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Thread: St. Johns Wort?

  1. #1

    St. Johns Wort?

    Does anyone take this?

    "Learn from yesterday, live for today, hope for tomorrow"
    ~ Anon

  2. #2
    Moderator Obieone's Avatar
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    Hey Emi ... yes I take it regularly ... depression runs in our family so I take it as a prophylatic supplement (just in case) ! But I really do believe I am "clinically" depressed from time to time although I've never actually been diagnosed .... it gets me over the hump !! It's my understanding they have been using St.John's Wort in many countries in Europe for years!!

    Obieone
    P.S. If you start taking it regularly be sure to tell your doctor and becareful when you're in the sun ... you will burn more easily for some reason .....

  3. #3
    Originally posted by Emi:

    Does anyone take this?

    "Learn from yesterday, live for today, hope for tomorrow"
    ~ Anon
    I know a lot of people who take it. But if you want to try, talk with a doctor. A lot of medicine is influenced by the wort, birth controll pills, meds for high bloodpressure a.s.o

    TH 12 incomplete 12-12-69.

  4. #4
    yes i take it quite a bit, i find it makes me feel a little better

  5. #5
    Emi -- I am in agreement with everyone else. Please talk to your doctor before starting this supplement. It definitely can interfere with some prescription medications. PLG

  6. #6
    Originally posted by SCI-Nurse:

    Emi -- I am in agreement with everyone else. Please talk to your doctor before starting this supplement. It definitely can interfere with some prescription medications. PLG
    I would if I took any perscriptions!

    "Learn from yesterday, live for today, hope for tomorrow"
    ~ Anon

  7. #7
    It's true, St. Johns Wort is relatively
    innocous. The biggest side effect (when taking as directed) is hightened sensitivity to sunlight exposure, ie you will burn quicker.

    I used this with Kava Kava until it was discovered that Kava Kava can effect liver function. The fact was that nothing over the counter for me was going to cut it, so I went on paroxithine (sp?)

    Joe

  8. #8
    Here is some good information about this. Note the many possible drug-drug interactions:

    St. John's Wort

    What other names is the product known by?
    Amber, Amber Touch-and-Heal, Demon Chaser, Fuga Daemonum, Goatweed, Hardhay, Hypereikon, Hyperici Herba, Hypericum, Johns Wort, Klamath Weed, Millepertuis, Rosin Rose, Saint Johns Wort, Saint John's Wort, Saynt Johannes Wort, SJW, St Johns Wort, St John's Wort, Tipton Weed.

    What is it?
    St. John's wort is an herb. Its flowers and leaves are used to make medicine.

    Is it Effective?
    Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

    The effectiveness ratings for ST. JOHN'S WORT are as follows: Likely Effective for...
    Mild to moderate depression. It might not be as effective for more severe cases of depression.

    Possibly Effective for...
    Anxiety.

    Possibly Ineffective for...
    Hepatitis C Virus (HCV) infection.
    HIV/AIDS.
    Pain conditions related to diabetes (polyneuropathy).

    Insufficient Evidence to Rate Effectiveness for...
    Stomach upset, bruises, skin conditions, migraine headache, nerve pain, sciatica, excitability, muscle pain, cancer, obsessive compulsive disorder (OCD), seasonal affective disorder (SAD), premenstrual syndrome (PMS), attention deficit-hyperactivity disorder (ADHD), and other conditions.

    How does it work?
    For a long time, investigators thought a chemical in St. John's wort called hypericin was responsible for its effects against depression. More recent information suggests another chemical, hyperforin, may play a larger role in depression. Hypericin and hyperforin act on chemical messengers in the nervous system that regulate mood.

    Are there safety concerns?
    St. John's wort is safe for most people when used short-term. It can cause some side effects such as insomnia, vivid dreams, restlessness, anxiety, irritability, stomach upset, fatigue, dry mouth, dizziness, headache, and tingling.

    Do not take St. John's wort for more than two months without medical supervision.

    St. John's wort can cause skin to become extra sensitive to the sun. Wear sunblock outside, especially if you are light-skinned.

    Do not use St. John's wort if:
    You are pregnant or breast-feeding.
    You are trying to get pregnant or father a child.
    You have bipolar disorder.
    You have schizophrenia.
    You have Alzheimer's disease.

    Are there any interactions with medications?
    Aminolevulinic acid ...Aminolevulinic acid can make your skin sensitive to the sunlight. St. John's wort might also increase your sensitivity to sunlight. Taking St. John's wort along with aminolevulinic acid might increase the chances of sunburn, blistering or rashes on areas of skin exposed to sunlight. Be sure to wear sunblock and protective clothing when spending time in the sun.
    Alprazolam (Xanax) ...Alprazolam (Xanax) is commonly used for anxiety. The body breaks down alprazolam (Xanax) to get rid of it. St. John's wort can increase how fast the body gets rid of alprazolam (Xanax). Taking St. John's wort along with alprazolam (Xanax) might decrease the effectiveness of alprazolam (Xanax).
    Amitriptyline (Elavil) ...The body breaks down amitriptyline (Elavil) to get rid of it. St. John's wort can increase how quickly the body gets rid of some medications. St. John's wort might decrease the effectiveness of amitriptyline (Elavil) by increasing how quickly the body breaks down amitriptyline (Elavil).
    Birth control pills (Contraceptive drugs) ...Some birth control pills contain estrogen. The body breaks down the estrogen in birth control pills to get rid of it. St. John's wort might increase the break-down estrogen. Taking St. John's wort along with birth control pills might decrease the effectiveness of birth control pills. If you take birth control pills along with St. John's wort, use an additional form of birth control such as a condom.
    Some birth control pills include ethinyl estradiol and levonorgestrel (Triphasil), ethinyl estradiol and norethindrone (Ortho-Novum 1/35, Ortho-Novum 7/7/7), and others.
    Cyclosporine (Neoral, Sandimmune) ...The body breaks down cyclosporine (Neoral, Sandimmune) to get rid of it. St. John's wort might increase how quickly the body breaks down cyclosporine (Neoral, Sandimmune). By increasing the breakdown of cyclosporine (Neoral, Sandimmune) St. John's wort might decrease the effectiveness of cyclosporine (Neoral, Sandimmune). Do not take St. John's wort if you are taking cyclosporine (Neoral, Sandimmune).
    Dextromethorphan (Robitussin DM, and others) ...St. John's wort can affect a brain chemical called serotonin. Dextromethorphan (Robitussin DM, others) can also affect serotonin. Taking St. John's wort along with dextromethorphan (Robitussin DM, others) might cause too much serotonin in the brain and serious side effects including heart problems, shivering, and anxiety. Do not take St. John's wort if you are taking dextromethorphan (Robitussin DM, and others).
    Digoxin (Lanoxin) ...Digoxin (Lanoxin) helps the heart beat more strongly. St. John's wort might decrease how much digoxin (Lanoxin) the body absorbs. By decreasing how much digoxin (Lanoxin) the body absorbs St. John's wort might decrease the effects of digoxin (Lanoxin).
    Fenfluramine (Pondimin) ...Fenfluramine (Pondimin) increases a chemical in the brain. This chemical is called serotonin. St. John's wort also increases serotonin. Taking fenfluramine with St. John's wort might cause there to be too much serotonin. This could cause serious side effects including heart problems, shivering, and anxiety.
    Fexofenadine (Allegra) ...The body breaks down fexofenadine (Allegra) to get rid of it. St. John's wort might decrease how quickly the body gets rid of fexofenadine. This could cause fexofenadine (Allegra) to stay in the body too long. This could lead to increased effects and side effects of fexofenadine (Allegra).
    Imatinib (Gleevec) ...The body breaks down Imatinib to get rig of it. St. John's wort might increase how quickly the body gets rid of Imatinib (Gleevec). Taking St. John's wort along with imatinib (Gleevec) might decrease the effectiveness of imatinib (Gleevec). Do not take St. John's wort if you are taking Imatinib (Gleevec).
    Irinotecan (Camptosar) ...Irinotecan (Camptosar) is used to treat cancer. The body breaks down irinotecan (Camptosar) to get rid of it. St. John's wort might increase how fast the body breaks down irinotecan (Camptosar) and decrease the effectiveness of irinotecan (Camptosar).
    Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) ...Some medications are changed and broken down by the liver.
    St. John's wort might increase how quickly the liver breaks down some medications. Taking St. John's wort along with some medications that are changed by the liver can decrease the effectiveness of some medications. Before taking St. John's wort talk to your healthcare provider if you take any medications that are changed by the liver.
    Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), zileuton (Zyflo), zolmitriptan (Zomig), and others.
    Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) ...Some medications are changed and broken down by the liver.
    St. John's wort might increase how quickly the liver breaks down some medications. Taking St. John's wort along with some medications that are broken down by the liver can decrease the effectiveness of your medication. Before taking St. John's wort talk to your healthcare provider if you take any medications that are changed by the liver.
    Some medications that are changed by the liver include amitriptyline (Elavil), diazepam (Valium), zileuton (Zyflo), celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), and others.
    Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) ...Some medications are changed and broken down by the liver.
    St. John's wort might increase how quickly the liver breaks down some medications. Taking St. John's wort along with some medications that are broken down by the liver can decrease the effectiveness of some medications. Before taking St. John's wort talk to your healthcare provider if you are taking any medications that are changed by the liver.
    Some medications changed by this liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.
    Medications for depression (Antidepressant drugs) ...St. John's wort increases a brain chemical called serotonin. Some medications for depression also increase the brain chemical serotonin. Taking St. John's wort along with these medications for depression might increase serotonin too much and cause serious side effects including heart problems, shivering, and anxiety. Do not take St. John's wort if you are taking medications for depression.
    Some of these medications for depression include fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Tofranil), and others.
    Medications for depression (MAOIs) ...St. John's wort increases a chemical in the brain. This chemical is called serotonin. Some medications used for depression also increase serotonin. Taking St. John's wort with these medications used for depression might cause there to be too much serotonin. This could cause serious side effects including heart problems, shivering, and anxiety.
    Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.
    Medications that increase sensitivity to sunlight (Photosensitizing drugs) ...Some medications can increase sensitivity to sunlight. St. John's Wort might also increase your sensitivity to sunlight. Taking St. John's wort along with medication that increase sensitivity to sunlight could increase the chances of sunburn, blistering or rashes on areas of skin exposed to sunlight. Be sure to wear sunblock and protective clothing when spending time in the sun.
    Some drugs that cause photosensitivity include amitriptyline (Elavil), Ciprofloxacin (Cipro), norfloxacin (Noroxin), lomefloxacin (Maxaquin), ofloxacin (Floxin), levofloxacin (Levaquin), sparfloxacin (Zagam), gatifloxacin (Tequin), moxifloxacin (Avelox), trimethoprim/sulfamethoxazole (Septra), tetracycline, methoxsalen (8-methoxypsoralen, 8-MOP, Oxsoralen) and Trioxsalen (Trisoralen).
    Medications for HIV/AIDS (Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs)) ...The body breaks down medications used for HIV/AIDS. St. John's wort can increase how quickly the body breaks down these medications. Taking St. John's wort might decrease how well some medications used for HIV/AIDS work.
    Some of these medications used for HIV/AIDS include nevirapine (Viramune), delavirdine (Rescriptor), and efavirenz (Sustiva).
    Medications for HIV/AIDS (Protease Inhibitors) ...The body breaks down medications used for HIV/AIDS to get rid of them. Taking St. John's wort might increase how quickly the body breaks down these medications. This could decrease the effectiveness of some medications used for HIV/AIDS.
    Some of these medications used for HIV/AIDS include amprenavir (Agenerase), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Fortovase, Invirase).
    Medications for migraine headaches (Triptans) ...Some medications for migraine headaches can affect a chemical in the brain called serotonin. St. John's wort can also affect serotonin. Taking St. John's wort along with some medications for migraine headache might cause too much serotonin in the brain and serious side effects including confusion, shivering, stiff muscles, and other side effects.
    Some medications for migraine headache include frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig).
    Medications moved by pumps in cells (P-Glycoprotein Substrates) ...Some medications are moved by pumps in cells. St. John's wort can make these pumps more active and decrease how much of some medications get absorbed by the body. This might decrease the effectiveness of some medications.
    Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.
    Medications for pain (Narcotic drugs) ...The body breaks down some medications for pain to get rid of them. St. John's Wort might decrease how fast the body gets rid of some medications for pain. By decreasing how fast the body gets rid of some medications for pain, St. John's wort might increase the effects and side effects of some medications for pain.
    Some medications for pain include meperidine (Demerol), hydrocodone, morphine, OxyContin and many others.
    Meperidine (Demerol) ...St. John's wort increases a chemical in the brain called serotonin. Meperidine (Demerol) can also increase serotonin in the brain. Taking St. John's wort along with meperidine (Demerol) might cause too much serotonin in the brain and serious side effects including heart problems, shivering, and anxiety.
    Nefazodone (Serzone) ...Nefazodone can increase a chemical in the brain. This chemical is called serotonin. St. John's wort can also increase serotonin. Taking St. John's wort with nefazodone might cause there to be too much serotonin. This could lead to serious side effects including heart problems, shivering, and restlessness.
    Nortriptyline (Pamelor) ...The body breaks down nortriptyline (Pamelor) to get rid of it. St. John's wort can increase how quickly the body breaks down nortriptyline (Pamelor). This could decrease the effectiveness of nortriptyline (Pamelor) works.
    Paroxetine (Paxil) ...Paroxetine (Paxil) increases a chemical in the brain. This chemical is called serotonin. St. John's wort also increases serotonin. Taking paroxetine (Paxil) and St. John's wort together might cause there to be too much serotonin. This could lead to serious side effects including heart problems, shivering, and weakness.
    Pentazocine (Talwin) ...St. John's wort increases a brain chemical called serotonin. Pentazocine (Talwin) also increases serotonin. Taking St. John's wort along with pentazocine (Talwin) might increase serotonin too much. This could cause serious side effects including heart problems, shivering, and anxiety. Do not take St. John's wort if you are taking pentazocine (Talwin).
    Phenobarbital (Luminal) ...The body breaks down phenobarbital (Luminal) to get rid of it. St. John's wort might increase how quickly the body breaks down phenobarbital. This could decrease how well phenobarbital works.
    Phenprocoumon ...The body breaks down phenprocoumon to get rid of it. St. John's wort increases how quickly the body breaks down phenprocoumon. This decreases the effectiveness of phenprocoumon.
    Phenytoin (Dilantin) ...The body breaks down phenytoin (Dilantin) to get rid of it. St. John's wort might increase how quickly the body breaks down phenytoin. Taking St. John's wort and taking phenytoin (Dilantin) might decrease the effectiveness of phenytoin (Dilantin) and increase the possibility of seizures.
    Reserpine ...St. John's wort can decrease the effects of reserpine.
    Sedative medications (Barbiturates) ...Medications that cause sleepiness and drowsiness are called sedatives. St. John's wort might decrease the effectiveness of sedative medications. It is not clear why this interaction occurs.
    Sertraline (Zoloft) ...Sertraline (Zoloft) can increase a chemical in the brain. This chemical is called serotonin. St. John's wort also increases serotonin. This can cause there to be too much serotonin in the brain. This could lead to serious side effects including heart problems, shivering, and irritability.
    Simvastatin (Zocor) ...The body breaks down simvastatin (Zocor) to get rid of it. St. John's wort increases how quickly the body breaks down simvastatin. This can cause simvastatin to be less effective.
    Tacrolimus (Prograf, Protopic) ...The body breaks down tacrolimus (Prograf, Protopic) to get rid of it. St. John's wort can increase how quickly the body breaks down tacrolimus. This can cause tacrolimus to be less effective.
    Theophylline ...The body breaks down theophylline to get rid of it. St. John's wort might increase how quickly the body gets rid of theophylline. Taking St. John's wort along with theophylline might decrease the effectiveness of St. John's wort. But it is not clear if this interaction is a big concern.
    Tramadol (Ultram) ...Tramadol (Ultram) can affect a chemical in the brain called serotonin. St. John's wort can also affect serotonin. Taking St. John's wort along with tramadol (Ultram) might cause too much serotonin in the brain and side effects including confusion, shivering, stiff muscles, and other side effects.
    Warfarin (Coumadin) ...Warfarin (Coumadin) is used to slow blood clotting. The body breaks down warfarin (Coumadin) to get rid of it. St. John's wort might increase the breakdown and decrease the effectiveness of warfarin (Coumadin). Decreasing the effectiveness of warfarin (Coumadin) might increase the risk of clotting. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.
    (KLD)

  9. #9
    Thanks KLD. Wow, Emi, you are lucky not to be on any medications at all! Do you not even take vitamins? PLG

  10. #10
    Originally posted by SCI-Nurse:

    Thanks KLD. Wow, Emi, you are lucky not to be on any medications at all! Do you not even take vitamins? PLG
    Nope, well I should take vitamins but I forget and I use a bisacodyl supp. Thats it!

    "Learn from yesterday, live for today, hope for tomorrow"
    ~ Anon

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