Reality about cure of SCI

[lynnifer]

And here come a whole lot more worldwide:

https://www.cdc.gov/acute-flaccid-my...veillance.html

Resembles what I had at 12.

[niallel]

Whereas, this Renetx stuff is a pharmalogical blockade with antibodies against the Nogo receptor. It would make sense to combine Chondroitinase with a NoGo Trap therapeutic. Basically it's signalling protein on neuron receptors.

(KO of the PTEN gene required no Chondroitinase to quickly grow rivers of axons over CSPG). Axons on steroids....

Thanks Grammy, that really helps with understanding the differences. I'd tried to read the PTEN gene study, but it was far too complicated for me to even understand the odd sentance.

[darty]

Maybe.

Throughout the body, nerves repair just fine. It's only in the spinal cord and brain that they do not repair themselves. In rats, a recent study deleted a single dna sequence and nerve regrowth was restored in those rats' spinal cords.

If there's going to be a near-term "cure" for SCI it's going to be something like this. Even then, once new nerves grow and reconnect you're essentially a funking 9 month old baby learning to move its limbs again...LOTS of PT if you're ever going to relearn those connections from scratch.

I used to send articles to my Dr. about Rats being cured. His answer was "too bad your not a lab rat".

[Rick1]

Maybe.

Throughout the body, nerves repair just fine. It's only in the spinal cord and brain that they do not repair themselves. In rats, a recent study deleted a single dna sequence and nerve regrowth was restored in those rats' spinal cords.

If there's going to be a near-term "cure" for SCI it's going to be something like this. Even then, once new nerves grow and reconnect you're essentially a funking 9 month old baby learning to move its limbs again...LOTS of PT if you're ever going to relearn those connections from scratch.

Not necessarily from scratch since a strong synchrony between CNS maturation and structural or anatomical development already exists. Essentially, you are re-training a fully developed CNS (including brain) that already has complex motor patterns ingrained in the system. Effective activation sequencing coupled with a comprehensive training program should significantly bend the learning curve.

[Mize]

I used to send articles to my Dr. about Rats being cured. His answer was "too bad your not a lab rat".

Rats get all the love.

[mississippi]

My son said it the best way I could ever explain it! When God is ready for me to walk I will! Who can argue with that! If you?re a smart person with negative opinions I suggest you keep them to yourself!

[PeteShick]

Wake up people! I'm 40 years post in March '19. It's finally done. Exciting times!
World-wide Approval in 2021. We then will start Phase III trials to provide market approval in the United States, Europe, India, and China. The goal is to obtain world-wide regulatory approval for the first therapy that restores walking in people with chronic spinal cord injury. Not only will this enable insurance coverage, but it is the only way to dispel the pessimism and skepticism that has dominated the field and achieve consensus that there are safe and effective regenerative therapies to restore meaningful function in people with chronic severe spinal cord injury.

[Patrick Madsen]

Those of us who have been hearing the "In five years" BS for close to 50 years don't consider them negative opinions; Just realistic.

[Silvio GS]

My son said it the best way I could ever explain it! When God is ready for me to walk I will! Who can argue with that! If you?re a smart person with negative opinions I suggest you keep them to yourself!

Sorry but I just can’t help myself))
So God doesn’t want your son and everybody else to walk? )

[Mize]

The latest ChABC + oNPCs paper is out and the results, provided the can be repeated and extended to multiple treatments in humans, are huge news for younger SCIs. This was an animal study where a single treatment (2 injections one week apart) measurably and statistically improved function in rats that were 6 weeks post injury. It's a very thorough paper.

Too bad I'm not younger as this could be something in 20 years.