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Thread: Intravesical gentamicin is a winner

  1. #1
    Senior Member Jeff's Avatar
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    Post Intravesical gentamicin is a winner

    Just to re-introduce myself... I'm a C6 since 1980. I've been plagued with UTI culminating in kidney infection ever since. Over nearly four decades I have tried literally everything I could find to beat this problem. Thanks to a member here, supporting his father, I decided to try intravesical gentamicin (iGM). I wear a condom style catheter so it's not a natural fit for me. But when you've run out of options you make things work.

    I looked up the protocol with a simple google search, printed out the studies and convinced my doctor. It was the easiest thing I've ever done.

    Six vials (4ml each) containing 80mg of gentamicin diluted in one liter of normal saline solution. You end up with a solution of 480mg gentamicin per 1.024 liter of saline. First, you empty your bladder. Then, using a syringe without a needle, you inject 30ml to 60ml of the solution through the catheter into the bladder. The gentamicin is later passed from your bladder with your urine however you normally do that.

    I started doing the procedure with 30ml every other day due to my doctor being wary. I didn't like it because I would still sometimes see pus or sediment. So, I started doing 30 ml everyday. That was better but kind of a hassle and still occasionally would see pus or sediment. So, I've settled on 60ml every other day. It's more convenient and I never observe pus or sediment.

    Do a google search and read everything. They tried this procedure with colistin and neomycin and various combinations but all those efforts resulted in significant microbial resistance and ultimately failure. Something about gentamicin at a higher concentration renders microbes unable to resist it. The higher concentration also makes gentamicin effective against all kinds of strains that systemic administration won't touch, including gram positive ones. If you're carrying a gentamicin-resistant bug that means an intravenous dose will not help. However, iGM will likely still do the trick.

    It's been over six months and life is a dream. My urine is always crystal clear. There is nothing like iGM for prevention. I only wish I had tried it a long time ago.
    ~See you at the CareCure-used-to-be-paralyzed Reunion ~

  2. #2
    AGREED. it has been shown to drastically reduce resistance. manyyyyyyyyyyy sci's do it and have been for many years. no side effects like orals either.
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  3. #3
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    so, are you saying that gentamicin can be used to treat as well as prevent?
    "courage is fear that has said its prayers"

  4. #4
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    Quote Originally Posted by Jeff View Post
    Just to re-introduce myself... I'm a C6 since 1980. I've been plagued with UTI culminating in kidney infection ever since. Over nearly four decades I have tried literally everything I could find to beat this problem. Thanks to a member here, supporting his father, I decided to try intravesical gentamicin (iGM). I wear a condom style catheter so it's not a natural fit for me. But when you've run out of options you make things work.

    I looked up the protocol with a simple google search, printed out the studies and convinced my doctor. It was the easiest thing I've ever done.

    Six vials (4ml each) containing 80mg of gentamicin diluted in one liter of normal saline solution. You end up with a solution of 480mg gentamicin per 1.024 liter of saline. First, you empty your bladder. Then, using a syringe without a needle, you inject 30ml to 60ml of the solution through the catheter into the bladder. The gentamicin is later passed from your bladder with your urine however you normally do that.

    I started doing the procedure with 30ml every other day due to my doctor being wary. I didn't like it because I would still sometimes see pus or sediment. So, I started doing 30 ml everyday. That was better but kind of a hassle and still occasionally would see pus or sediment. So, I've settled on 60ml every other day. It's more convenient and I never observe pus or sediment.

    Do a google search and read everything. They tried this procedure with colistin and neomycin and various combinations but all those efforts resulted in significant microbial resistance and ultimately failure. Something about gentamicin at a higher concentration renders microbes unable to resist it. The higher concentration also makes gentamicin effective against all kinds of strains that systemic administration won't touch, including gram positive ones. If you're carrying a gentamicin-resistant bug that means an intravenous dose will not help. However, iGM will likely still do the trick.

    It's been over six months and life is a dream. My urine is always crystal clear. There is nothing like iGM for prevention. I only wish I had tried it a long time ago.


    so, are you saying that gentamicin can be used to treat as well as prevent?

    Edit / Delete
    "courage is fear that has said its prayers"

  5. #5
    Senior Member ChesBay's Avatar
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    Quote Originally Posted by jennypenny View Post
    so, are you saying that gentamicin can be used to treat as well as prevent?

    Edit / Delete
    I have been using as a prophylactic / to prevent for about 10 years. It put an end to recurring UTI's which started becoming a major problem at about 27 years post-injury.

    I have gotten one UTI in the last 3 years and I would say it's from me getting lazy on cathing because gentamycin was working so well i had unintentionally cut down on the frequency of cathing. When I got a UTI urologist treated with an oral antibiotic.

    For me, it has been an effective prophylactic rather than a treatment for UTI.

    "New Mobility" article on irrigating / installation:
    http://www.newmobility.com/2015/12/b...ant-solutions/

  6. #6
    What kind of medical insurance coverage do you have and how much is it running cost wise on the schedule you describe (60 mil every other day)?

  7. #7
    Quote Originally Posted by crags View Post
    What kind of medical insurance coverage do you have and how much is it running cost wise on the schedule you describe (60 mil every other day)?
    And what kind of pharmacy fills the prescription? I live in northern California outside of San Francisco, and local retail pharmacies won't touch the prescription. Do you go to a compounding pharmacy? or mail order pharmacy?

    My urologist says he has prescribed it a few times, but getting the medication always ends up to be a major hassle for him, his staff, and the patient.

  8. #8
    my ins covers gent no problem, i get the 2ml/80mg vials and mix in saline. i get the saline from my urological supplier.....

    i had it filled at my target/cvs for a long time then there was a shortage so i started getting it filled at a hospital pharmacy. in network it was $38 per 90 day supply out of network at hospital pharmacy $140 for 90 days
    its meant to be used as a preventive not treatment
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  9. #9
    Senior Member Oddity's Avatar
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    I get it from Walgreens and CVS no problem, just don't expect them to compound it for you. I get gent for about $10 a month, plus saline and 60cc syringes, it's maybe $15. Compounding pharmacy wanted over $200 for the same prescription pre-compounded. Mixing the liquids is so easy it's just not worth it to go to a compounding pharmacy. Just get the components separate.


    Quote Originally Posted by gjnl View Post
    And what kind of pharmacy fills the prescription? I live in northern California outside of San Francisco, and local retail pharmacies won't touch the prescription. Do you go to a compounding pharmacy? or mail order pharmacy?

    My urologist says he has prescribed it a few times, but getting the medication always ends up to be a major hassle for him, his staff, and the patient.
    "I have great faith in fools; self-confidence my friends call it." - Edgar Allen Poe

    "If you only know your side of an issue, you know nothing." -John Stuart Mill, On Liberty

    "Even what those with the greatest reputation for knowing it all claim to understand and defend are but opinions..." -Heraclitus, Fragments

  10. #10
    Quote Originally Posted by Oddity View Post
    I get it from Walgreens and CVS no problem, just don't expect them to compound it for you. I get gent for about $10 a month, plus saline and 60cc syringes, it's maybe $15. Compounding pharmacy wanted over $200 for the same prescription pre-compounded. Mixing the liquids is so easy it's just not worth it to go to a compounding pharmacy. Just get the components separate.
    totally agree
    here is the way mine comes, vials have at least a year shelf life
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