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Thread: Breakthrough in repairing damage that causes MS

  1. #1
    Senior Member Jeremy's Avatar
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    Breakthrough in repairing damage that causes MS

    09/10/07 - Health section

    Breakthrough in repairing damage that causes MS

    Scientists have developed a radical new drug that could reverse the effects of multiple sclerosis within weeks.

    Researchers at the Mayo Clinic have developed a human antibody administered in a single dose that can repair myelin, the insulating covering of nerves that when damaged can lead to multiple sclerosis.

    The breakthrough will be presented at the American Neurological Association meeting in Washington DC today and the researchers hope a treatment can be developed within years.

    The drug has already been successfully tested on mice and preliminary human trials have begun.

    "The findings could eventually lead to new treatments that could limit permanent disability," said Professor Arthur Warrington, who led the study.

    Multiple sclerosis is the most common disabling neurological condition affecting young adults. Around 85,000 people in Britain have MS. Symptoms range from muscle stiffness and spasms, to speech difficulties and tremors.

    Myelin repair normally occurs spontaneously in healthy humans but with multiple sclerosis and other disorders of the central nervous system the process is very slow or fails altogether.

    The antibody, which was genetically engineered from a single cell, binds to myelin and the surface of cells in the brain and spinal cord, then triggers the cells to begin the repair process, called remyelination.

    The antibody is the first known drug designed to induce repair by acting within the central nervous system on the damaged cells responsible for myelin synthesis.

    "The concept of using natural human antibodies to treat disease of this kind has not yet been tested in humans but these research findings are very promising," said Dr Moses Rodriguez.

    The study used laboratory mouse models of chronic progressive multiple sclerosis in humans.

    Researchers found a small dose equivalent to 5mg in humans of the antibody was needed and took five weeks to work on average.

    As a naturally occurring protein of the immune system, antibodies do not appear to have any side effects, nor are they toxic - even when administered at 4,000 times the minimal effective dose.

    Experts today hailed the discovery but warned that human trials were still some way off.

    Dr Laura Bell of the MS Society said: "Myelin repair is an exciting avenue of research that holds a lot of promise as an MS treatment, which is why we have invested more than £3 million into it at our research centres in Cambridge and Edinburgh.

    "This is an exciting study but it's early days - we'll be keen to see how it works in people with MS."


    Find this story at http://www.dailymail.co.uk/pages/liv...n_page_id=1774
    ©2007 Associated New Media

  2. #2
    If its so promising why do all the warnings say its still far away from the goal?

  3. #3
    Senior Member Schmeky's Avatar
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    Eric,

    I feel there is a very cautious attitude when the CNS is involved.

    Read this report carefully, it states even though this breakthrough is a naturally occurring protein safe at 4000 times the minimum effective dose, human trials are still some ways off.

    Like it or not, bitch and complain, clinical trials, even with something as promising as this, are a long-term slow moving process. I hate it.
    Last edited by Schmeky; 10-09-2007 at 09:22 PM.

  4. #4
    Senior Member DA's Avatar
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    If aliens from space visit Earth and as gift gave us the cures to all. They would withold it. its about the research. they need the disable community to justify the research.

  5. #5
    Wonder which antibody they're referring to.

    The drug has already been successfully tested on mice and preliminary human trials have begun.
    Experts today hailed the discovery but warned that human trials were still some way off.


    Ah, here it is:

    The Mayo Clinic's Arthur Warrington, PhD, and colleagues tested a lab-made antibody called rHIgM22.

    http://www.webmd.com/multiple-sclero...src=RSS_PUBLIC

    Sounds like it would be a good candidate for the FDA's new fast track clinical trials program. Wonder if this could help SCI's suffering from demyelination.
    Last edited by antiquity; 10-09-2007 at 10:56 PM.

  6. #6
    Sounds good.

    A recombinant human monoclonal IgM, rHIgM22, promotes the synthesis of new myelin when used to treat several animal models of demyelination. rHIgM22 binds to myelin and the surface of oligodendrocytes and accumulates at central nervous system lesions in vivo. The minimal dose of monoclonal IgM required to promote remyelination has a direct bearing on the proposed mechanism of action. A dose ranging study using rHIgM22 was performed in mice with chronic virus-induced demyelination, a model of chronic progressive multiple sclerosis. The lowest tested dose of rHIgM22 effective at promoting spinal cord remyelination was a single 500-ng intraperitoneal bolus injection. A time course study of spinal cord repair performed in chronically demyelinated mice revealed that remyelination plateaued by 5 weeks following treatment with rHIgM22...
    http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum

  7. #7

    Multiple Sclerosis Nerve Damage Repaired By Scientists

    Multiple Sclerosis Nerve Damage Repaired By Scientists

    quote:

    "The repair of chronic spinal cord injury is seldom modeled in laboratory studies, but it is an important reality for the treatment of humans. The concept of using natural human antibodies to treat disease of this kind has not yet been tested in humans, but these research findings are very promising," said author, Moses Rodriguez, M.D., a Mayo Clinic neurologist.


    http://www.medicalnewstoday.com/articles/85087.php

  8. #8
    Being a walking quad, im very excited about this!!!!!

  9. #9
    Senior Member DA's Avatar
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    Quote Originally Posted by ineedmyelin
    Being a walking quad, im very excited about this!!!!!
    this is win the lottery news for you and a large percent of sci people. its not toxic at high doses which is the common excuses for sci treatments. the focus now should be to get this to bedside.

  10. #10
    I know and have worked with Moses Rodriguez. I have the highest respect for his work and his science. This is a very important discovery.

    It is more than just the discovery of a natural IgM antibody that stimulates remyelination. This is one of the so-called germ cell line antibody, an antibody that is coded in the genome, an antibody that acts as a signal for certain biological activities such as remyelination.

    Wise.

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