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Thread: Top 10 mystery diseases

  1. #11
    Regarding young people who have never smoked dying of lung cancer, I can't help wondering if working in an office with a closed ventilation system and a bunch of laser printers could be a culprit. That and many other environmental agents, like chlorine gas in your shower and radon gas in your basement.

  2. #12
    Quote Originally Posted by antiquity
    Looks like those 'life saving aids therapies' aren't so life saving.

    On the contrary. AZT continues to be life-saving. It reduces the transmission rate from mother to child. If untreated, there is a 25% chance that the child of HIV-infected woman will get the disease. If treated, that chance falls to 2%. There is an increased risk of cancer that is yet undefined because they have not found cancer. They have found evidence of gene damage due to AZT that increases the risk for cancer but the actual risk is not yet known.

    The HIVNET 012 trial in 1997-1999 showed that a single dose of nevirapine given to the mother at the time of labor and to the baby after delivery roughly halved the rate of HIV transmission. It is cheap and easy the administter. The main concern with its widespread use is that this may result in development of drug resistance. While other drugs are available, they must be given for a period of time before labor and after.

    The current regimen that is still recommended for preventing maternal to child transmission is AZT plus 3TC and single dose nevirapine. The AZT is taken after 28 weeks of pregnancy. During labor, she takes AXT and 3TC, as well as a single dose of nevirapine. Her baby then receives nevirapine immediately after birth. The mother continues to take AZT and 3TC for seven days longer, to cut the risk of drug resistance even further (Source).

    So, the question now is whether or not AZT should be removed from the regimen, given the finding of increased gene damage in the baby associated with AZT use. The balancing of risk and benefits is relatively straightforward. A single dose of nevirapine only halves the transmission rate while the AZT plus nevirapine reduces the risk by tenfold. Using nevirapine alone also significantly increases the chances of a nevirapine resistant AIDS virus.

    If I were making the recommendation, AZT plus nevirapine is still better than nevirapine alone, both for the baby, the mother, and society in general.


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