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Thread: More on UCB plus lithium on Yahoo

  1. #1

    More on UCB plus lithium on Yahoo

    My friend is doing a Phd in neurology and her professor had forwarded this to each student. I guess a lot more people will hear about it through this one article.


    http://news.yahoo.com/s/nm/20070308/...ell_trial_dc_1


    Scientists plan China, HK, Taiwan stem cell trial

    By Tan Ee Lyn Thu Mar 8, 3:24 AM ET


    HONG KONG (Reuters) - ''Scientists are preparing for a large clinical trial in 2008 which aims to use stem cells to help 400 patients with spinal cord injuries in Hong Kong, mainland China and Taiwan grow new cells and nerve fibers.

    Stem cells from umbilical cord blood will be injected into the spinal cords of the participants, who will also be given lithium to help stimulate cell regeneration, said Wise Young, a leading neuroscientist and spinal cord injury researcher.

    "What we'd like to do is study a broad range of patients, not just (those with) complete (spinal cord injuries)," said Young, professor at Rutgers' department of cellbiology and neuroscience. Rutgers is the state university in New Jersey in the U.S.

    Researchers are now giving lithium to 20 patients in Hong Kong in the phase 1 safety and feasibility trial. Lithium is a chemical element that is believed to boost cell regeneration.
    In preparation for the large 2008 trial, which will involve 400 patients in 14 mainland Chinese cities, Hong Kong and Taipei, doctors in all three places recently agreed on the method to deliver stem cells into spinal cords, said Young, who is also a visiting professor at the University of Hong Kong.

    Stem cells extracted from matching umbilical cord blood taken from public blood banks will be injected into the spinal cords of the subjects, who will also be given lithium.
    The procedure should hopefully help subjects grow new nerve fibers and "bridges" -- structures that allow the new fibers to reconnect with other parts of the spinal cord.
    "Our main outcome measure will be neurological motor and sensory scores," Young said in an interview with selected media. "We want to see whether the patients recover sensation. It has three measures: touch, pain which is assessed by pin-prick, and the third is strength of 10 standardized muscles."

    STEM CELL GIANT?

    The trial, the biggest in the field in Asia, comes as China is devoting significant resources into stem cell research.

    Its attitude and achievements have drawn U.S.-based scientists like Young to conduct research there due to opposition to embryonic stem cell research in the United States.
    Opponents of embryonic stem cell research, including President George W. Bush, say it is unethical to experiment on human embryos, even those never destined to become a baby.

    Stem cells are the body's master cells, found throughout the tissue and blood. Whether from the adult or from embryos, they may be used to find treatments and cures for serious diseases such as cancer and diabetes.
    Embryonic stem cells are considered potentially the most powerful but are also the most controversial, and federal law greatly restricts the use of taxpayer money to pay for experiments using them.

    "Scientists in the U.S. are so upset at the stopping of (embryonic) stem cell research, but this would be a great opportunity for Asia, great opportunity for China ... because there are so many researchers working in this field," Young said, adding that Hong Kong had a special position in all of this.

    "Hong Kong is in a special position for science because it has credibility. Many people don't trust what is going on inside China," he said, noting also that Hong Kong badly needed government support and funding.

    Private donors are funding the US$26 million spinal cord clinical trial.''

  2. #2

    Dr. Young, this is great! Good Luck!

    Scientists plan China, HK, Taiwan stem cell trial

    08 Mar 2007 07:59:57 GMT
    Source: Reuters
    Alert Me | Printable view | Email this article | RSS [-] Text [+]

    By Tan Ee Lyn

    HONG KONG, March 8 (Reuters) - Scientists are preparing for a large clinical trial in 2008 which aims to use stem cells to help 400 patients with spinal cord injuries in Hong Kong, mainland China and Taiwan grow new cells and nerve fibres.

    Stem cells from umbilical cord blood will be injected into the spinal cords of the participants, who will also be given lithium to help stimulate cell regeneration, said Wise Young, a leading neuroscientist and spinal cord injury researcher.

    "What we'd like to do is study a broad range of patients, not just (those with) complete (spinal cord injuries)," said Young, professor at Rutgers' department of cellbiology and neuroscience. Rutgers is the state university in New Jersey in the U.S.

    Researchers are now giving lithium to 20 patients in Hong Kong in the phase 1 safety and feasibility trial. Lithium is a chemical element that is believed to boost cell regeneration.

    In preparation for the large 2008 trial, which will involve 400 patients in 14 mainland Chinese cities, Hong Kong and Taipei, doctors in all three places recently agreed on the method to deliver stem cells into spinal cords, said Young, who is also a visiting professor at the University of Hong Kong.

    Stem cells extracted from matching umbilical cord blood taken from public blood banks will be injected into the spinal cords of the subjects, who will also be given lithium.

    The procedure should hopefully help subjects grow new nerve fibres and "bridges" -- structures that allow the new fibres to reconnect with other parts of the spinal cord.

    "Our main outcome measure will be neurological motor and sensory scores," Young said in an interview with selected media. "We want to see whether the patients recover sensation. It has three measures: touch, pain which is assessed by pin-prick, and the third is strength of 10 standardised muscles."

    STEM CELL GIANT?

    The trial, the biggest in the field in Asia, comes as China is devoting significant resources into stem cell research.

    Its attitude and achievements have drawn U.S.-based scientists like Young to conduct research there due to opposition to embryonic stem cell research in the United States.

    more:
    http://www.alertnet.org/thenews/newsdesk/HKG344187.htm

  3. #3
    Scientists plan stem cell trial
    Thu Mar 8, 2007 8:03AM GMT

    Email This Article | Print This Article | RSS
    [-] Text [+] By Tan Ee Lyn

    HONG KONG (Reuters) - Scientists are preparing for a large clinical trial in 2008 which aims to use stem cells to help 400 patients with spinal cord injuries in Hong Kong, mainland China and Taiwan grow new cells and nerve fibres.

    Stem cells from umbilical cord blood will be injected into the spinal cords of the participants, who will also be given lithium to help stimulate cell regeneration, said Wise Young, a leading neuroscientist and spinal cord injury researcher.

    more:

    http://uk.reuters.com/article/topNew...34418720070308

  4. #4
    Banned Faye's Avatar
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    Yup Manouli, everywhere Dr Young goes Adult stem cell research (ASCR) starts to flourish. Cord Blood Stem Cells are NOT embryonic stem cells.

    from the yahoo article by cherry

    "Scientists in the U.S. are so upset at the stopping of (embryonic) stem cell research, but this would be a great opportunity for Asia, great opportunity for China ... because there are so many researchers working in this field," Young said, adding that Hong Kong had a special position in all of this.

    ----->Umbiliical cord blood stem cells and litium could have been done right here in the US.

    Also in Dr Young's home state there is ONLY token funding of ESCR, out of a bill specifically drafted to fund ESCR. I don't think Christopher Reeve, Carl Riccio and the kids on crutches expected the bulk of their championed bill to go to adult stem cell research in their own state of NJ.

    http://www.njstemcell.org/news-articles/video-NJ-Governor-Signs-Stem-Cell-Bill.htm video with kids in wheelchairs and crutches, CR and his mother, carl Riccio


    "There’s far too much unthinking respect given to authority,” Molly Ivins explained; “What you need is sustained outrage.”
    Kerr, Keirstead, McDonald, Stice and Jun Yan courageously work on ESCR to Cure SCI.

    Divisiveness comes from not following Christopher Reeve's ESCR lead.
    Young does ASCR.
    [I]I do not tear down CRPA, I ONLY make peopl

  5. #5
    hopefully this study will be the first step in providing a wealth of valuable information.

  6. #6
    thx cherry,
    nice to see the trials hit the mainstream media!

  7. #7
    Senior Member Max's Avatar
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    More news

    Scientists plan China, HK, Taiwan stem cell trial
    08 Mar 2007 07:59:57 GMT
    Source: Reuters

    Alert Me | Printable view | Email this article | RSS [-] Text [+]

    By Tan Ee Lyn
    HONG KONG, March 8 (Reuters) - Scientists are preparing for a large clinical trial in 2008 which aims to use stem cells to help 400 patients with spinal cord injuries in Hong Kong, mainland China and Taiwan grow new cells and nerve fibres.
    Stem cells from umbilical cord blood will be injected into the spinal cords of the participants, who will also be given lithium to help stimulate cell regeneration, said Wise Young, a leading neuroscientist and spinal cord injury researcher.
    "What we'd like to do is study a broad range of patients, not just (those with) complete (spinal cord injuries)," said Young, professor at Rutgers' department of cellbiology and neuroscience. Rutgers is the state university in New Jersey in the U.S.
    Researchers are now giving lithium to 20 patients in Hong Kong in the phase 1 safety and feasibility trial. Lithium is a chemical element that is believed to boost cell regeneration.
    In preparation for the large 2008 trial, which will involve 400 patients in 14 mainland Chinese cities, Hong Kong and Taipei, doctors in all three places recently agreed on the method to deliver stem cells into spinal cords, said Young, who is also a visiting professor at the University of Hong Kong.
    Stem cells extracted from matching umbilical cord blood taken from public blood banks will be injected into the spinal cords of the subjects, who will also be given lithium.
    The procedure should hopefully help subjects grow new nerve fibres and "bridges" -- structures that allow the new fibres to reconnect with other parts of the spinal cord.
    "Our main outcome measure will be neurological motor and sensory scores," Young said in an interview with selected media. "We want to see whether the patients recover sensation. It has three measures: touch, pain which is assessed by pin-prick, and the third is strength of 10 standardised muscles."

    http://www.alertnet.org/thenews/newsdesk/HKG344187.htm

  8. #8
    Faye, I would appreciate it if you would stop calling umbilical cord blood cells "adult stem cells". They are neonatal cells and not all of them are stem cells. We are using mononuclear cells from HLA-matched umbilical cord blood cells.

    Manouli, we just completed a workshop in Kunming (the reason why I was absent from CareCure for 3 days) where over 50 of the top spinal surgeons in China met to discuss the surgical protocol for transplanting cells to the spinal cord. They included some of the most experienced surgoens in the world in transplanting cells into human spinal cord.

    Clinical trials assess safety, feasiblity, risk, and benefit of therapies. We chose umbilical cord blood cells as the first cell transplant therapy to test in the ChinaSCINet because it is safe, feasible, low-risk, and has some potential for benefit. An alternative is bone marrow stem cells but many details of isolating, expanding, and characterizing these cells are still unclear. Immune-compatible embryonic stem cells are not available.

    The trial may show that umbilical cord blood mononuclear cell transplants only have only modest effects on functional recovery. If so, it would be a reasonable control against which to compare other therapies, such as neural progenitor cells derived from fetal or embryonic stem cells. On the other hand, our trial may show that umbilical cord blood cells and lithium together significantly improve neurological function. In either case, we will have significantly advanced the field.

    What we must do, however, is to ensure that the trial is well designed and run so that the results will be credible to clinicians around the world. For example, even though Hungyun Huang has transplanted fetal OEG cells into over 500 patients with spinal cord injury, most doctors don't believe the results. Well-designed and rigorously run clinical trials are necesary.

    Many groups that are applying experimental therapies may not be able to convince the rest of the world. For example, the Beike group in Shenzhen are infusing umbilical cord blood cell intravenously or intrathecally to dozens of patients but, based on what I have heard to date, their results probably will not convince the rest of the world. But, perhaps they are not interested in spreading their therapies.

    We at the ChinaSCINet are committed in proving feasibility, safety, risk, and benefit of the therapies in well-controlled and rigorously run clinical trials so that doctors around the world will adopt the therapies. By doing rigorous, we can ensure rapid acceptance and dissemination of clinical trial results around the world. Every step of the clinical trial process must be carefully designed and executed. This is why I have taken a year off from Rutgers to do.

    I want to point out that the consensus surgical and tranplantation techniques that we have arrived at will be usable for many cell types. Likewise, we have adopted the international system for neurological classification and assessment of spinal cord injury. The government of China recently passed strict standards for clinical trials that require all centers to be GCP-certified. While this has delayed us, it will ensure the highest quality trials.

    Our trial design is drive by the concept that combination therapies will be necessary to achieve the best regeneration. We believe that regeneration needs a cellular bridge (to encourage axonal growth across in the injury site), long-term growth factor support (which we hope to achieve with lithium), and blockade of growth inhibitors (we are awaiting the results of phase 1 trials).

    So, our first trial will be a phase 1 trial to assess oral lithium to establish safety and feasibility. We will then carry out phase 2 trials to assess efficacy of lithium (randomized phase 2 compare as placebo) and umbilical cord blood mononuclear cell transplants. Then, we will do a phase 3 umbilical cord blood transplant that will be randomized to lithium or placebo.

    When the growth inhibitor blockers become available (i.e. Nogo blockers, chondroitinase), we will add them to the trials. Note that we are committed to designing further trials for people who have already participated in earlier trials. These are not one-off trials. This is a new concept in clinical trial design and one that we will have to work hard to establish.

    Wise.

    Quote Originally Posted by Faye
    Yup Manouli, everywhere Dr Young goes Adult stem cell research (ASCR) starts to flourish. Cord Blood Stem Cells are NOT embryonic stem cells.

    from the yahoo article by cherry

    "Scientists in the U.S. are so upset at the stopping of (embryonic) stem cell research, but this would be a great opportunity for Asia, great opportunity for China ... because there are so many researchers working in this field," Young said, adding that Hong Kong had a special position in all of this.

    ----->Umbiliical cord blood stem cells and litium could have been done right here in the US.

    Also in Dr Young's home state there is ONLY token funding of ESCR, out of a bill specifically drafted to fund ESCR. I don't think Christopher Reeve, Carl Riccio and the kids on crutches expected the bulk of their championed bill to go to adult stem cell research in their own state of NJ.

    http://www.njstemcell.org/news-articles/video-NJ-Governor-Signs-Stem-Cell-Bill.htm video with kids in wheelchairs and crutches, CR and his mother, carl Riccio

  9. #9

  10. #10
    Banned Faye's Avatar
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    Quote Originally Posted by Wise Young
    Faye, I would appreciate it if you would stop calling umbilical cord blood cells "adult stem cells". They are neonatal cells and not all of them are stem cells. We are using mononuclear cells from HLA-matched umbilical cord blood cells.
    Dr Young, you can use any cute name you want,.........they are NOT embryonic stem cells.

    Here is what two other neurologists say about Umbilical cord blood stem cells:

    Stice: Stice pointed out that while cord-blood stem cells are probably a better fit for sickle-cell disease, embryonic cells have appeared to be more effective in treating spinal-cord injuries or growing cardiac-muscle cells.

    http://www.jacksonville.com/tu-onlin..._7889575.shtml

    Kerr: And adult stem cells aren't an option. He tried to generate spinal motor neurons from adult stem cells and cells isolated from umbilical cord blood, but decided that programming a blank slate—hESCs—is far more efficient than deprogramming specialized cells and redirecting them toward a different fate. He put everything on hold, pending the outcome of the November midterm elections.

    http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371%2Fjournal.pbio.0050032
    Now I know you are not trying to dedifferentiate the UBC stem cells, you are just trying to have them survive long enough to create a beneficial environment for neuro-regeneration, but just about all ESCR researchers are very skeptical about the Usefulness of adult stem cells including UCB stem cells for neurological conditions, other than for miniscule, and hard to measure improvements that do not significantly increase function in sci.

    To me it's no different than what Lima and Huang did, but this time under the guise of an official scientific trial.

    "There’s far too much unthinking respect given to authority,” Molly Ivins explained; “What you need is sustained outrage.”
    Kerr, Keirstead, McDonald, Stice and Jun Yan courageously work on ESCR to Cure SCI.

    Divisiveness comes from not following Christopher Reeve's ESCR lead.
    Young does ASCR.
    [I]I do not tear down CRPA, I ONLY make peopl

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