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Thread: Viagra & neurogenesis?

  1. #1

    Question Viagra & neurogenesis?

    Does viagra really spur brain neurogenesis? and what about spinal cord neurogenesis?

  2. #2
    Quote Originally Posted by drnader
    Does viagra really spur brain neurogenesis? and what about spinal cord neurogenesis?
    Not to my knowledge. Where did you hear this? Wise.

  3. #3
    If it did, I'd be walking by now.
    "Life is about how you
    respond to not only the
    challenges you're dealt but
    the challenges you seek...If
    you have no goals, no
    mountains to climb, your
    soul dies".~Liz Fordred

  4. #4
    Quote Originally Posted by Wise Young
    Not to my knowledge. Where did you hear this? Wise.
    http://stroke.ahajournals.org/cgi/co...act/33/11/2675

  5. #5
    Antiquity,

    Thanks. Many drugs have been reported to increase hippocampal neurogenesis. In a recent Science article, Scharfman & Hen asked, "Is More Neurogenesis Always Better". They pointed out that many drugs have been reported to increase neurogenesis. http://www.sciencemag.org/cgi/content/full/315/5810/336


    Antidepressants (19, 20, 22)
    Tricyclic antidepressants
    Selective serotonin reuptake inhibitors
    Mood stabilizers (22)
    Lithium
    Valproic acid
    Cognitive enhancers (23)
    Galantamine
    Memantine
    Anesthetics (24)
    Ketamine
    Steroids (1, 22)
    Estradiol
    Dehydroepiandrosterone
    Other (22)
    Rolipram
    Statins
    Sildenafil (Viagra)

    Incidentally, running enhances neurogenesis, learning, and long-term potentiation in mice (Source).

    Given the large number of people here who have taken Viagra, has anybody seen improved long-term functional improvement associated with taking of that drug? Has it improved the memory, cognition, and intelligence of the people?

    The study by Chopp, et al. you cited showed that oral sildenafil (2-5 mg/kg) given 2 or 24 hour after induction of stroke by a middle cerebral artery occlusion did not change the infarct site at 25 days bu the rats had enhanced neurological recovery, increased neurogenesis in the ipsilateral subventricular zone and striatum. The rats treated at 24 hours after stroke had significantly increased angiogenesis and capillary formation in the ischemic boundaries.

    The mechanisms of these effects, however, are unclear. In a more recent study this year, the same group reported that rats showed improved cerebral blood flow after embolic stroke when treated with Sildenafil. http://www.pubmedcentral.nih.gov/art...?artid=1885791

    Wise.
    Last edited by Wise Young; 07-16-2007 at 09:31 AM.

  6. #6

  7. #7
    Quote Originally Posted by Wise Young
    Antiquity,

    Thanks. Many drugs have been reported to increase hippocampal neurogenesis. In a recent Science article, Scharfman & Hen asked, "Is More Neurogenesis Always Better". They pointed out that many drugs have been reported to increase neurogenesis. http://www.sciencemag.org/cgi/content/full/315/5810/336


    Antidepressants (19, 20, 22)
    Tricyclic antidepressants
    Selective serotonin reuptake inhibitors
    Mood stabilizers (22)
    Lithium
    Valproic acid
    Cognitive enhancers (23)
    Galantamine
    Memantine
    Anesthetics (24)
    Ketamine
    Steroids (1, 22)
    Estradiol
    Dehydroepiandrosterone
    Other (22)
    Rolipram
    Statins
    Sildenafil (Viagra)

    Incidentally, running enhances neurogenesis, learning, and long-term potentiation in mice (Source).

    Given the large number of people here who have taken Viagra, has anybody seen improved long-term functional improvement associated with taking of that drug? Has it improved the memory, cognition, and intelligence of the people?

    The study by Chopp, et al. you cited showed that oral sildenafil (2-5 mg/kg) given 2 or 24 hour after induction of stroke by a middle cerebral artery occlusion did not change the infarct site at 25 days bu the rats had enhanced neurological recovery, increased neurogenesis in the ipsilateral subventricular zone and striatum. The rats treated at 24 hours after stroke had significantly increased angiogenesis and capillary formation in the ischemic boundaries.

    The mechanisms of these effects, however, are unclear. In a more recent study this year, the same group reported that rats showed improved cerebral blood flow after embolic stroke when treated with Sildenafil. http://www.pubmedcentral.nih.gov/art...?artid=1885791

    Wise.
    That'll be interesting to find out. I'll link this to R/S.

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