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Thread: If they can do this for mice, they can do it for human

  1. #1

    If they can do this for mice, they can do it for human

    If they can do this for mice, they can do it for human. Wise.

    http://www.wthr.com/Global/story.asp?S=5028395

    Texas Institute for Genomic Medicine Announces First Installation of OmniBank(R) II Mouse Gene Knockout Library

    More Than 90,000 C57BL/6 Knockout Mouse Embryonic Stem Cell Clones Ready for Access By Researchers

    HOUSTON, June 14 /PRNewswire/ -- The Texas Institute for Genomic Medicine announced today that the first installation of the OmniBank II library of knockout mouse embryonic stem cell clones has been completed by Lexicon Genetics Incorporated . The initial installation contains more than 90,000 clones, each representing an embryonic stem cell line in which a single gene has been disrupted, or knocked out. Knockouts of more than 6,000 distinct genes are included in the initial library delivery and will be accessible to researchers worldwide. The library is designed to contain multiple clones for each gene to ensure the successful creation of knockout mice. The cell lines in the library have been generated in the C57BL/6 mouse genetic background and are engineered for the study of gene function, allowing researchers to study the involvement of specific genes in a wide variety of diseases and conditions. This is the largest collection of C57BL/6 mouse gene knockouts in the world.

    When complete in early 2008, the OmniBank II library will house 350,000 mouse embryonic stem cell clones and is expected to cover between 65% and 70% of all mouse genes. The first installation of the library was completed one month ahead of schedule and includes 20% more clones than originally anticipated. The next installation is expected to be completed in December 2006. Through the Institute's agreement with Lexicon, researchers may also access specific cells from Lexicon's existing OmniBank library of 270,000 mouse embryonic stem cell lines in the 129SvEv genetic background.


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  2. #2
    Dr. Young:

    Is it possible for the next step to be human, or will there have to be a couple of more organisms in between, say a cat, dog, chimpanzee, and then a human?

  3. #3
    Quote Originally Posted by Tufelhunden
    Dr. Young:

    Is it possible for the next step to be human, or will there have to be a couple of more organisms in between, say a cat, dog, chimpanzee, and then a human?
    Tufel, I was referring to the fact that they now have a bank of over 200,000 mouse embryonic stem cell lines, containing a wide variety of gene knockouts. These are not just cell lines but cell lines that have been manipulated to have specific gene changes, a procedure that is probably about as difficult to cloning a blastocyst would be.

    If they can be done for mouse embryonic stem cell lines, this can also be done for human embryonic stem cells. This gives you an idea of what could have happened with Clinton's original proposal for NIH to derive human embryonic stem cell lines from in vitro fertilized eggs that are being discarded.

    If Bush had not happened and Gore had become President in 2000, I think that the words in front of the this thread could well be human embryonic stem cell bank, rather than mouse embryonic stem cell bank.

    Wise.

  4. #4
    Dr. Young:

    I should have clarified my question- In the natural progression of research, will the next logical step involve creating similar banks for organisms more complex then mice and eventually reaching the human, or can researchers directly go from creating the bank for mice to creating a similar bank for humans? Which route would be more efficient?

  5. #5
    Quote Originally Posted by Tufelhunden
    Dr. Young:

    I should have clarified my question- In the natural progression of research, will the next logical step involve creating similar banks for organisms more complex then mice and eventually reaching the human, or can researchers directly go from creating the bank for mice to creating a similar bank for humans? Which route would be more efficient?
    Straight to human. Wise.

  6. #6
    Quote Originally Posted by Wise Young
    If Bush had not happened and Gore had become President in 2000, I think that the words in front of the this thread could well be human embryonic stem cell bank, rather than mouse embryonic stem cell bank.

    Wise.
    and if Gore wins in 2008 will he have enough support in Congress to change anything?
    Don't cry because it is over, smile because it happened

  7. #7
    Quote Originally Posted by nicotico
    and if Gore wins in 2008 will he have enough support in Congress to change anything?
    Absolutely. SCREA (the Stem Cell Research Enhancement Act) passed the House of Representative 238-194, despite Bush's veto threat. Over 60 Senators have said that they would vote for SCREA. Even the Majority leader Frist is for SCREA but the Republican party has refused to let the bill onto the floor for a vote. SCREA would not have been necessary and was in fact Clinton's original plan for the NIH. It became necessary after Bush restricted embryonic stem cell research to lines created before 2001. I think that if the President endorsed SCREA, all opposition would melt away.

    It takes time to create a library of stem cells of this size. Even to create a library of 60,000 cell lines would mean making some 200 lines per day in one year. If 10 institutions participated and each contributed 4 lines per day for five years, they could have done it. Kerry and Edwards, if they had won, would have supported such a library but we would not have been able to have it done until 4 years from now.

    Wise.
    Last edited by Wise Young; 06-14-2006 at 04:35 PM.

  8. #8
    Quote Originally Posted by Wise Young
    It takes time to create a library of stem cells of this size. Even to create a library of 60,000 cell lines would mean making some 200 lines per day in one year. If 10 institutions participated and each contributed 4 lines per day for five years, they could have done it. Kerry and Edwards, if they had won, would have supported such a library but we would not have been able to have it done until 4 years from now.

    Wise.
    This is a prefect example of how our small actions or lack of actions today make big consequences in the future.

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