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Thread: researchblog

  1. #231
    "Also, we are learning that there are many axons from various brainstem reticular (a more primitive system of circuits that support many basic functions) and propriospinal systems ( a multisegmental system of axons) that repeatedly cross the midline below the lesion. They can be a source for remyelination strategies as well as an anatomical source for sprouting strategies because they seem to have a strong potential to regenerate on their own." J.Silver
    ? This "CAN" here in an assertive form or it's rather a provisional diagnosis?

    "I just want to mention that this [chondroitinase] is not just about breathing. It's about everything." J.Silver
    ? Everything-everything?

    Quote:
    Originally Posted by kivi66
    "CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination" http://www.ncbi.nlm.nih.gov/pubmed/20569695
    Abstract
    After central nervous system (CNS) demyelination-such as occurs during multiple sclerosis-there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but also by Schwann cells. The origins of the remyelinating cells have not previously been established. We have used Cre-lox fate mapping in transgenic mice to show that PDGFRA/NG2-expressing glia, a distributed population of stem/progenitor cells in the adult CNS, produce the remyelinating oligodendrocytes and almost all of the Schwann cells in chemically induced demyelinated lesions. In contrast, the great majority of reactive astrocytes in the vicinity of the lesions are derived from preexisting FGFR3-expressing cells, likely to be astrocytes. These data resolve a long-running debate about the origins of the main players in CNS remyelination and reveal a surprising capacity of CNS precursors to generate Schwann cells, which normally develop from the embryonic neural crest and are restricted to the peripheral nervous system.
    Dr.Wise, does the above mean that Schwann cells are capable successefully (in functional meaning) substitute oligodendrocytes in the CNS? Or all this stuff has nothing with functional restoration after sci?
    Dr.Silver, I know, it's not quite a subject you are working on, nevertheless, comment, please, on this,--some thoughts on and vision of.
    ! Jerry, you have an undone homework here.

  2. #232
    Dr.Silver, does Wise's HLA-matching theory as a hurdle for conducting pig trials make sence to you?
    What about your own collaboration with pig-oriented labs?
    Wise is perfoming trials, you are just ctiticise him.
    If you continue with not-replying to me, then your transformation into "stephen davies" has begun.
    Jerry, pigs are your best friends for now. And I am very serious by saying that.

  3. #233
    Kivi66, English may not be your first language but you need to know that you are so hard to understand sometimes.

  4. #234
    Chris, I am hardly understandable for myself too
    And thx for tolerating me, I know it's hard.

  5. #235
    "Looking forward to hearing about the results IN ANIMALS BEFORE we attempt this in people, don't you think? " J.Silver
    Yeah, Jerry, I DO think so. Just provided that by saying "ANIMALS" you mean "SWINES".

  6. #236
    Jerry, if you are serious about converting chronical spinal damage from incurable condition into at least treatable and improvable, you have to replicate your rat-achievement to some not-rodent model.
    Otherwise, this dull and doleful harping will never cease:
    Quote Originally Posted by kivi66 View Post
    "should be investigated further", "It should be studied", "it should be done", "it would be reasonable" Wisy man.
    Wise, you are just one big "Shouldy-Wouldy".

  7. #237
    Quote Originally Posted by kivi66 View Post
    Jerry, if you are serious about converting chronical spinal damage from incurable condition into at least treatable and improvable, you have to replicate your rat-achievement to some not-rodent model.
    Otherwise, this dull and doleful harping will never cease:
    Kivi66 - It's been mentioned many many times here that ISRT are looking to progress the Ch'ase story. Jerry is part of the steering committee for this initiative. You must have seen the project that has been recently funded by ISRT to test Ch'ase in chronic dogs?

    With regards to the peptide, Jerry has mentioned that he's looking for partners to help take that work forward to the next stages.

    Finally, Jerry has also said on here that his relatively small lab does not have the resources for conducting larger animal studies.

    Or are you expecting something else from Jerry? Or are you just playing devils advocate?

    Fly Pelican Fly

  8. #238
    Yeah, Pely, I am just such a "playboy"

  9. #239
    Will Kivi get back his posting priviledges after a period of suspension?
    I agree that at times his insolence was unnecessary, but sometimes he has provided interesting inputs IMO.

    Paolo
    In God we trust; all others bring data. - Edwards Deming

  10. #240
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