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Thread: Nerve guidance channel research will aid nerve repair damage/ Canada

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    Senior Member Max's Avatar
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    Thumbs up Nerve guidance channel research will aid nerve repair damage/ Canada

    Nerve guidance channel research will aid nerve repair damage

    Different combinations of materials will impact different brain neurons to regenerate
    Nov 10/05
    by Elizabeth Raymer (about) (email) Two innovative new studies in nerve guidance channels have significant implications for peripheral nerve repair and spinal cord injury repair strategies.

    In a paper to be published in the January issue of Biomaterials and now available online, researchers describe the development of a new nerve guidance channel design that has shown equivalence to the “gold” standard for peripheral nerve repair. A second paper in the same journal describes how material and growth factor combinations within a nerve guidance channel influence the type of regeneration achieved, which has potential for spinal cord injury repair strategies.
    The first study shows that “the innovation is in the design of the nerve guidance channel,” says Professor Molly S. Shoichet of the Departments of Chemistry, Chemical Engineering and Applied Chemistry, the Institute of Biomaterials and Biomedical Engineering, and the Canada Research Chair in Tissue Engineering.
    The design used coil-reinforced hydrogel tubes that promoted nerve regeneration equivalent to that of nerve autografts; a polymeric coil embedded within the wall structure of the nerve guidance channel created a reinforced polymeric channel that significantly enhances regeneration by ensuring that the tube stays open, allowing severed peripheral nerve ends to regenerate both inside and beyond the tube.
    “What was innovative about this design was that it used a coil-reinforced hydrogel,” a soft material, says Shoichet. “Nerve is a very soft tissue, and we wanted to match the mechanical properties of soft tissue to the channel we’re implanting.” A mismatch can cause cell death. At the same time, “the problem with soft material is that over time it can collapse; that’s what we saw with an earlier study. So we reinforced these tubes with a coil imbedded into the tube wall. We’re still matching the properties of soft tissue, but it won’t collapse because of the coil.”
    Last edited by Max; 11-10-2005 at 03:38 PM. Reason: just because

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