Improving recovery from spinal cord injury

manouli · 06-10-2010, 08:42 AM

Public release date: 9-Jun-2010
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Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions

Improving recovery from spinal cord injury

Once damaged, nerves in the spinal cord normally cannot grow back and the only drug approved for treating these injuries does not enable nerve regrowth. Publishing online this week in the Early Edition of the Proceedings of the National Academy of Sciences, researchers at the Johns Hopkins University School of Medicine show that treating injured rat spinal cords with an enzyme, sialidase, improves nerve regrowth, motor recovery and nervous system function.

"This is the first functional study showing behavioral improvement below a spinal cord injury by the delivery of sialidase," says Ronald Schnaar, Ph.D., a professor of pharmacology and molecular sciences at Johns Hopkins. "Sialidase has properties that are appealing from the human drug development point of view."

Sialidase is a bacterial enzyme that removes specific chemical groups found on the surface of nerve cells. The chemical groups normally function to stablize the cells, but also act to prevent nerve regeneration.

read...

http://www.eurekalert.org/pub_releas...-irf060910.php

KIM · 06-10-2010, 09:47 AM

Sialidase has been around since 2006 at least, some more results should have been seen.

Eric.S · 06-10-2010, 05:34 PM

Quote:

Originally Posted by KIM

Sialidase has been around since 2006 at least, some more results should have been seen.

have they been using it in sci?

06-10-2010, 08:42 AM	#1
manouli Senior Member Join Date: Nov 2004 Location: florida Posts: 9,339	Improving recovery from spinal cord injury Public release date: 9-Jun-2010 [ Print \| E-mail \| Share ] [ Close Window ] Contact: Audrey Huang audrey@jhmi.edu 410-614-5105 Johns Hopkins Medical Institutions Improving recovery from spinal cord injury Once damaged, nerves in the spinal cord normally cannot grow back and the only drug approved for treating these injuries does not enable nerve regrowth. Publishing online this week in the Early Edition of the Proceedings of the National Academy of Sciences, researchers at the Johns Hopkins University School of Medicine show that treating injured rat spinal cords with an enzyme, sialidase, improves nerve regrowth, motor recovery and nervous system function. "This is the first functional study showing behavioral improvement below a spinal cord injury by the delivery of sialidase," says Ronald Schnaar, Ph.D., a professor of pharmacology and molecular sciences at Johns Hopkins. "Sialidase has properties that are appealing from the human drug development point of view." Sialidase is a bacterial enzyme that removes specific chemical groups found on the surface of nerve cells. The chemical groups normally function to stablize the cells, but also act to prevent nerve regeneration. read... http://www.eurekalert.org/pub_releas...-irf060910.php

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06-10-2010, 09:47 AM	#2
KIM Senior Member Join Date: Jul 2001 Location: SPAIN Posts: 835	Sialidase has been around since 2006 at least, some more results should have been seen.