Magnetic Resonance Imaging Studies of Motor and Thought Processes

[Wise Young]

Magnetic Resonance Imaging Studies of Motor and Thought Processes

This study is currently recruiting patients.

Sponsored by

National Institute of Neurological Disorders and Stroke (NINDS)

Purpose

Magnetic resonance imaging (MRI) is a diagnostic tool that creates high quality images of the human body without the use of X-ray (radiation). MRI is especially useful when studying the brain, because it can provide information about certain brain functions. In addition, MRI is much better than standard X-rays at showing areas of the brain close to the skull and detecting changes in the brain associated with neurological diseases. In this study researchers will use MRI to gather information about the processes that control human movement and sensory processing.

The purpose of the study is to investigate how the brain is activated when remembering, thinking, or recognizing objects. Researchers would like to determine what happens to brain functions when patients have trouble remembering, thinking, or recognizing objects following the start of disorders in the brain and nervous system. In addition, this study will investigate the processes of motor control in healthy volunteers and patients with disease.

Condition
Cerebrovascular Disorder
Healthy
Movement Disorder
Nervous System Disease
Spinal Cord Injury


MEDLINEplusÂ*related topics:Â*Â*MovementÂ*Disorders;Â*Â* NeurologicÂ*DiseasesÂ*(General);Â*Â* SpinalÂ*CordÂ*Injuries;Â*Â* Stroke

Study Type:Â*Natural History


Official Title:Â*Central Nervous System Motor and Cognitive Processes: Nuclear Magnetic Resonance Imaging at 1.5 to 4 Tesla

Further Study Details:Â*

The main purpose of the studies presented in this protocol is to investigate the physiology of motor control in health as well as the pathophysiological modifications taking place during disease. Patients and normal volunteers will be scanned at rest and during different tasks, either while making repetitive movements or undergoing sensory stimulation. These studies should provide new insight concerning the processes that control human movement and sensory processing. The studies described in this protocol will be conducted by systems operating on 1.5 Tesla up to 4 Tesla, including a system at 3 Tesla which is going to be installed in near future.

Eligibility

Genders Eligible for Study:Â* Both

Criteria

Patients with movement disorder and normal volunteers.


Location and Contact Information

Maryland
National Institute of Neurological Disorders and Stroke (NINDS),Â*9000 Rockville Pike Â* Bethesda, Â* Maryland, Â* 20892, Â* United States;Â*Recruiting

Â*Â* PRPL Â*1-800-411-1222Â* Â* prpl@mail.cc.nih.govÂ*

More Information

Detailed Web Page

Publications

Sadato. 1997. Frequency-dependent changes of regional cerebral blood flow during finger movements: functional MRI compared to PET, J Cereb Blood Flow Metab, Vol. 17, p. 670

Karni. 1995. Functional MRI evidence for adult motor cortex plasticity during motor skill learning, Nature, Vol. 377, p. 155

Aquilonius. 1991. What has PET told us about Parkinson's Disease?, Acta Neurol Scand Suppl, Vol. 136, p. 37

Study ID NumbersÂ* 93-N-0010
NLM IdentifierÂ* NCT00001361

Date study startedÂ*October 28, 1992
Record last reviewedÂ* September 20, 2000
Last UpdatedÂ* September 20, 2000

[This message was edited by Wise Young on September 27, 2001 at 01:13 PM.]