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  1. #1
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    Jerry Silver update


  2. #2
    Yea. Heading in the right direction. Thank you Dr. Silver and his team!!

  3. #3
    Quote Originally Posted by 6 Shooter View Post
    Yea. Heading in the right direction. Thank you Dr. Silver and his team!!
    If you have any questions about our new work then please just ask and I will do my best to answer.

    Here is a link to the paper for all to read. it is open access. "Rapid and robust restoration of breathing long after spinal cord injury"

    https://www.nature.com/articles/s41467-018-06937-0

  4. #4
    Quote Originally Posted by jsilver View Post
    If you have any questions about our new work then please just ask and I will do my best to answer.

    Here is a link to the paper for all to read. it is open access. "Rapid and robust restoration of breathing long after spinal cord injury"

    https://www.nature.com/articles/s41467-018-06937-0

    Keep up with this fantastic work, Jerry.
    No one ever became unsuccessful by helping others out

  5. #5
    Quote Originally Posted by jsilver View Post
    If you have any questions about our new work then please just ask and I will do my best to answer.

    Here is a link to the paper for all to read. it is open access. "Rapid and robust restoration of breathing long after spinal cord injury"

    https://www.nature.com/articles/s41467-018-06937-0
    Is there anything that we can do to help with the process moving forward?

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    Yes Dr. Silver

    Human trials??? Especially hand function.

  7. #7
    Dr. Silver, in the paper it states that the study was not “optimised for effects upon the forelimb” in your rodents. Will your very next study be? If not, will it be a central focus in the near future? And a deep thank you for committing your life to this work.

  8. #8
    Quote Originally Posted by UpAndAdam View Post
    Dr. Silver, in the paper it states that the study was not ?optimised for effects upon the forelimb? in your rodents. Will your very next study be? If not, will it be a central focus in the near future? And a deep thank you for committing your life to this work.

    Thanks for the question. In our initial study we were attempting to target only the motor neurons that project out to the diaphragm. They are called "phrenic" motor neurons and they form a cigar shaped collection of cells that lie between cervical level 3 (C3) thru cervical level 6 (C6). So we focused our one-time, single microinjection of the enzyme only at C4. However, there are also motor neuron pools at C5 that project out to some of the muscles of the upper arm. Thus, likely because of diffusion of the enzyme a bit more "south" to levels C5-6, return of upper arm function occurred but was not targeted by design. It was just a nice and unexpected side effect. The major motor neuron pools for hand function are down a bit lower around C6-8. So, we are now repeating our experiments but focusing on levels C5-8.

  9. #9
    Senior Member lunasicc42's Avatar
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    the golden question is: "approxamitely how long until human trials commence"

    EDIT: big congratulations and appreciation for you and your teams work
    "That's not smog! It's SMUG!! " - randy marsh, southpark

    "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


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  10. #10
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    Jerry will your therapy cure bladder bowel sexual function in chronic lumbar injury patients too? When starting trial and will you take lumbar injury patients in trials?

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