09
Posted Date: Mar 05, 2002
Original Response Date: May 20, 2002
Current Response Date: May 20, 2002
Archive Date: Jun 04, 2002
Classification Code: A -- Research & Development
Contracting Office Address

Department of Health and Human Services, National Institutes of Health, National Institute of Neurological Disorders and Stroke, 6001 Executive Boulevard, Neuroscience Center, Suite 3287, MSC 9531, Bethesda, MD, 20892-9531
Description

The National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, announces the availability of a Broad Agency Announcement/Request for Proposals (BAA/RFP) to establish training and research facilities that would support the study of rodent models of spinal cord injury (SCI). The NINDS is the lead governmental agency for the funding of research on SCI, and proposes to establish national Facilities of Research Excellence in SCI (FOR-SCI) that will train new researchers on best practices in the field of SCI, including the standards of current research methodology, analytical protocols and functional outcome evaluations. Under this BAA, these facilities will provide, in the same location, resources, capabilities and expertise in SCI research. These will include the ability to work with multiple standard models of injury in rats and/or mice, and the facilities and personnel for expert handling, care and the medical management of animals with SCI. They will have dedicated facilities and expertise for conducting surgery, including microsurgery such as transplants and grafts, and for cellular analyses ranging from neuroanatomy and histology to electrophysiology and other cutting-edge technologies. These facilities will also provide training for individuals from graduate students to faculty, both within and outside of the organization, to promote consistency of procedures and practices across laboratories. A facility/center should also be able to provide training on the assessment of standard outcome measures and to participate in the development of new and relevant means of evaluating recovery from spinal cord dysfunction. Another role of the support shall be to review and replicate novel treatments for SCI, and to compare the efficacy of different treatments in a standardized environment with a minimum of variability in surgery, animal care, outcome evaluation and cellular analyses. Finally, these sites could be the nuclei/nexus for collaborative studies on SCI. It is anticipated that one or two cost-reimbursement type contracts will be made for a period of five years in September 2002. This is not a Request for Proposals (RFP). THIS SOLICITATION WILL BE AVAILABLE ELECTRONICALLY ONLY. BAA/Request for Proposal (BAA/RFP) No. NIH-NINDS-02-09 will be available electronically and may be accessed through the FedBizOpps (URL: http://www.fedbizopps.gov) or through the NINDS website at the following URL address: (http://www.ninds.nih.gov/funding/currentrfps.htm) 15 or more calendar days after the issuance of this synopsis. OFFERORS ARE RESPONSIBLE FOR ROUTINELY CHECKING THIS WEBSITE FOR ANY POSSIBLE SOLICITATION AMENDMENTS THAT MAY BE ISSUED. NO INDIVIDUAL NOTIFICATION OF ANY AMENDMENTS WILL BE PROVIDED. All responsible sources may submit a proposal, which shall be considered by the agency. Refer to numbered note 26. ****
Point of Contact

Laurie Leonard, Contracting Officer, Phone 301 496-1813, Fax 301 402-4225, Email ll44s@nih.gov - Laurie Leonard, Contracting Officer, Phone 301 496-1813, Fax 301 402-4225, Email ll44s@nih.gov

Sue Pendleton · 03-09-2002, 10:42 PM

Rodent models? Has this place been built yet at NIH or is this another "we're doing something, see, just not what you want done." I mean will any regenative therapies be made solely of human cells so that when something does work several steps can be jumped and head to primate or large animal and immediately to human phase 1s or is this how they plan on sharing the 2 viable and available pluipotent stem cell lines that are contaminated and not usable for human work?

03-06-2002, 03:00 PM	#1
Wise Young Administrator Join Date: Jul 2001 Location: New Brunswick, NJ, USA Posts: 37,975	NIH to fund Centers for rodent models of SCI http://www.eps.gov/spg/HHS/NIH/NINDS...SynopsisP.html General Information Document Type: Presolicitation Notice Solicitation Number: NIH-NINDS-BAA-RFP-02-09 Posted Date: Mar 05, 2002 Original Response Date: May 20, 2002 Current Response Date: May 20, 2002 Archive Date: Jun 04, 2002 Classification Code: A -- Research & Development Contracting Office Address Department of Health and Human Services, National Institutes of Health, National Institute of Neurological Disorders and Stroke, 6001 Executive Boulevard, Neuroscience Center, Suite 3287, MSC 9531, Bethesda, MD, 20892-9531 Description The National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, announces the availability of a Broad Agency Announcement/Request for Proposals (BAA/RFP) to establish training and research facilities that would support the study of rodent models of spinal cord injury (SCI). The NINDS is the lead governmental agency for the funding of research on SCI, and proposes to establish national Facilities of Research Excellence in SCI (FOR-SCI) that will train new researchers on best practices in the field of SCI, including the standards of current research methodology, analytical protocols and functional outcome evaluations. Under this BAA, these facilities will provide, in the same location, resources, capabilities and expertise in SCI research. These will include the ability to work with multiple standard models of injury in rats and/or mice, and the facilities and personnel for expert handling, care and the medical management of animals with SCI. They will have dedicated facilities and expertise for conducting surgery, including microsurgery such as transplants and grafts, and for cellular analyses ranging from neuroanatomy and histology to electrophysiology and other cutting-edge technologies. These facilities will also provide training for individuals from graduate students to faculty, both within and outside of the organization, to promote consistency of procedures and practices across laboratories. A facility/center should also be able to provide training on the assessment of standard outcome measures and to participate in the development of new and relevant means of evaluating recovery from spinal cord dysfunction. Another role of the support shall be to review and replicate novel treatments for SCI, and to compare the efficacy of different treatments in a standardized environment with a minimum of variability in surgery, animal care, outcome evaluation and cellular analyses. Finally, these sites could be the nuclei/nexus for collaborative studies on SCI. It is anticipated that one or two cost-reimbursement type contracts will be made for a period of five years in September 2002. This is not a Request for Proposals (RFP). THIS SOLICITATION WILL BE AVAILABLE ELECTRONICALLY ONLY. BAA/Request for Proposal (BAA/RFP) No. NIH-NINDS-02-09 will be available electronically and may be accessed through the FedBizOpps (URL: http://www.fedbizopps.gov) or through the NINDS website at the following URL address: (http://www.ninds.nih.gov/funding/currentrfps.htm) 15 or more calendar days after the issuance of this synopsis. OFFERORS ARE RESPONSIBLE FOR ROUTINELY CHECKING THIS WEBSITE FOR ANY POSSIBLE SOLICITATION AMENDMENTS THAT MAY BE ISSUED. NO INDIVIDUAL NOTIFICATION OF ANY AMENDMENTS WILL BE PROVIDED. All responsible sources may submit a proposal, which shall be considered by the agency. Refer to numbered note 26. **** Point of Contact Laurie Leonard, Contracting Officer, Phone 301 496-1813, Fax 301 402-4225, Email ll44s@nih.gov - Laurie Leonard, Contracting Officer, Phone 301 496-1813, Fax 301 402-4225, Email ll44s@nih.gov

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03-09-2002, 10:42 PM	#2
Sue Pendleton Moderator Join Date: Jul 2001 Location: Wisconsin USA Posts: 9,112	Rodent models? Has this place been built yet at NIH or is this another "we're doing something, see, just not what you want done." I mean will any regenative therapies be made solely of human cells so that when something does work several steps can be jumped and head to primate or large animal and immediately to human phase 1s or is this how they plan on sharing the 2 viable and available pluipotent stem cell lines that are contaminated and not usable for human work?