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Thread: Clinical Trials

  1. #221
    Senior Member Duran's Avatar
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    Quote Originally Posted by DarrenCBR View Post
    Thanks for that, will do it now Any info on when they'll be starting trials on chronics????
    According to this article headed "Paralyzed Rats Walk; Humans Next?" from Kristen Philipkoski they should have been in human clinical trials yet (with start date of 2006).

    Smith and his son visited Keirstead and other scientists at the University of California at Irvine in March, and were encouraged to learn that researchers have already begun additional animal studies, and that they anticipate beginning human clinical trials as soon as 2006.
    http://www.wired.com/medtech/genetic.../2005/05/67501

  2. #222
    Senior Member lunasicc42's Avatar
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    well, what happened
    "That's not smog! It's SMUG!! " - randy marsh, southpark

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  3. #223
    Quote Originally Posted by lunasicc42 View Post
    well, what happened
    Not Enough Profit to be made....
    Shame soo many are too Stupid and Greedy to realize what truly matters in life.
    "Only when its too late, do people understand....." (Most anyway.....)
    ====================
    If you stare long enough,
    I may do a Trick....

  4. #224
    Quote Originally Posted by lunasicc42 View Post
    well, what happened
    ..and G.W. was in office...

  5. #225
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    Quote Originally Posted by paolocipolla View Post
    ..and G.W. was in office...
    One have a wiring-diagram, oh a damaged spinal cord, and here one have a remedy to fix that by some nutrition’s by umbilical cord blood. Really?

  6. #226
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    Quote Originally Posted by Duran View Post
    According to this article headed "Paralyzed Rats Walk; Humans Next?" from Kristen Philipkoski they should have been in human clinical trials yet (with start date of 2006).



    http://www.wired.com/medtech/genetic.../2005/05/67501
    Nothing on EU FP7/8?

  7. #227
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    Quote Originally Posted by Chris Chappell View Post
    I would try and contact Tania Cusack, Oz Stewart or Hans Keirstad at the Reeve / Irvine SCI research center in CA for clinical trial info.

    Good luck.
    Don’t drink to much café latte.

  8. #228
    Quote Originally Posted by Leif View Post
    One have a wiring-diagram, oh a damaged spinal cord, and here one have a remedy to fix that by some nutrition’s by umbilical cord blood. Really?
    Leif, Leif, Leif.... What should I do with you?? Keep in mind we are going to meet in few months, so you had better be nice

  9. #229
    Quote Originally Posted by Leif View Post
    One have a wiring-diagram, oh a damaged spinal cord, and here one have a remedy to fix that by some nutrition’s by umbilical cord blood. Really?
    Leif,

    May I ask what brought on this bout of pessimism? The "wiring-diagram" of the spinal cord is actually relatively simple. There are descending fibers and there are ascending fibers. Provided that enough of the fibers get to the right nuclei (in the case of descending fibers, it would the central pattern generator in the L2 spinal cord and, in the case of ascending fibers, it would be nucleus gracilis in the brainstem), you would be able to activate and regulate walking.

    During development, axons grow en masse up and down the spinal cord. Many make connections. As the baby moves and moves, those connections that have activity are enforced while those connections that are not used wane away. By the way, this is what happens after injury... those connections that are not used tend to waste away. That is how the circuitry is remade.

    So, what is wrong with the concept of bridging the injury site with cells (in the specific case that you are talking about, HLA-matched umbilical cord blood mononuclear cells that may stay around long enough to facilitate axonal crossing). If the cells in the bridge produce neurotrophins that are picked up by the axons and that may stimulate the cells to grow more, don't you think?

    The third part of the treatment has yet to come, i.e. blockade of growth inhibitors such as Nogo and CSPG. A number of treatments are under development, including Cethrin, anti-Nogo antibody, anti-Lingo antibody, and chondroitinase. So, when these are available, they will be put on top of the cells and lithium.

    Please, if you have any ideas, it would be good if you would share them. If you think that nothing will work, then please say so, instead of denigrating others.

    Wise.

  10. #230
    Senior Member Rollin Rick's Avatar
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    Quote Originally Posted by Leif View Post
    One have a wiring-diagram, oh a damaged spinal cord, and here one have a remedy to fix that by some nutrition’s by umbilical cord blood. Really?

    Hey Leif, Are you one of those guys who is cranky in the morning, miserable in the afternoon and grouchy at night? LOL

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