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    Pain Therapeutics to Present Neuropathic Pain Data at Scientific Meeting

    Interesting new report Source

    SOUTH SAN FRANCISCO, Calif., April 27 /PRNewswire-FirstCall/ -- Pain
    Therapeutics, Inc. (Nasdaq: PTIE), a biopharmaceutical company, today
    announced positive pre-clinical data on a novel treatment for neuropathic
    pain. The Company will present its pre-clinical data at the Scientific
    Meeting of the American and Canadian Pain Societies on Friday, May 7, 2004 in
    Vancouver, Canada.
    The treatment is apparently the combination of "ultra low-dose natrexone plus morphine" to block thermal hyperalgesia and mechanical hypersensitivity (allodynia) in a neuropathic pain model by Todd W. Vanderah, Ph.D., Assistant Professor of Anesthesiology and Pharmacology, University of Arizona and Lindsay H. Burns, Ph.D., Director of Pre-clinical Research at Pain Therapeutics, Inc.

  2. #2
    Senior Member Aquitaine's Avatar
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    That sounds like it might be a good answer for me, my pain seems to be held off now by a combination on neurontin and time release morphine (Oromorph). The down side is the sleepy feeling, some days I just can't wake up, other days I'm just fine.

  3. #3
    Senior Member Max's Avatar
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    Wise,

    I clearly remeber posting this earlier on this forum & I always check my posts to not make doubles...

    There was no your post when I posted mine
    Yet timing appears that you posted earlier,,,,
    Check the responce of same member to both our posts..
    And this thing happened to couple posts before-I thought I'm going crazy
    Could it be some carecure glitch because you moderator & I'm just a member

    http://carecure.org/forum/showthread.php?t=45300

  4. #4
    It's the Matrix....the Oracle told me this would happen

  5. #5
    max, it was my mistake... Your post actually appeared before mine but, for some reason, I did not see yours either. Sorry. Wise.

  6. #6
    Member georgeh's Avatar
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    It sounds like I'm in a similar situation as Aquitane. I take 4800mg of Neurontin and 60mg of MSContin (time release morphine)a day and that combo. seems to keep my pain at a level that allows me to function. Sleepiness is a downside, but the closer I am to being asleep, the lower my pain level is. When I'm asleep, I'm in no pain at all. Maybe this stuff would work for me as well. I don't know what natrexone is. I'll have to look that one up.

  7. #7
    For those of you on morphine doesnt it make you hallucinate? Because when I was in intensive care that morphine had me seeing and thinking crazy stuff.

  8. #8
    Member georgeh's Avatar
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    No, In my case I don't hallucinate at all. The morphine I take is released slowly over a twelve hour period and the dose is pretty small.

  9. #9
    Senior Member Aquitaine's Avatar
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    Hi GeorgeH,

    I'm at 3600mg neurontin, however I've had 41 operations under general anesthesia, and my threshold to opioids is pretty high, so while I started at 60mg a day, within 10 months my body has built up enough resistance to require 180mg a day to have any effect. At this point its leveled off and this dosage (1 60mg tablet 3 times a day) seems to work. Have you had any problems with resistance to the oromorph yet? Probably not as bad as mine, 180mg of even time-release morphine would have most large males asleep all day , I'm pretty sure the sleepiness is caused by the neurontin as when I reduce that it subsides, but the pain comes back , reducing the morphine doesn't help anything.

  10. #10
    Member georgeh's Avatar
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    Hello Aquitaine. I only recently doubled the MS Contin from 30mg/day to 60mg/day. I'm about four years post accident (roof fall- t10 complete para)and my pain didn't develop until about 8-10 months post accident. It's a constant burning pain in both butt cheeks and down the back of my left thigh. When it's really bad, the genital and rectal areas are involved as well; although the pain there is more of a squeezing or pressure type pain. Difficult to describe. I had 2 major DREZ surguries in 2003, each with the hope of eliminating this pain. Unfortunately, neither worked and I've lost about 2-3 inches of sensory level as a result of the surgeries. To answer your question about whether I've built up a tolerance to the MS Contin...to tell you the truth I don't know. I THINK I feel a little better on 60mg/day than I did at 30mg/day but I'm not sure. I really don't think the MSContin reduces the pain at all. It just dulls me down to the point where I can tolerate it. When I'm wide awake, alert, and really living life, the pain is so bad that it makes me want to croak. Living in a fog is no real way to live, but it's the only thing I have right now. I'd like to try doubling the MS Contin again up to 120mg/day to see if I can tell any difference. I'll talk to my pain doc about that. He's not afraid to try anything. He had me all the up to 12,800 mg/day of Neurontin for a little while. It didn't seem to do any more than the 4,800mg/day is doing so we stopped that pretty quick. I also couldn't afford it.

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