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Thread: Reality about cure of SCI

  1. #11
    Quote Originally Posted by Mize View Post
    In rats, a recent study deleted a single dna sequence and nerve regrowth was restored in those rats' spinal cords.
    Thats interesting, which study was that?

  2. #12
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    Grammy posted it. I think this is the same:

    https://www.sciencedaily.com/releases/2018/06/180614213734.htm
    T3 complete since Sept 2015.

  3. #13
    Quote Originally Posted by Mize View Post
    Grammy posted it. I think this is the same:

    https://www.sciencedaily.com/releases/2018/06/180614213734.htm

    https://academic.oup.com/brain/article/141/8/2362/5036378


    Ah yes, that was probably Emily's DREADD paper! The premise behind the paper was finding an alternate route for administering Chondroitinase for a longer sustained period of time. The effects of direct Chondroitinase injections is short lived because it isn't very heat tolerant and the saturation area of medication is minimal. To increase the efficacy of a treatment they've tried several different methods which includes a heat stabilized formulation introduced by Ravi Bellamconda with a sustained release of a couple weeks. They've also used viral vectors which has shown to be difficult to turn on and off and with this paper, the lab wanted to try using a DREADD. The use of a DREADD is really quite clever and may possibly be the acceptable method to administer in the end. I believe when they first decided to try this in the lab, the first gene treatment had just gotten it's approval in the UK.

  4. #14
    Thanks for that. I thought it was a new one I'd not heard of.

    This one with the lentiviral vector is going to be the fallback plan if they can't get the next stage working, where Joost Verhaagen is working on transferring the gene therapy developed in the lentiviral vector to an Adeno-associated viral (AAV) vector.

  5. #15
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    I was actually thinking of this one from Grammy's site:
    https://spinalcordresearchandadvocac...d-nerve-cells/
    T3 complete since Sept 2015.

  6. #16
    Thats really interesting, I hope they are going to carry on the work.
    I imagine it would still need Chondroitinase/CSPG/etc to allow the axons to grow past the scar. But you're right this is another piece that disproves the original topic.

  7. #17
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    Quote Originally Posted by BSgimp View Post
    To Whom It May Concern,

    we are decades away from anything close to an effective therapy that promotes neurological recovery of chronic spinal cord injury.

    If you visit this forum frequently hoping one day you will find a miracle cure. Stop wasting your time.
    If you are considering going to some unregulated stem cell therapy clinic. Stop, you are wasting your money/time and taking a risk for nothing.
    If you are here cause you saw some sensationalized article title claiming mouse with SCI is running a marathon. Stop and click away. You have been fooled and you are wasting your time.
    If you consider any invasive procedure to use some untested on humans device to stand for a couple minutes. Stop, and think about the risks you are taking. And the benefit you might/might not get.

    The best thing we can do at this point is to move on with our lives. Be the most productive we can be. And support researchers we believe can have the biggest impact in the future. Our best hope is in a combination of everything that in on the horizon. The horizon that is far more distant than we realize.
    It's like living your life waiting to win the lottery... if you're doing that you're stupid because the odds are not in your favor... spend your time LIVING your life as best you can... and if you luck out and win the lottery all the better... but don't count on it.

  8. #18
    Quote Originally Posted by niallel View Post
    Thats really interesting, I hope they are going to carry on the work.
    I imagine it would still need Chondroitinase/CSPG/etc to allow the axons to grow past the scar.
    Not really. The PTEN gene work disproves that assumption.

  9. #19
    Quote Originally Posted by GRAMMY View Post
    Not really. The PTEN gene work disproves that assumption.
    Thats interesting. I was thinking that because I was told when the Renetx stuff was tested with chase it worked much better.

  10. #20
    Quote Originally Posted by Mize View Post
    I was actually thinking of this one from Grammy's site:
    https://spinalcordresearchandadvocac...d-nerve-cells/

    https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30403-0
    Yes, that is the paper on gene sorting which was the premise of the gene screening for neural axon regeneration (Strittmatter) that I thought we were referring to. Hundreds of genes have been implicated in axon regeneration and should be properly screened for their therapeutic potential. Several really good labs are working hard in this research area. Many of them are cited in the paper.


    Quote Originally Posted by niallel View Post
    Thats interesting. I was thinking that because I was told when the Renetx stuff was tested with chase it worked much better.
    https://www.renetx.com/publications.html

    Whereas, this Renetx stuff is a pharmalogical blockade with antibodies against the Nogo receptor. It would make sense to combine Chondroitinase with a NoGo Trap therapeutic. Basically it's signalling protein on neuron receptors.

    (KO of the PTEN gene required no Chondroitinase to quickly grow rivers of axons over CSPG). Axons on steroids....
    Last edited by GRAMMY; 10-24-2018 at 01:39 AM.

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