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Thread: Oxycyte - Blood Substitute (sort of)

  1. #11
    Senior Member lynnifer's Avatar
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    Aug 2002
    Windsor ON Canada
    Wouldn't this help with pressure sores as well?
    Roses are red. Tacos are enjoyable. Don't blame immigrants, because you're unemployable.

    T-11 Flaccid Paraplegic due to TM July 1985 @ age 12

  2. #12
    Senior Member Max's Avatar
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    Jul 2001
    Montreal,Province of Quebec, CANADA

    Artificial blood goes from science fiction to science fact

    Artificial blood goes from science fiction to science fact

    At 20, Bess-Lyn Sannino was a self-described punk rocker with spiky black hair and seven tats from her neck to her left hand. She liked to play rock music on her cello and tended to ride her bike without a helmet. But she was no match for the concrete wall she hit when she lost her brakes going down a steep hill.
    At 22 now, feisty as ever, she's a poster child for a new type of artificial blood that helped her come back from traumatic brain injury.
    ''It works,'' she says. ``I'm totally for it.''
    And she's a powerful inspiration for a 200-patient human trial about to start at the University of Miami School of Medicine into Oxycyte, a Teflon-like liquid that carries four times the oxygen levels of real, red blood cells to brain tissue damaged by traumatic injury. Without that continuous flow of oxygen, brain cells can die within hours.
    If it succeeds in civilian trials here, it could be on the battlefield in Iraq in a year or two to help soldiers who suffer traumatic brain injury from IEDs -- improvised explosive devices. TBI has been called ''the signature wound'' of the Iraq war, with 1,882 cases treated to date. The Department of Defense has signaled its interest in Oxycyte by funding $1.9 million of the $4 million cost of the trials.
    ''If we can interrupt the cascade of cell death during the hours and days after the initial brain injury, we can save someone from a lifetime of disability,'' says Dr. M. Ross Bullock, director of clinical neurotrauma at the University of Miami School of Medicine. He's the lead investigator on the trial, which will take place over the next year at the Miami Project to Cure Paralysis. At the same time, other researchers at the Miami Project will be studying Oxycyte for use in spinal cord injury, says Dr. W. Dalton Dietrich, the project's scientific director.
    ''If we can improve oxygen flow to the compromised area of the spinal cord, and start early enough, some patients can probably benefit,'' he says.
    Other doctors are researching whether Oxycyte can help with stroke, heart attack, cancer, sickle cell anemia, even hard-to-heal diabetic wounds and bed sores. They acknowledge it sounds too good to be true.
    ''If this works, it will be very big,'' says Dr. Harvey Klein, chief of the Department of Transfusion Medicine at the National Institutes of Health, who is not involved in the UM trials. ``But my enthusiasm is tempered by 20 years of experience with these drugs where they haven't worked.
    ``The proof of the pudding will be in the clinical trials.''
    Dietrich expresses hope: ``We do so many complicated things trying to heal injuries. But the simplest way is to improve the flow of blood and oxygen. At the end of the day, if tissue is starved of oxygen, it dies.''
    The trials, starting in June, will involve 200 patients in hospitals in the United States, including UM, Virginia Commonwealth University, the University of Pennsylvania, Fairfax Hospital in Virginia and possibly hospitals in Toronto, Heidelberg, Germany and Bern, Switzerland.
    Two-thirds of the patients, victims of severe brain injury from car accidents, household falls, gunshots and other causes, will be treated with Oxycyte, the rest with inert placebos. Electronic monitors implanted in their brains will gauge the effects. ''We're looking for safety and efficacy -- whether it works,'' Bullock says.

  3. #13
    Senior Member Max's Avatar
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    Jul 2001
    Montreal,Province of Quebec, CANADA

    Published Study Shows Oxycyte Successfully Reduces Oxygen Shortages in a Spinal Cord

    Published Study Shows Oxycyte Successfully Reduces Oxygen Shortages in a Spinal Cord Injury Model

    Last update: 8:50 a.m. EDT July 30, 2008

    COSTA MESA, Calif., Jul 30, 2008 (BUSINESS WIRE) -- Oxygen Biotherapeutics, Inc. (OXBOx

    Sponsored by:

    today announced that a study to be published in the August 2008 edition of the "Journal of Neurosurgery: Spine" demonstrates that Oxycyte(R) can help reduce damage caused by oxygen shortages in a spinal cord injury model. Oxycyte is the Company's perfluorocarbon (PFC) therapeutic oxygen carrier.
    The investigators in the study and authors of the article are Jason L. Schroeder, M.D., Jason M. Highsmith, M.D., Harold F. Young, M.D., and Bruce E. Mathern, M.D. All are with the Department of Neurosurgery, Virginia Commonwealth University Health System in Richmond, Virginia.
    Few therapies have consistently demonstrated effectiveness in preserving oxygen delivery after spinal cord injury (SCI). The researchers measured oxygen levels in rats in two studies to establish a dose response curve. The pressure of oxygen levels dissolved in the blood in spinal cord injury showed a profound drop from 21.4 to 10.4 mm Hg almost immediately post injury. In the relevant experiment, all animals that received Oxycyte combined with 100% oxygen showed significant improvement, with a mean increase in oxygen levels of 23.3 mm Hg. Only one saline-treated animal in the control group showed any benefit. Oxygen values in the group treated with Oxycyte reached up to six times the normal level.
    "The laboratory investigation suggests that administration of a perfluorocarbon with the characteristics and performance of Oxycyte combined with 100% oxygen therapy can reverse tissue oxygen deficit and holds promise for reducing ischemic injury," said Bruce D. Spiess, M.D., Professor Anesthesiology and Emergency Medicine, VCURES/VCU Med Center Richmond, Virginia, and co-chair of the Oxygen Biotherapeutics Medical Advisory Board.
    "Traumatic spine injury is a major cause of long-term disability for our troops in the war zones as well as 200,000 plus civilian injuries per year. If we could develop a rapid technique to salvage as much function as possible immediately after injury, this would be a major breakthrough in spine trauma. The key to tissue salvage may well be immediate oxygen delivery to tissues at risk," said Dr. Spiess.
    "This is exciting news for Oxygen Biotherapeutics, Inc.," said company{86A0BC04-E5D5-484C-A817-83CCC92C1706}&dist=hppr

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