Page 1 of 19 1234567891011 ... LastLast
Results 1 to 10 of 184

Thread: a cure ?when and by who?

Hybrid View

Previous Post Previous Post   Next Post Next Post
  1. #1
    Banned adi chicago's Avatar
    Join Date
    Jun 2006
    Location
    near dracula castle
    Posts
    9,508

    a cure ?when and by who?

    a cure for sci ?when and by who?yours opinions please.
    • Dum spiro, spero.
      • Translation: "As long as I breathe, I hope."

  2. #2
    Senior Member Robynbird569's Avatar
    Join Date
    Jan 2006
    Location
    Lake Isabella Mi
    Posts
    706
    I dont know by who, but I would be so happy if by the time my 8 year old daughter gets to high school she would be able to dance at her high school prom.


    Stay safe my son. See you around thanksgiving!

  3. #3
    partial, less than 5 years away - borgens
    significant, 5+ years away - have no idea

  4. #4
    Senior Member redbandit's Avatar
    Join Date
    Jan 2006
    Location
    North Carolina
    Posts
    393
    I agree somewhat with antiquity:

    partial = 5 years from Geron, Davies, ChinaSCINet, others
    significant = 20 years, who knows

  5. #5
    Quote Originally Posted by redbandit
    I agree somewhat with antiquity:

    partial = 5 years from Geron, Davies, ChinaSCINet, others
    significant = 20 years, who knows
    Also somewhat agree.

    partial for acute = 5 years, Geron or ChinaSCINet.

    any recovery at all for chronic = proof of concept in 10 years from
    whoever has published the results of their acute clinical trials first.

  6. #6
    I was reading an article, stating that some scientists might have found out the protein, that stop the nerve axons in the brain and spinal cord from regenerating. I'm not holding my breath.

  7. #7
    Senior Member Max's Avatar
    Join Date
    Jul 2001
    Location
    Montreal,Province of Quebec, CANADA
    Posts
    15,036

    Cool

    Quote Originally Posted by ac06
    I was reading an article, stating that some scientists might have found out the protein, that stop the nerve axons in the brain and spinal cord from regenerating. I'm not holding my breath.
    Please Breethe! Why would they look for protein, "that stop the nerve axons from regenerating"???

    It makes no sense

  8. #8
    Quote Originally Posted by Max
    Please Breethe! Why would they look for protein, "that stop the nerve axons from regenerating"???

    It makes no sense
    Max,

    Such proteins are present in the spinal cord. They include Nogo, chondroitin-6-sulfate-proteoglycan, and several others. Binding of these proteins or the axonal receptors to such proteins (Nogo receptor blockers or the intracellular messengers for such receptors... by cethrin, for example) has been shown to stimulate regeneration.

    This is one of the most important components to the cure for spinal cord injury. Let me remind people of the developments.

    • Nogo. An antibody to Nogo was identified in 1990 by Martin Schwab. Nogo itself was identified in 2000. The Nogo receptor was identified in 2001 by Stephen Strittmatter. Rho was soon found found to be the intracellular messenger mediating the growth inhibitory effects of the Nogo receptor. Lisa McKerracher proposed that a bacterial toxin called C3 that blocks rho would allow regeneration to occur. She developed a form of C3 that penetrates into axons, called it cethrin and formed a company (Bioaxone) to test it in patients. They just completed a phase 1 trial showing that cethrin improves function when injected into the spinal cords of patients within 2 weeks after injury. The rights to cethrin has been bought by Boston Life Science and they are planning to continue the clinical trials.

    • Chondroitinase. In 2001, Liz Bradbury reported the chondroitinase stimulates regeneration in the spinal cord when it is injected into the spinal cord of rats. Silver, et al. (2006) recently found that chondroitinase allows regrowth of axons back into the spinal cord, through peripheral nerve bridge, restoring function in rats with a C3 hemisection. Acorda Therapeutics has the license for chondroitinase and is trying to raise funds to take it to clinical trial.

    Wise.

  9. #9
    Senior Member
    Join Date
    Sep 2001
    Location
    New York USA
    Posts
    291
    I gave up on that question last year on my 10th anniversary. I need it by 2012 and that's when my drivers license expires. Personally I wish it would happen sooner, but not holding my breath. If anybody could find a crystal ball what can answer this question would love to hear it. Just get ready for all the negative answers,

  10. #10
    Senior Member Kratos's Avatar
    Join Date
    Apr 2007
    Location
    Lat:+46,034635 Long:+16,619310 Croatia
    Posts
    782
    a cure ?when and by who? partial cure yes, but cure cure in our lifetime no no...

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •