Results 1 to 4 of 4

Thread: Neurotrophin-3 enhances neuronal fiber sprouting after spinal cord injury

  1. #1

    Neurotrophin-3 enhances neuronal fiber sprouting after spinal cord injury

    NT-3 delivery through a controlled delivery system based on fibrin scaffolds.

    [*] Taylor SJ, Rosenzweig ES, McDonald JW, 3rd and Sakiyama-Elbert SE (2006). Delivery of neurotrophin-3 from fibrin enhances neuronal fiber sprouting after spinal cord injury. J Control Release Neurotrophins have been shown to promote axonal growth and regeneration after spinal cord injury. The therapeutic utility of neurotrophins may be enhanced by using a controlled delivery system to increase the duration of neurotrophin availability following injury. Such a delivery system can be incorporated into a bioactive scaffold to serve as a physical bridge for regeneration. This study assessed the effect of controlled delivery of neurotrophin-3 (NT-3) from fibrin scaffolds implanted in spinal cord lesions immediately following 2-mm ablation injury in adult rats. Nine days after injury, fibrin scaffolds containing the delivery system and NT-3 (1000 ng/mL) elicited more robust neuronal fiber growth into the lesion than did control scaffolds or saline (1.5- to 3-fold increase). Implantation of fibrin scaffolds resulted in a dramatic reduction of glial scar formation at the white matter border of the lesion. Hindlimb motor function of treated animals did not improve relative to controls at 12 weeks post-injury. Thus, controlled delivery of NT-3 from fibrin scaffolds enhanced the initial regenerative response by increasing neuronal fiber sprouting and cell migration into the lesion, while functional motor recovery was not observed in this model. Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA. http://www.ncbi.nlm.nih.gov/entrez/q..._uids=16797770

  2. #2
    I just wonder why there is no one else interested in this interesting topic...Are there more studies conducted about this?is there any therapy which includes it? It seems to be another promising study which is abandoned....

  3. #3
    Member
    Join Date
    Jul 2004
    Location
    somerset. ca.95684
    Posts
    39
    seems if this is true it might be possible to put remylenating stem cells after words to see if the sprouts can carry a signal doses and duration needed for each would need discovery

  4. #4
    Quote Originally Posted by dan#3 View Post
    seems if this is true it might be possible to put remylenating stem cells after words to see if the sprouts can carry a signal doses and duration needed for each would need discovery
    Shelly Sakiyama-Elbert Professor of Biomedical Engineering on the Joseph and Florence Farrow Endowment & Associate Chair
    http://bme.wustl.edu/people/Pages/fa...spx?faculty=21


Similar Threads

  1. Dr young....
    By Cherry in forum Cure
    Replies: 5
    Last Post: 03-03-2006, 10:51 AM
  2. Replies: 6
    Last Post: 07-23-2005, 06:34 PM
  3. Replies: 3
    Last Post: 03-11-2005, 11:16 PM
  4. Replies: 24
    Last Post: 11-15-2004, 09:50 PM
  5. Replies: 10
    Last Post: 10-14-2004, 08:37 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •