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Thread: Discovery offers new hope to repair spinal cord injuries

  1. #11
    Quote Originally Posted by lunasicc42 View Post
    But I thought a rat takes a lot less time injured to be considered a chronic injury... I forget: what time frame constitutes as a chronic injury in a rat... The answers I hear always differ a little and I am not sure

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087825/
    This may help. Here's a recent paper by Lars Olson. He's one of the best scientist working in the field.

    Mice are generally used in working with gene therapies and proteins. The rat model more closely resembles the human injury and is much easier to work with in a lot of ways, especially during surgery. In rats, reactive astrocytes cluster at the border of the lesion by 1-2 weeks after injury; after 2-3 weeks, the astrocytic ?scar? has matured. Genetic modification is more difficult in the rat than in the mouse and, even though new methods have recently resulted in some commercially available genetically modified rats, mice remain the animal of choice for studies involving genetic manipulation. Although rats are larger than mice, the rat is still a very small animal compared to humans. Hence, long-distance axon regeneration, as needed in humans to repair spinal injuries, cannot be directly studied in the rat. Indeed, experimental results from rodent studies that report improved axonal growth (e.g. because of axons bridging the lesion site) might misinform us, because the volumes of gray matter that need reinnervation are much larger in humans than in rats. Human recovery after spinal cord injury is also slower than in the rat. Spontaneous recovery in humans is not considered to reach a plateau until 6-12 months after injury. The recovery of rats, on the other hand, typically plateaus ∼6-8 weeks after injury. The different time scales might reflect the longer regeneration distances needed in humans, compared to rats. As much as the short recovery period in rats is an advantage with respect to advancing experimental research, this difference in recovery periods might have implications for the investigation of therapies, particularly for treatments that need to be implemented during a specific time window. Data concerning secondary injury in humans also point to an extended timeframe in comparison to rats.

  2. #12
    Senior Member lunasicc42's Avatar
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    is there a good reason that some researchers do their studies on rats and others do studies on mice... Whats superior in relation to spinal cord injury studies... I guess ideally they would all be able to use primates
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  3. #13
    Scientific articles:
    http://www.nature.com/sc/journal/v52...tcallback=true
    "Rats are used most commonly in preliminary studies as they are relatively inexpensive, readily available and have demonstrated similar functional, electrophysiological, and morphological outcomes to humans following SCI"

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283285/
    See Table 1

    Corporate ad:
    http://www.transposagenbio.com/blog/rats-vs.-mice-in-genetic-rodent-model-engineering/
    Copy/Paste link to view

    And the opposition:
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545171/

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