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Thread: Diacrin porcine neural stem cell transplant trial for chronic spinal cord injury

  1. #1

    Diacrin porcine neural stem cell transplant trial for chronic spinal cord injury

    Diacrin (http://www.diacrin.com/) has begun a phase 1 trial at Albany Medical Center in Albany and at Washington University in St. Louis (http://www.diacrin.com/newpage1.htm). This trial is currently recruiting patients with chronic spinal cord injury. The contact person at Diacrin regarding this trial is kkerrigan@diacrin.com

    The cells are obtained from fetal pigs that have been genetically modified to reduce the likelihood of immune rejection of cells after transplantation. Due to unknown risks of transmission of pig pathogens to humans, the trial requires participants to agree not to have children. The participant must also agree to be listed by the FDA as a porcine transplant recipient and to allow autopsy if death occurs for any reason.

    Diacrin porcine neural stem cells have been transplanted in over 100 patients in clinical trials of stroke, Parkinson's disease, Huntingtons Chorea, and other neurological disorders. There are concerns that pig cells can carry viruses or other pathogens that can be transformed into human disease. Because the cells come from pigs that are genetically modified to express certain human antigens, participants in the trial will not receive immunosuppression.

    The cells are transplanted to the spinal cord by surgery. Bilby has described his experience as a participant of this trial in the Cure Forum ( "No Change Yet" ).

    [This message was edited by Wise Young on August 06, 2001 at 01:41 PM.]

  2. #2

    Additional links

    The specific web address for a description of the phase 1 6-patient Diacrin porcine stem cell transplant trial can be found at http://www.diacrin.com/newpage1.htm

    A news article describing the Diacrin trial at Albany medical Center can be found at http://www.diacrin.com/SCI%20Albany%20Surg.htm

    Various press articles concerning the Diacrin trials can be found at
    http://www.amc.edu/getnews.cfm?newsid=233
    http://www.wired.com/news/print/0,1294,43340,00.html
    http://home.caregroup.org/newsnow/ar...lpigcells.html
    http://www.sciencedaily.com/releases...0926072621.htm

    The following is a page from Spinal Victory
    http://www.spinalvictory.org/articles/april/page06.htm

    Here are some reports regarding Diacrin's Financial status and plans:
    http://biz.yahoo.com/bw/010724/2680.html

    The site http://thelabrat.com has a summary of Diacrin's trials:
    http://thelabrat.com/jobs/companies/diacrin.shtml

    This is a Parkinson's Report from the Winter of 2000 that describes Genzyme (a partner in the Diacrin effort to develop and test porcine stem cell transplants):
    http://www.parkinson.org/texthtms/tneurocell.htm
    http://www.genzyme.com/neurocell/
    http://www.massbio.org/members/detail.php3?MEMBER_ID=60

    This is a time-line historical listing of events leading to porcine stem cell transplants from a television show called Organ Farm:
    http://tv.carlton.com/organfarm/timeline.jhtml

  3. #3
    Bilby update and discussion
    http://carecure.org/forum/showpost.php?p=64323

    Diacrin Third Quarter Results 2001
    http://carecure.org/forum/showpost.php?p=64323

    Bilby receives porcine stem cell transplant
    http://carecure.org/forum/showpost.php?p=64323

  4. #4
    bump

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