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Thread: Clinical Trials

  1. #591
    Quote Originally Posted by CAS View Post
    For anyone interested i found a site that has a list of the human trials on the development of spinal cord research here http://www.stemcellsaustralia.edu.au...rd-Injury.aspx
    Very interesting. Do you know where we can see the outcomes?

  2. #592
    Interesting perspective on the FDA and private stem cell trials and clinics:
    http://www.ipscell.com/2015/01/stemhumanexperiment/

  3. #593
    Last edited by c473s; 03-05-2015 at 10:34 AM.

  4. #594

  5. #595
    Finally its news i ve long been waiting for, stem cell inc have just announced its first study based on improvement and efficacy on its cervical cohorts.
    have no doubt about the professionalism of this trial, two things have really impressed me.
    the swiss gov has made stem cell inc sign a 16 page protocol to protect the patients interests. if you think the FDA are tough on trial ethics and on patient safety so are the Swiss medical authorities.

    Each patient is tested 24/7 for a whole week to assess his/her condition prior implantation in order to compare results after implantation. this after months of assessing reports of your medical history in your own country to vet if you are eligible to be assessed on their own soil.
    Alas a small MRSA infected pressure had excluded me 10 days before implantation when they were doing the T1-to T12 cohort in 2012, they said i would be at risk when immune suppressed for 10 months. This sore had only popped up 7 days i was to board my flight, i already had my tickets in hand however i had no knowledge of the mrsa.
    however the one week experience at Bulgrist university hospital in zurich was such an experience. btw all flights, lodging, meals for me and a person i chose to come with me was paid for by stem cell inc. The study team are amazing people.
    Profs Armin Curt hospital director and head of the study team had told me two interesting things i ve kept in mind since. Once we can overcome the safety barrier we will be able to take bolder steps in dose increase, use of scaffolds and nogo inhibition. i am not technical so the latter i cannot explain to you. Alas again stem cell inc only use official channels to relate their findings so mailing the study team to forward or pass on information is also out of protocol. i really wish this important new phase of the study is a success as it is what we have been waiting for years. After all the hype on the Geron trial on this site which gave up on its first 3 patients stem cell inc are the ones i would keep my eye one. If the efficacy results to be published in the next 6 months are positive and hopefully repeated on multiple cohorts we can proudly say we have a true scientifically proven treatment.

  6. #596
    Senior Member lunasicc42's Avatar
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    Quote Originally Posted by peterf View Post
    Finally its news i ve long been waiting for, stem cell inc have just announced its first study based on improvement and efficacy on its cervical cohorts.
    have no doubt about the professionalism of this trial, two things have really impressed me.
    the swiss gov has made stem cell inc sign a 16 page protocol to protect the patients interests. if you think the FDA are tough on trial ethics and on patient safety so are the Swiss medical authorities.

    Each patient is tested 24/7 for a whole week to assess his/her condition prior implantation in order to compare results after implantation. this after months of assessing reports of your medical history in your own country to vet if you are eligible to be assessed on their own soil.
    Alas a small MRSA infected pressure had excluded me 10 days before implantation when they were doing the T1-to T12 cohort in 2012, they said i would be at risk when immune suppressed for 10 months. This sore had only popped up 7 days i was to board my flight, i already had my tickets in hand however i had no knowledge of the mrsa.
    however the one week experience at Bulgrist university hospital in zurich was such an experience. btw all flights, lodging, meals for me and a person i chose to come with me was paid for by stem cell inc. The study team are amazing people.
    Profs Armin Curt hospital director and head of the study team had told me two interesting things i ve kept in mind since. Once we can overcome the safety barrier we will be able to take bolder steps in dose increase, use of scaffolds and nogo inhibition. i am not technical so the latter i cannot explain to you. Alas again stem cell inc only use official channels to relate their findings so mailing the study team to forward or pass on information is also out of protocol. i really wish this important new phase of the study is a success as it is what we have been waiting for years. After all the hype on the Geron trial on this site which gave up on its first 3 patients stem cell inc are the ones i would keep my eye one. If the efficacy results to be published in the next 6 months are positive and hopefully repeated on multiple cohorts we can proudly say we have a true scientifically proven treatment.

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  7. #597
    Quote Originally Posted by peterf View Post
    Finally its news i ve long been waiting for, stem cell inc have just announced its first study based on improvement and efficacy on its cervical cohorts.
    have no doubt about the professionalism of this trial, two things have really impressed me.
    the swiss gov has made stem cell inc sign a 16 page protocol to protect the patients interests. if you think the FDA are tough on trial ethics and on patient safety so are the Swiss medical authorities.

    Each patient is tested 24/7 for a whole week to assess his/her condition prior implantation in order to compare results after implantation. this after months of assessing reports of your medical history in your own country to vet if you are eligible to be assessed on their own soil.
    Alas a small MRSA infected pressure had excluded me 10 days before implantation when they were doing the T1-to T12 cohort in 2012, they said i would be at risk when immune suppressed for 10 months. This sore had only popped up 7 days i was to board my flight, i already had my tickets in hand however i had no knowledge of the mrsa.
    however the one week experience at Bulgrist university hospital in zurich was such an experience. btw all flights, lodging, meals for me and a person i chose to come with me was paid for by stem cell inc. The study team are amazing people.
    Profs Armin Curt hospital director and head of the study team had told me two interesting things i ve kept in mind since. Once we can overcome the safety barrier we will be able to take bolder steps in dose increase, use of scaffolds and nogo inhibition. i am not technical so the latter i cannot explain to you. Alas again stem cell inc only use official channels to relate their findings so mailing the study team to forward or pass on information is also out of protocol. i really wish this important new phase of the study is a success as it is what we have been waiting for years. After all the hype on the Geron trial on this site which gave up on its first 3 patients stem cell inc are the ones i would keep my eye one. If the efficacy results to be published in the next 6 months are positive and hopefully repeated on multiple cohorts we can proudly say we have a true scientifically proven treatment.
    can you give us a site for watching any news?

  8. #598
    http://investor.stemcellsinc.com/pho...=irol-news&nyo.

    you ca also look up previous posts on this site too.
    Last edited by peterf; 04-19-2015 at 10:43 PM.

  9. #599
    Well Here it is
    its on their news bulletin
    stem cell inc have just began the
    Phase II Study Designed to Assess the Potential of Human Neural Stem Cells to Restore Motor Function.

    Good luck Dr Armin Curt and the study team.


  10. #600

    U.K. Research




    Spinal Research project identifies molecule that could help restore movement and sensation in people paralysed by a spinal cord injury

    Date: March 18, 2016

    Researchers from King?s College London and the University of Oxford have identified a molecular signal, known as ?neuregulin-1?, which drives and enables the spinal cord?s natural capacity for repair after injury.
    The findings, published today in Brain, could one day lead to new treatments which enhance this spontaneous repair mechanism by manipulating the neuregulin-1 signal.
    The research project is funded by leading medical research organisations Spinal Research, Medical Research Council, Wings for Life Spinal Cord Research Foundation, the Wellcome Trust and Henry Smith Charity
    Every year more than 130,000 people suffer traumatic spinal cord injury (usually from a road traffic accident, fall or sporting injury) and related healthcare costs are among the highest of any medical condition ? yet there is still no cure or adequate treatment.
    Spinal cord injury has devastating consequences for muscle and limb function, but the central nervous system does possess some limited capacity to repair itself naturally.
    Understanding what drives this repair mechanism could aid the development of new treatment strategies aimed at boosting the self-healing capacity of the injured spinal cord by taking advantage of ?tools? that the spinal cord already possesses.
    For the first time researchers from King?s and Oxford have identified one of these tools, neuregulin-1, which signals from the surface of damaged nerve fibres during a process called ?spontaneous remyelination.?
    Spontaneous remyelination is a period of natural regeneration that happens in the weeks following a spinal cord injury. The process takes place as a result of damage to spinal nerve fibres which have lost their insulating ?myelin sheath?. This myelin sheath is crucial for efficient communication between the brain and the body.
    However, this natural capacity for repair is not sufficient for full recovery and may account for the compromised function of surviving nerve fibres, which can affect balance, coordination and movement.
    The researchers found that, in mice lacking the neuregulin-1 gene, spontaneous myelin repair was completely prevented and spinal nerve fibres remained demyelinated (i.e. unable to send nerve signals along the spinal cord).
    They also discovered that mice without neuregulin-1 showed worse outcomes after spinal cord injury compared to mice with the gene intact, particularly in walking, balance and coordinated movements.
    Not only did neuregulin- 1 drive spontaneous remyelination, but it also served as a molecular switch for cells within the spinal cord to transform themselves into cells with remyelinating capacity. This is unusual, according to the researchers, because the ?Schwann? cells with new remyelinating capacity normally only myelinate nerve fibres in the peripheral nervous system ? not the central nervous system, as observed here.
    Elizabeth Bradbury, Professor of Regenerative Medicine & Neuroplasticity at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King?s College London, and Medical Research Council Senior Fellow, said: ?Spinal cord injury could happen to anyone, at any time. In an instant your life could change and you could lose all feeling and function below the level of the injury.
    ?Existing treatments are largely ineffective, so there is a pressing need for new regenerative therapies to repair tissue damage and restore function after spinal cord injury.
    ?These new findings advance our understanding of the molecular mechanisms which may orchestrate the body?s remarkable capacity for natural repair.?
    Professor Bradbury added: ?By enhancing this spontaneous response, we may be able to significantly improve spinal cord function after injury. Our research also has wider implications for other disorders of the central nervous system which share this demyelinating pathology, such as multiple sclerosis.?
    Dr Katalin Bartus, also from the IoPPN at King?s College London, said: ?We hope this work will provide a platform for future research, in which it will be important to test how enhancing levels of neuregulin-1 will improve functional outcome after spinal cord injury.?
    This research is collaboration between scientists at King?s ? led by Professor Elizabeth Bradbury ? who work on repairing traumatic injuries of the central nervous sys-tem, and a group of researchers at Oxford ? led by Professor David Bennett ? who work on nerve injury and myelination within the peripheral nervous system. The study was funded by the Medical Research Council, Wings for Life Spinal Cord Research Foundation, the Wellcome Trust and the International Spinal Research Trust and Henry Smith Charity.
    For more infomation contact:
    Alison Wadley
    020 7653 8935


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