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  • we hear of regranex. although is for foot ulcers. does it work?

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Thread: pressure sore

  1. #1

    pressure sore

    Other than getting a flap. What is the best treatment for a decubitus stage four pressure sore?

  2. #2
    I am moving your post over to the Care forum where it will get a response from the SCi-Nurse and/or Dr. Young. It will be locked here. This forum is for posting and discussion of SCI clinical research studies.


  3. #3
    Join Date
    Mar 2004
    Summerhill, Pa
    My husband had a stage 4 decubitus and went to Pittsburgh,Pa. and was in a research program testing super growth tissue that was grown from male circumsized tissue. They took this tissue and from one donor they could grow enough cells to cover a football field. They implanted this tissue weekly and took measurements of the healing process by pouring a liquid type plastic that formed when poured into the wound. Then they would remove this and weigh it.
    Anyways, this procedure took way over a year. And my husband lost 2 years of work and stayed mostly in bed.
    And then developed a super infection and he was kicked out of the program and had to have the decubitus opened up (which never did close all the way) and start all over again with a flap. The only thing he gained from all of this,is he had a huge open wound that you could see bone and even had to have some of the ischium removed, but because of the experiement he did not have to have muscle transplant.
    Good Luck

  4. #4
    cuky - There are several important factors in the healing of a pressure sore. First and foremost, pressure must be eliminated from the site that is broken down. The existence of pressure prevents a good blood supply to the site. The oxygen, that is carried in the circulating blood, is the basic nutritient to a cell; it is vital in an area where new tissue must be formed that there be a good, continuous flow of blood to the area. Adequate circulation is also a contributor to removing waste products from the damaged tissues.

    Secondly, for a pressure area to heal the bed of the wound must be moist and free of any necrotic tissue, exudate or metabolic waste, residual topical agents or dressing residue. This will mean debriding and/or gentle irrigations with normal saline, [avoid antiseptic agents] to cleanse the wound surface and/or remove the foreign materials noted above.

    Often with a stage IV wound, there is the likelihood of infection in the site or the underlying bone. It would be appropriate to have a consult with an infectious disease doctor to properly assess and manage the condition of the wound. Most often a plastic surgeon and infectious disease specialist work together to manage complicated pressure ulcers.

    A wound of this magnitude would need to have a wet to dry dressing used that is being changed on a regularly prescribed basis. There should be no pockets of air in the dressing as this will interfere with proper healing. There are various products and types of agents that are used. The selection of the correct product will depend on the actual condition and circumstances of the wound.

    In any pressure sore, new tissue must form from the base/bottom of the wound up to the surface for healing to occur. Thei is known as healing by granulation. This tissue is extremely fragile and must be treated with great care. It is also important to keep the skin surrounding the pressure sore dry to avoid further breakdown.

    Lastly, your nutritional intake is extremely important. Your diet should include protein, fruits and vegetables. You should also be taking daily Vitamin C and E, both of which contribute to wound healing and the integrity of the skin.

    To avoid a flap repair, one needs to carefully weigh all of the factors that are involved in getting a stage IV ulcer to heal. It will be a long, involved and tedious process if this is a large ulcer. It will further take a firm commitment on your part and that of your caregiver to be deliberate and consistent in managing this wound.

  5. #5
    Member mjhopper's Avatar
    Join Date
    Aug 2003
    Clearwater, Florida
    Several months ago I had a pressure sore on my foot that would not heal, I did use Regranex which by the way is $500 dollars for a tube and has a short shelf life... fortunate for me my insurance covered most of the cost but it was like pulling teeth. Along with my physican we convinced the insurance company to change their protocal for Regranex. Regranex is normally used for decibutus ulcers caused by Diabetes. Where Regranex helped my dr. decided to try cadaver tissue which helped with closing the wound. Since I now have a powerchair and a different foot plate that's adjustable I no longer have pressure sores. My last chair was a Levo standing wheelchair which had a fixed foot plate.
    By the way while at home I wear men's slippers with memory foam innersole made by Acorn.. They are not a fashion statement but they have been doing their job for a couple of years now.


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