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Thread: Nieto, et al. (2005). Titanium mesh stabilization of multilevel laminectomy in rats

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    Nieto, et al. (2005). Titanium mesh implantation-A method to stabilize the spine and protect the spinal cord following a multilevel laminectomy in the adult rat.

    The authors used titanium mesh to stablize and protect rat spinal cord after a multi-level laminectomy, showing that animals that did not have the stabilization became paralyzed.


    Nieto JH, Hoang TX, Warner EA, Franchini BT, Westerlund U and Havton LA (2005). Titanium mesh implantation-A method to stabilize the spine and protect the spinal cord following a multilevel laminectomy in the adult rat. J Neurosci Methods The development of clinically relevant larger spinal cord injury models is in part limited by the possibility of a widened or multilevel laminectomy causing a spinal cord injury from an unstable spine or from compression of the spinal cord by adjacent soft tissues. In the adult rat, we have developed a method to protect the spinal cord and stabilize the spinal column using a titanium mesh implant following a bilateral, multilevel lumbar laminectomy. For this purpose, bilateral and expanded L1-4 laminectomies were performed with or without the use of a titanium mesh to protect the spinal cord and stabilize the spine. Without titanium mesh protection, the rats developed a severe paraparesis or paraplegia, urinary retention, gross anatomical signs of cord compression, and motoneuron loss. In the titanium mesh treatment group, the rats typically maintained a normal gait and lower urinary tract function, normal gross anatomical features of the spinal cord, and normal motoneuron counts. We propose that the use of a titanium mesh implant may assist in the development of clinically relevant larger spinal cord injury and repair models. Department of Neurology and Brain Research Institute, David Geffen School of Medicine at UCLA Los Angeles, CA 90095-1769, USA. http://www.ncbi.nlm.nih.gov/entrez/q..._uids=16024086
    Last edited by Wise Young; 08-03-2005 at 07:19 PM.

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