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Thread: List of Drugs in Development for Neurodegenerative Diseases

  1. #1
    Senior Member wang's Avatar
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    List of Drugs in Development for Neurodegenerative Diseases

    Does anyone have a copy of this years list?

    My bet is on Novartis AG to get us out of these chairs. The Novartis trial starts in Q1 2006.

  2. #2
    Thanks for posting - it's an informative list. At least there are a number of entries which list spinal cord injury. Whoe knows what's around the corner

  3. #3

    Non-acutes?

    Are any of the pending trials aimed at chronics does anyone know? Also, what are the combinations

    cheers

  4. #4
    Senior Member roshni's Avatar
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    thinking outside the box

    I guess just scrolling down the "Mode of Action" column gives you a sense of what therapeutic opportunities researchers are thinking about. The question then becomes, what mode of action is being overlooked?

  5. #5
    I could not find a 2005 list of drugs in development for neurodegenerative diseases but here are several other lists of drugs in development:

    "Future Treatments for Depression, Anxiety, Sleep Disorders, Psychosis, and ADHD".
    http://www.neurotransmitter.net/newdrugs.html

    Forbes Magazine: Neurological Drugs to Watch
    http://www.forbes.com/2004/01/26/cx_...tearsheet.html

    DialogSelect lists 5668 titles of Drugs in Development
    http://openaccess.dialog.com/cgi/sea...armDrugDevelop

    Given these lists of drugs in development, it is interesting how few are getting approved by the FDA. http://www.centerwatch.com/patient/d...html#Section10 For example, in 2001-2005, the following are the only drugs approved by the FDA for neurological and related problems. This is it.

    2005
    • Rozerem (ramelteon); For the treatment of sleep-onset insomnia; Takeda; Approved July, 2005
    • TYSABRI (natalizumab); For the treatment of relapsing forms of multiple sclerosis; Elan Pharmaceuticals / Biogen Idec; Approved November 2004 -- UPDATED: SUSPENDED FEBRUARY 2005

    2004
    • Apokyn (apomorphine hydrochloride); For the treatment of acute, intermittent hypomobility episodes associated with advanced Parkinson’s disease; Mylan Bertek Pharmaceuticals; Approved April, 2004
    Lunesta (eszopiclone); For the treatment of insomnia and sleep maintenance; Sepracor; Approved December 2004
    • TYSABRI (natalizumab); For the treatment of relapsing forms of multiple sclerosis; Elan Pharmaceuticals / Biogen Idec; Approved November 2004 -- UPDATED: SUSPENDED FEBRUARY 2005

    2003
    • Cialis (tadalafil); Oral agent for the treatment for erectile dysfunction; Eli Lilly; Approved December 2003
    Levitra (vardenafil); For the treatment of erectile dysfunction related to sexual activity in men; Bayer, GlaxoSmithKline; Approved September 2003
    • Namenda (memantine HCl); For the treatment of moderate to severe dementia of the Alzheimer’s type.; Forest Laboratories; Approved October 2003

    2002
    • Avinza (morphine sulfate); Extended release capsule for the relief of pain requiring continuous, around-the-clock therapy; Elan; Approved March 2002
    Neurontin (gabapentin); Oral treatment for the management of post-herpetic neuralgia (PHN); Pfizer; Approved May 2002
    • Rebif (interferon beta-1a); Subcutaneous injection for the treatment of relapsing forms of multiple sclerosis; Serono Laboratories; Approved March 2002
    • Relpax (eletriptan hydrobromide); For the acute treatment of migraine headaches; Pfizer; Approved December 2002
    Strattera (atomoxetine HCl); For the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in children, adolescents and adults.; Eli Lilly; December 2002
    • Xyrem (sodium oxybate); For the treatment of cataplexy, a sudden loss of muscle tone, associated with narcolepsy; Orphan Medical; Approved July 2002

    2001
    • Axert (almotriptan malate) tablets; For the treatment of migraine attacks; Pharmacia; Approved May 2001
    Bayer Extra Strength Asprin; Oral treatment for mild to moderate migraine pain; Bayer; Approved October 2001
    • Focalin (dexmethylphenidate HCl); For the treatment of attention deficit hyperactivity disorder (ADHD); Celgene; Approved November 2001
    Frova (frovatriptan succinate); Tablets for the acute treatment of migraine attacks; Elan; Approved November 2001
    • Metadate CD; Oral capsules for the treatment of attention deficit hyperactivity disorder; Celltech Pharmaceuticals; Approved April 2001
    Reminyl (galantamine hydrobromide); For the treatment of mild to moderate dementia of the Alzheimer's type; Janssen Pharmaceutica; Approved February 2001
    • Ultracet (acetaminophen and tramadol HCl); For the short-term management of acute pain; Ortho-McNeil Pharmaceutical; Approved August 2001
    • Zomig-ZMT (zolmitriptan); Orally disintegrating tablet for the treatment of acute migraine in adults; AstraZeneca; Approved February 2001

  6. #6
    Wise,
    Milton Friedman pointed out the reason for this bias many years ago. It is because the Food and Drug Administration operates with a skewed risk/reward curve. They simply are not motivated to optimize these approval decisions, as private entities must do. In other words, the Food and Drug Administration is never admonished, or penalized in any way for refusing to allow drugs which are clearly, and ultimately shown to be generally harmless. They are only motivated to keep "bad drugs" out of circulation -- even though these medications are ultimately proven to be harmless.
    What needs to happen is a device to hold the government accountable for this bias, which unfortunately is intrinsic to all governmental entities.
    With respect to the Food and Drug Administration, it can be argued rather persuasively that "health" is worse off in this country due to these structural inconsistencies.
    Don

  7. #7
    Don D,

    In my opinon, the FDA is doing the job that it has been mandated to do, to ensure the safety and efficacy of claims made by companies. The procedures that have been established by FDA have now been adopted more or less world-wide. The FDA is charged with ensuring the safety of drugs and other medical products. They work very hard to make this so. When cases like the Merck Vioxx turned out to have some problems, the FDA is pushed to raise its standards. The American public expects absolute safety and at the same time want to access to risky experimental therapies. The two goals are incompatible. The situation has been complicated recently by the Bush Administration imposing political standards on drug approval. So, the American public has to choose.

    Wise.


    Quote Originally Posted by Don D. 73
    Wise,
    Milton Friedman pointed out the reason for this bias many years ago. It is because the Food and Drug Administration operates with a skewed risk/reward curve. They simply are not motivated to optimize these approval decisions, as private entities must do. In other words, the Food and Drug Administration is never admonished, or penalized in any way for refusing to allow drugs which are clearly, and ultimately shown to be generally harmless. They are only motivated to keep "bad drugs" out of circulation -- even though these medications are ultimately proven to be harmless.
    What needs to happen is a device to hold the government accountable for this bias, which unfortunately is intrinsic to all governmental entities.
    With respect to the Food and Drug Administration, it can be argued rather persuasively that "health" is worse off in this country due to these structural inconsistencies.
    Don

  8. #8
    Senior Member wang's Avatar
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    Here is a list from this year

    I found the list from March 2005

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