Neural stem cells can differentiate into neurons, astrocytes, and oligodendrocytes in the mammalian central nervous system, but the molecular mechanisms that regulate the differentiation are not yet well understood. Insulin-like growth factor 1 (IGF-1) plays important roles during neuronal development. We examined the possibility that the IGF-1/leukemia-associated RhoGEF (LARG) pathway affects the differentiation of neural stem cells into oligodendrocytes. Characterization of cells positive for both IGF-1 receptor ? and LARG in the subventricular zone during neuronal development suggests that IGF-1/LARG signaling is involved in oligodendrocyte differentiation from multipotent neural progenitor cells.

J Nippon Med Sch 2007; 74: 2-3

Correspondence to
Nobuchika Suzuki, Department of Bioregulation, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki, Kanagawa 211-8533, Japan