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Thread: From transplanting Schwann cells in experimental rat SCI to human SCI

  1. #1

    From transplanting Schwann cells in experimental rat SCI to human SCI

    Prog Brain Res. 2017;231:107-133. doi: 10.1016/bs.pbr.2016.12.012. Epub 2017 Mar 31.

    From transplanting Schwann cells in experimental rat spinal cord injury to their transplantation into human injured spinal cord in clinical trials.

    Bunge MB1, Monje PV2, Khan A3, Wood PM2.
    Author information

    Among the potential therapies designed to repair the injured spinal cord is cell transplantation, notably the use of autologous adult human Schwann cells (SCs). Here, we detail some of the critical research accomplished over the last four decades to establish a foundation that enables these cells to be tested in clinical trials. New culture systems allowed novel information to be gained about SCs, including discovering ways to stimulate their proliferation to acquire adequately large numbers for transplantation into the injured human spinal cord. Transplantation of rat SCs into rat models of spinal cord injury has demonstrated that SCs promote repair of injured spinal cord. Additional work required to gain approval from the Food and Drug Administration for the first SC trial in the Miami Project is disclosed. This trial and a second one now underway are described.
    ? 2017 Elsevier B.V. All rights reserved.

    Human Schwann cells; Schwann cell clinical trials; Schwann cell transplantation; Spinal cord injury; Spinal cord repair
    “As the cast of villains in SCI is vast and collaborative, so too must be the chorus of hero's that rise to meet them” Ramer et al 2005

  2. #2
    Senior Member lynnifer's Avatar
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    Windsor ON Canada
    FOUR DECADES!!!!!!! By all means Miami Project, take your sweet arse time!
    Roses are red. Tacos are enjoyable. Don't blame immigrants, because you're unemployable.

    T-11 Flaccid Paraplegic due to TM July 1985 @ age 12

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