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Thread: Neumann, et al. (2002). Regeneration of Sensory Axons within the Injured Spinal Cord Induced by Intraganglionic cAMP Elevation.

  1. #1

    Neumann, et al. (2002). Regeneration of Sensory Axons within the Injured Spinal Cord Induced by Intraganglionic cAMP Elevation.

    • Neumann S, Bradke F, Tessier-Lavigne M and Basbaum AI (2002). Regeneration of Sensory Axons within the Injured Spinal Cord Induced by Intraganglionic cAMP Elevation. Neuron. 34 (6): 885-93. Summary: The peripheral branch of primary sensory neurons regenerates after injury, but there is no regeneration when their central branch is severed by spinal cord injury. Here we show that microinjection of a membrane-permeable analog of cAMP in lumbar dorsal root ganglia markedly increases the regeneration of injured central sensory branches. The injured axons regrow into the spinal cord lesion, often traversing the injury site. This result mimics the effect of a conditioning peripheral nerve lesion. We also demonstrate that sensory neurons exposed to cAMP in vivo, when subsequently cultured in vitro, show enhanced growth of neurites and an ability to overcome inhibition by CNS myelin. Thus, stimulating cAMP signaling increases the intrinsic growth capacity of injured sensory axons. This approach may be useful in promoting regeneration after spinal cord injury. Departments of Anatomy and Physiology and W.M. Keck Foundation Center for Integrative, Neuroscience, 94143, San Francisco, CA, USA.

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    Human application is possibly when, estimated?

    Onward and Upward!

  3. #3
    I think that clinical trials with rolipram is being considered right now. This is a phosphodiesterase-4 inhibitor which elevates the amount of cAMP in the tissue. Marie Filbin had proposed this and many drug companies are now scrambling to find a PDE4 inhibitor. It is hard to predict a human clinical trial but there is already an MS trial using rolipram.

    [This message was edited by Wise Young on Jul 19, 2002 at 04:44 AM.]

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