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Thread: Breakthrough in multiple sclerosis research

  1. #21

    Drug that may reverse Multiple Sclerosis hailed as a breakthrough

    Drug that may reverse Multiple Sclerosis hailed as a breakthrough

    Thursday, 23 October 2008

    Multiple Sclerosis sufferers across Northern Ireland were given fresh hope last night after scientists may have found a drug with the unprecedented power to halt advancement of the condition — and reverse damage already done.

    The discovery is being hailed as the biggest advance against the debilitating neurological condition for more than a decade and could prove effective against other, similar diseases. The MS Society said it was "delighted" by the results.

    Scientists believe the drug, alemtuzumab, may also be effective in other conditions. Further studies are under way into its use in autoimmune conditions such as rhemumatoid arthritis, in which the immune system attacks itself, and in transplant surgery.

    Alemtuzumab was developed 30 years ago by researchers at the University of Cambridge and is an established treatment for leukaemia. It was the first monoclonal antibody – a type of immune system booster – given to humans and heralded a new era of powerful medical treatments. Its creator, Cesar Milstein, was awarded a Nobel Prize in 1984.


  2. #22
    I saw Tony Johnstone (the golfer mentioned in the article) on the news last night and his story is certainly compelling evidence that the treatment has worked for him. Very good news for MS sufferers in the early stages.

  3. #23
    British Researchers Make Major Multiple Sclerosis Breakthrough
    By Tom Rivers
    23 October 2008

    Rivers report - Download (MP3)
    Rivers report - Listen (MP3)

    British scientists have found a drug used to fight leukemia that appears to stop multiple sclerosis in its early stages and restore lost function to patients. Although still in the clinical trial phase, it is being called by some, the most promising and most significant MS treatment yet discovered. For VOA, Tom Rivers reports from London.

    The three-year study conducted by Cambridge University researchers found for the first time a treatment that showed long-term multiple sclerosis disability improvement.


  4. #24
    This is an exciting development. It prevents progression. Now, what we need are treatments that reverses neurological losses. Wise.

  5. #25
    what about this?

    can this restore spinal cord?

  6. #26
    Stem-cell therapy reduces symptoms of multiple sclerosis
    3:30 PM, January 29, 2009

    Infusing multiple sclerosis patients with their own immune stem cells appears to help the immune system "reset" itself and fight off the disease, according to a study that will be published online Friday in the Lancet Neurology.

    The study, an early-phase research project involving only 21 patients, is similar to other experiments in which a patient's own stem cells are used to treat autoimmune diseases. The treatment, called autologous non-myeloablative haematopoietic stem-cell transplantation, has also shown promising results in people with lupus and diabetes.

    In the new study, Dr. Richard Burt of Northwestern University's Feinberg School of Medicine, selected people ages 20 to 53 who had early-stage MS (they had been diagnosed an average of five years) and who had not responded to at least six months of treatment with interferon beta, the standard treatment for the disease.


  7. #27
    MS attacks the brain, said one researcher. 'After the procedure, it doesn't do that any more.'

    Bone marrow stem cells prove effective in treating MS

    A Northwestern University of Chicago study using adult stem cells to treat patients suffering from early onset multiple sclerosis has lead to an improvement in the condition of 17 of the 21 patients, with 16 patients demonstrating no relapse in their condition three years after receiving the treatment.

    Patients in the study were in what is commonly referred to as the first stage of the autoimmune disease, in which their symptoms periodically flare up and then subside.

    According to Bloomberg, the patients' blood-forming stem cells were extracted, and then chemotherapy drugs were used to kill the patient’s immune cells within their bone marrow.

    After the chemotherapy treatment, the patient’s hematopoietic cells were returned to the body. A Northwestern University report on the study said this transplantation process resets the patient’s immune system.


  8. #28

    Thumbs up

    my friends this is great news yeah?

    College Student With Multiple Sclerosis Symptom-Free After Stem-Cell Treatment
    Monday, February 23, 2009

    Edwin McClure, a Virginia Commonwealth University advertising graduate student, says a stem-cell study he participated in appears to have cured his multiple sclerosis symptoms.

    McClure started showing symptoms of MS in 2000 when he was a senior in high school.

    Although he initially thought it was just a cold, he knew the condition was more serious when his vision began blurring.

    "It was like someone turning down the dimmer switch," McClure said.

    When his neurologist told him he was showing the symptoms of MS, he was surprised and confused."

    It threw me for a loop," McClure said. "This is a disease that typically hits 40-year-old white women and I'm like, 'I'm an 18-year-old black male.' Somebody didn't get the memo."


  9. #29
    Easing the pain of MS: Hilton Head Island resident Vita Johnson is looking to stem cell treatment in China for relief from multiple sclerosis ( )

    Mar 24, 2009 (The Island Packet - McClatchy-Tribune Information Services via COMTEX) -- Sometimes, the pain is manageable. Vita Johnson can operate her mechanical wheelchair, but her back and right arm are almost always in pain, like the muscles are constantly tense. Other times, the pain is unbearable. All she can do is stay in her darkened bedroom and cry.
    She used to jog, lift weights, swim and jump out of airplanes for fun. But multiple sclerosis has reduced her body to the point where she needs help just to go to the bathroom.

    She wants to be better, but none of her treatments have stopped the MS, a disease that attacks the central nervous system. She sees hope, but it's halfway around the world.

    Johnson is raising money to go to China to receive injections of stem cells, a treatment that she hopes will improve her condition. She'd like to do it in her own country, but it's not permitted in the United States.

    Stem cell therapy has been hotly debated. Clinics in Costa Rica, China and elsewhere offer the treatments for a variety of afflictions, from cerebral palsy to spinal cord injuries. Some of these clinics' Web sites feature stories of the wheelchair-bound who take their first steps again, the blind who can make out shapes and letters.


    But in the United States, skepticism mixes with hope. Advocates of stem cell research say one day stem cell treatments may prove beneficial for Vita and other MS suffers. But the evidence isn't there yet. The National Multiple Sclerosis Society issued a statement last month encouraging research of stem cells in clinical tests.


  10. #30
    United Spinal Association Reports Positive Results of Stem Cell Transplantation to Treat Multiple Sclerosis: Study May be Key to Unlocking a Cure

    NEW YORK, May 8 /PRNewswire-USNewswire/ -- An article published in the Summer 2009 edition of Multiple Sclerosis Quarterly Report, a joint publication of United Spinal Association ( and the North American Research Committee on Multiple Sclerosis (NARCOMS), highlights the positive initial results of patients who have improving neurologic function after receiving a stem cell transplant, despite no longer taking any MS medications.

    The results are reported in a National Institutes of Health (NIH)-sponsored study called HALT-MS to confirm whether high-dose immunosuppression followed by autologous stem cell transplantation will prevent MS attacks in patients who are not responding to available treatment options and ultimately protect against the degeneration of nerve fibers.


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