Spinal Cord Injury Research

Shepherd Center supports basic and applied research efforts that are scientifically sound, safeguard the welfare of research participants, and have the potential to advance the field of rehabilitation medicine. Shepherd Center partners with business, industry and institutions of higher education to develop solutions for paralysis, impaired memory, spasticity and a variety of other neurological problems.

Until neural regeneration becomes a reality, Shepherd Center will continue to focus on preserving neurological function through prevention, increasing function through intervention, and setting the standard for independence and quality of life among individuals with spinal cord and brain injuries.

The following is a summary of current initiatives for spinal cord injury research at Shepherd Center.

Prediction of Long-Term Secondary Conditions following SCI(NIDRR; James Krause, PhD) [204]

Electronic Activation Of The Diaphragm For Ventilatory Assist – Device: Neurx RA/4 Ventilatory Assist Device FDA IDE #G920162 – Neurx – RA/4 Percutaneous, Multi Channel, Neuromuscular Stimulator (Brock Bowman, MD, Andrew Zadoff, MD, James Settle, MD, Saeid Khansarinia, MD, Karen Kline, PA, Shepherd Center) IDRR; James Krause, PhD) [382]

A Multi-Center, Double-Blind, Randomized, Placebo-controlled, Parallel-Group Study of the Safety and Efficacy of Repeat Treatment with Two Dose Levels of BOTOX® (Botulinum Toxin Type A) Purified Neurotoxin Complex Followed by a Treatment with BOTOX® in Patients with Urinary Incontinence Due to Neurogenic Detrusor Over-Activity (Jenelle Foote, MD, Continence Clinic Director; Bruce Green, MD, Urology Medical Director; Paul Alphonse, MD, Wylly Killorin, MD; Kevin Rozas, MD; Shepherd Center) [389]

Investigating the Impact of Therapeutic Recreation on the Health Outcomes of Individuals with SCI (Susan Skolnick, Manager, Therapeutic Recreation, Shepherd Center; Dr. Richard Williams, Associate Professor; Janis Florendo, Exercise Specialist, Shepherd Center) [387]

Evaluation Of Effect Of Orthotic Use During Locomotor Training On The Manual Body-Weight Supported Treadmill System (Deborah Backus, PhD, PT, Shepherd Center; Annette Daly, BME, Georgia Institute of Technology) [384]

Post Operative Bracing Of C4-5 And C5-6 Spinal Fractures With Paralysis (David Apple, MD, Shepherd Center) [385]

Evaluation Of Potential Candidates For The Neurorecovery Network Locomotor Training Program: Assessment Of Shepherd Center Inpatients With ASIA C Or D Classification (Deborah Backus, PhD, PT, Leslie VanHeil, BME, MSPT, John Lin, MD, Donald Leslie, MD, Sarah Morrison, PT, Shepherd Center) [386]

Spine Bracing following ORIF for Fracture(Shepherd Center Intramural Fund; David Apple, MD, Shepherd Center) [208]

Lifetime Outcomes and Needs: Refining the Understanding of Aging with Spinal Cord Injury (NIDRR; Daniel P. Lammertse, MD/Susan Charlifue, Craig Hospital & James Krause, PhD) [229]

A 6 Year Longitudinal Study of Community Integration, Subjective Well-Being and Health after SCI: Relationship with Gender, Race/Ethnicity and Environment (NIDRR; James Krause, PhD) [242]

Neuromuscular Electrical Stimulation to reduce Glenohumeral Subluxation after SCI (Shepherd Intramural Fund; David Apple/Joy Bruce/Shari McDowell, Shepherd Center) [246]

Sibling Relationships of Youth with SCI(Zolinda Stoneman, University of Georgia, Tamara King, Shepherd Center) [273]

Real-Time 3D Computer Modeling in SCI Rehabilitation (GIT; Stephen Sprigle, PhD, R. Chitre, PhD, Leslie VanHiel, BME, MSPT, Shepherd Center) [277]

Stability of Vocational Interests Two Years after Spinal Cord Injury: Relationship with employment, participation, and subjective well-being (NIDRR; James Krause, PhD, Medical University of South Carolina, Leslie Hudson, Shepherd Center) [297]

A Phase II Multicenter, Randomized Controlled Study to Evaluate the Safety and Efficacy of Autologous Incubated Macrophages for the Treatment of Patients with Complete Spinal Cord Injuries (Proneuron Biotechnologies; David Apple, MD, Michael Jones, PhD, Shepherd Center) [309]

A Stratified, Randomized, Placebo-Controlled, Single Blind Study of Strength and Endurance Training of the Diaphragm Using the Threshold Inspiratory Muscle Trainer in Acute Spinal Cord Injury (James Settle, MD, Diane M. Johnston, MSPT, Shepherd Center) [317]

Effects of a goal-directed exercise program on functional improvement, self-efficacy, and ASIA scores in spinal cord injured quadriplegics" (Travis Roy Foundation; Susan Sheehy, RN, FAAN, Shepherd Center) [323]

A Phase II, Double-Blind, Placebo Controlled, Multicenter Study to Assess the Efficacy and Safety of HP184 at 100, 200 and 400mg Doses Administered Orally Once Daily for Twenty-Four Weeks in Adult Subjects with Chronic Spinal Cord Injury (CSCI) (AVENTIS; David Apple, MD, Brock Bowman, MD, Shepherd Center) [326]