Radius Begins Phase II Clinical Trial of BA058 for Osteoporosis

(posted on 20/03/2007)



http://www.lifesciencesworld.com/new.../26542?page=10


CAMBRIDGE, Mass., March 20 /PRNewswire/ — Radius announced today that it has commenced enrollment for a Phase II clinical trial of BA058, the company’s analog of hPTHrP (human parathyroid hormone-related protein). BA058 is being developed for the treatment of osteoporosis in postmenopausal women, and the Phase II dose-finding study is designed to further evaluate the ability of BA058 to build new bone in this population.


“There is a need for a next generation of osteoporosis drugs that build new bone more rapidly and are more convenient for patients to use,” said C. Richard Lyttle, PhD, President and Chief Executive Officer of Radius. “Preclinical and Phase I clinical results with BA058 support its potential to offer these improvements over currently available anabolic therapies, which could result in greater compliance and, ultimately, greater overall benefit to patients.”

PTHrP (parathyroid hormone-related protein) is a critical cytokine for promoting new bone formation, with a role distinct from PTH (parathyroid hormone), which regulates calcium homeostasis and bone resorption.