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Thread: Multiple Sclerosis could be linked to viral infection: Scotland

  1. #1

    Multiple Sclerosis could be linked to viral infection: Scotland

    This article published in the journal Multiple Sclerosis presents some information that I was not aware of:
    • Scotland has the highest prevalence of MS in the world.
    • There appears to be a 3-year cycle in the incidence of MS
    • Incidence is 8.2/100,000


    http://www.sundayherald.com/51275
    Multiple Sclerosis could be linked to viral infection

    By Judith Duffy, Health Correspondent

    A NEW study by Scottish researchers shows evidence that the neurological disease multiple sclerosis (MS) could be linked to a viral infection.
    While Scotland has the highest prevalence of MS in the world, the exact factors which lead to its development still remain a mystery. A combination of hereditary and environmental factors are thought to be the likeliest explanation.

    Clusters of MS have previously been noted in certain areas, including the Faroe Islands, Orkney and Shetland.

    Researchers at Dundee University used a comprehensive register which recorded MS cases in Tayside over three decades to examine whether similar outbreaks would appear in a region where there was no prior knowledge of high incidences of the disease.

    The study found peaks of MS occurring in both certain years and in geographical locations, which scientists claim supports the idea that a virus is involved in the development of MS.

    Co-author Dr Peter Donnan, a senior lecturer in medical statistics at the university, said: “We were interested in whether there was any clustering of cases in time and [location] .

    “Nobody really knows what causes MS. It is a multifactorial condition and there are debates about the role of genetic susceptibility and certain childhood viral infection in those who are susceptible, along with unknown environmental factors.

    “In some years there may be epidemics of viral infections and in some years you get less, so what we are looking to see is whether there are peaks in certain years and peaks in certain locations.”

    The study, which is published in this month’s Multiple Sclerosis journal, found there were a total of 772 new cases of the disease.

    Nearly three-quarters of those diagnosed were female and the average age of the onset of symptoms was 35.7 years.

    Researchers found that there was a significant increase in cases between 1982 and 1995, with an annual incident rate of 8.2 per 100,000 population, compared to an overall average figure of 7.2 per 100,000. During the 30 years studied, cases also appeared to peak every two to three years.

    In addition, there was an outbreak of cases during 1993-1995 in a location southwest of Perth, centred in the rural area of Auchterarder but also including part of central Perth.

    During that time, the annual incident rate of cases there rose to 17.1 per 100,000 population.

    Donnan said: “If a viral agent had a role in the development of MS, then you would expect clusters. If you just found that the number of cases was constant over time and areas, then that would tend to go against that hypothesis.

    “What we concluded is that it demonstrated evidence consistent with a role for viral infectious agents in MS.”

    Further investigation, he added, would be needed to help explain why, for example, the incidence of MS appears to peak every three years.

    “One possible explanation is that viral disease epidemics have a three-year cycle,” he said.

    There are an estimated 10,500 people in Scotland with MS, the most common neurological disorder diagnosed among young adults. It attacks the central nervous system and usually strikes between the ages of 20 and 40 years.

  2. #2
    Super Moderator Sue Pendleton's Avatar
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    Wow. I only knew that there was a larger percentage of people with MS among those who lived furthest from the equator. It has been theorized that the cause may be something environmental, specifically food additives, since the more developed countries are those further north and south.
    Courage doesn't always roar. Sometimes courage is the quiet voice at the end of the day saying, "I will try again tomorrow."

    Disclaimer: Answers, suggestions, and/or comments do not constitute medical advice expressed or implied and are based solely on my experiences as a SCI patient. Please consult your attending physician for medical advise and treatment. In the event of a medical emergency please call 911.

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    Super Moderator Sue Pendleton's Avatar
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    Bumped to see if an edit worked.
    Courage doesn't always roar. Sometimes courage is the quiet voice at the end of the day saying, "I will try again tomorrow."

    Disclaimer: Answers, suggestions, and/or comments do not constitute medical advice expressed or implied and are based solely on my experiences as a SCI patient. Please consult your attending physician for medical advise and treatment. In the event of a medical emergency please call 911.

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