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Thread: New Clinical Trials?

  1. #1
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    New Clinical Trials?

    Hi there!

    I'm new here and I was wondering if there are any upcoming clinical trials. I'd like to get on the list for those!

    Thanks,
    Jennifer

  2. #2

  3. #3
    Quote Originally Posted by Jennifer1 View Post
    Hi there!

    I'm new here and I was wondering if there are any upcoming clinical trials. I'd like to get on the list for those!

    Thanks,
    Jennifer
    https://www.u2fp.org/educate/clinical-trials/

  4. #4
    Quote Originally Posted by GRAMMY View Post

    Spinal cord injury: Using cortical targets to improve motor function

    Date:June 22, 2017Source:University of Miami Miller School of MedicineSummary:New research provides the first evidence that cortical targets could represent a novel therapeutic site for improving motor function in humans paralyzed by spinal cord injury. Share:

    FULL STORY

    Monica A. Perez, P.T., Ph.D., Associate Professor, Department of Neurological Surgery and The Miami Project, and colleagues, recently published A novel cortical target to enhance hand motor output in humans with spinal cord injury in the June issue of Brain that provides the first evidence that cortical targets could represent a novel therapeutic site for improving motor function in humans paralyzed by spinal cord injury (SCI).


    A main goal of rehabilitation strategies in humans with SCI is to strengthen transmission in spared neural networks. Although neuromodulatory strategies have targeted different sites within the central nervous system to restore motor function following SCI, the role of cortical targets remains poorly understood.
    "I am excited to see that electrophysiology can be successfully used to guide interventions for recovery of function after spinal cord injury," says Dr. Perez.
    In this study, Drs. Perez, Jinyi Long, Ph.D., and Paolo Federico, Ph.D. used 180 pairs of noninvasive transcranial magnetic stimulation for 30 minutes over the hand representation of the primary motor cortex at an interstimulus interval mimicking the rhythmicity of descending late indirect (I) waves in corticospinal neurons (4.3 ms; late I-wave protocol) or at an interstimulus interval in-between I-waves (3.5 ms; control protocol) on separate days in a randomized order.
    Late I-waves are thought to arise from trans-synaptic cortical inputs and have a crucial role in the recruitment of spinal motor neurons following SCI. The researchers found that the excitability of corticospinal projections to intrinsic finger muscles increased in SCI and uninjured participants after the late I-wave but not the control protocol for 30 to 60 minutes after the stimulation. Importantly, individuals with SCI were able to exert more force and electromyographic activity with finger muscles after the stimulation showing an enhanced ability to grasp small objects with their hands.


    "This study is a major contribution to the realization of a powerful new class of rehabilitation therapies that can target beneficial plasticity to crucial sites in the nervous system. By taking advantage of recent scientific and technical advances, Dr. Perez's group produced beneficial change in the cortical circuitry and spinal connections underlying voluntary movement," says Dr. Jonathan R. Wolpaw, M.D. Director of the National Center for Adaptive Neurotechnologies Albany, New York.
    "This carefully conducted study provides several pieces of important information in developing strategies to improve function following spinal cord injury. They provide further evidence demonstrating rather clearly, contrary to years of dogma, that positive functional plasticity potential persists within the sensorimotor system for years after a spinal injury," says Dr. Reggie Edgerton, Ph.D. UCLA Brain Research Institute.
    These results emphasize the need to develop new rehabilitation therapies based on mechanistic approaches to improve motor function in humans with paralysis due to spinal cord injury. Currently, Dr. Perez' group is testing the effect of this intervention when given on consecutive days and in individuals with more severe muscle paralysis.
    "What I find appealing about the work is that they exploit a basic characteristic of the human corticospinal neural circuit and designed a way to strengthen connections that does not depend on the person performing a motor task," said John H. Martin, Ph.D., The City College of New York

  5. #5
    Senior Member trekker6's Avatar
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    I've been participating in these studies with TMS (transcranial magnetic stimulation), electrostimulation and hypoxia, Dr. Perez came down yesterday to help with some problems we were having, they want to start a new study. The improvements are temporary, but possibly long term stimulation may induce some permanent improvements.
    "Would you rather reduce deficits and interest rates by raising revenue from those who are not now paying their fair share, or would you rather accept larger budget deficits, higher interest rates, and higher unemployment? And I think I know your answer." Ronald Reagan"

  6. #6
    Quote Originally Posted by Sparky831 View Post
    This website here is a JOKE. I've emailed all of them multiple occasions and have never been responded too ! Don't waste your time

  7. #7
    Quote Originally Posted by Ajstevens View Post
    This website here is a JOKE. I've emailed all of them multiple occasions and have never been responded too ! Don't waste your time
    What were you expecting from this site? It is merely a clearing house/listing of clinical trials taking place in the USA and internationally. It is housed in the National Institutes of Health. They don't run most of the studies, nor do they endorse or vet them (it says this clearly on the web page). The database currently lists 247,869 studies with locations in all 50 States and in 202 countries. The listing has the contact information for the principal investigator of each study. That is who you need to contact if you want to find out more about a study, not the NIH.

    (KLD)

  8. #8
    Sci nurse I have contacted the people that it says too.. No response,, ever

  9. #9
    Senior Member trekker6's Avatar
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    Quote Originally Posted by Ajstevens View Post
    Sci nurse I have contacted the people that it says too.. No response,, ever
    Some of the studies are discontinued, completed or full, the site probably wasn't notified of changes, I've actually contacted some of the sites for studies on small lung cancer and have talked to the researchers. It's a very handy tool.
    "Would you rather reduce deficits and interest rates by raising revenue from those who are not now paying their fair share, or would you rather accept larger budget deficits, higher interest rates, and higher unemployment? And I think I know your answer." Ronald Reagan"

  10. #10
    Quote Originally Posted by Ajstevens View Post
    Sci nurse I have contacted the people that it says too.. No response,, ever
    Then that is the fault of the individual researchers, not of this NIH site.

    (KLD)

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