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Thread: Stephen Davies Update

  1. #1051
    Quote Originally Posted by George78 View Post
    Don't you think we should update the Clinical Trials sticky with a big warning refering to Dr. Davies recommandations?..

    I think that the discovery of the team of Dr. Davies is a major milestone, it could give an explanation of 20 years of unsuccesfull neural stem cells transplantations in the CNS..
    G78
    George,

    Geron, Stem Cell Inc., ChinaSCINet are now carrying out clinical trials transplanting cells into the spinal cord of people. In the case of Geron, they are transplanting oligodendroglial progenitor cells derived from human embryonic stem cells. Stem Cell Inc. is transplanting neural stem cells that include astrocytes into the spinal cord of people. ChinaSCINet is transplanting HLA-matched umbilical cord blood cells into the spinal cord. I know of at least half a dozen clinics around the world that have transplanted autologous bone marrow mesenchymal stem and stromal cells intravenously, intra-arterially, or intrathecally to the spinal cord.

    Although some of the these transplants have been associated with transient (2-3 weeks) increase of neuropathic pain, most of these have not caused significant amounts of long lasting neuropathic pain or allodynia. In some of the cases, the transient onset of neuropathic pain seems to precede the recovery of sensory function in the patients. I would think that human clinical experience suggests that many types of cells can be transplanted into the spinal cord without the kinds of complications that Dr. Davies is talking about. It is important that limited animal experience not be used to stop clinical trials from going forward. If, for example, a cell transplant were to cause the kind of complications that Dr. Davies is talking about, one should be cautious about going forward with further clinical studies.

    It is not true that 20 years of experience with stem cell transplants has been completely negative. In the case of olfactory ensheathing glial cells, a uniform experience of over half a dozen groups suggest that the cells restore sensory function to several dermatomes below the injury site. Motor recovery is limited. We shall soon see if the current ciinical trials show signficant functional benefits. It is not a good idea to block progress in clinical trials based on limited animal data.

    The sparse motor recovery can be for many reasons besides the one that Dr. Davies is talking about. For example, most of the groups used non-HLA matched fetal allografts that are probably rejected within a few weeks after transplantation, leading short-term and limited recovery. Another reason for lack of recovery is that few of the groups have coupled their cell transplantation with intensive motor training. Evidence is accumulating that motor recovery requires training. Finally, there is an open question whether any single cell transplant would really do the job of allowing axons to grow across the injury site and extend all the way up and down the spinal cord. The transplants may have to be coupled with therapies such as chondroitinase, lithium, nogo antibodies, cethrin, etc. to yield signicant long distance regeneration for chronic spinal cord injury.

    Wise.
    Last edited by Wise Young; 05-06-2011 at 09:43 AM.

  2. #1052
    Senior Member Schmeky's Avatar
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    I would think that human clinical experience suggests that many types of cells can be transplanted into the spinal cord without the kinds of complications that Dr. Davies is talking about. It is important that limited animal experience not be used to stop clinical trials from going forward. If, for example, a cell transplant were to cause the kind of complications that Dr. Davies is talking about, one should be cautious about going forward with further clinical studies.
    It is my belief Davies is comfortable in the lab . . . . . . .

  3. #1053
    Quote Originally Posted by Wise Young View Post
    The transplants may have to be coupled with therapies such as chondroitinase, lithium, nogo antibodies, cethrin, etc. to yield signicant long distance regeneration for chronic spinal cord injury. Wise.
    And, potentially Decorin to eliminate the scar problem...

  4. #1054
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    Grammy which stem cells Davies will be using and when he plans to start trials?

    Dr Wise if ur trials recover bladder bowel and sexual function in patients then do u think this treatment can work for conus injuries with bladder bowel and sexual problems?

  5. #1055
    Jawaid
    i am with you on bladder bowel and sexual problems? If we could get that back it would be nice to start with. and let the walking to come after ? well not that long after but you know what i main
    AS I SIT HERE IN MY CHAIR . I LOOK OUT UPON THE GROUND .I WONDER WILL I EVER GET UP AND WALK A ROUND ??


    http://justadollarplease.org

  6. #1056
    Senior Member KIM's Avatar
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    When ever he can he will.

  7. #1057
    Colorado Public Radio interview with Dr. Davies on 4/11/2011.

    Here is the original link:
    http://www.cpr.org/#load_article|CU_...s_Breakthrough

    The mp3 is attached just in the original link is no longer available.

  8. #1058
    According to the interview remarks, it appears they are putting together information and coordinating future international clinical trials (China, Europe...) This is wonderful. Full steam ahead on getting this valuable research into human trials. Thanks litespeed4, for posting the radio webcast so we could all hear the interview.

  9. #1059
    Senior Member 0xSquidy's Avatar
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    Quote Originally Posted by litespeed4 View Post
    Colorado Public Radio interview with Dr. Davies on 4/11/2011.

    Here is the original link:
    http://www.cpr.org/#load_article|CU_...s_Breakthrough

    The mp3 is attached just in the original link is no longer available.
    Thanks for sharing!
    Don't ask what clinical trials can do for you, ask what you can do for clinical trials.

    Fenexy: Proyecto Volver a Caminar

    http://www.fenexy.org (soon in english too)

  10. #1060
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    Sweden is collaborating with Craig Hospital in Colorado, on some cell systems on SCI repair, if I am not too lazy remembering, stuff explained by the Swedes.

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